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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
290 cases with simple somatic mutation data · 619 cases total · 2026-01-07 · mapped to Diffuse Glioma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | PTEN | Ssm | 90 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 290 |
| 31% |
| cbioportal |
| 2 | TP53 | Ssm | 84 | 290 | 29% | cbioportal |
| 3 | EGFR | Ssm | 77 | 290 | 26.6% | cbioportal |
| 4 | TTN | Ssm | 74 | 290 | 25.5% | cbioportal |
| 5 | MUC16 | Ssm | 47 | 290 | 16.2% | cbioportal |
| 6 | PIK3R1 | Ssm | 33 | 290 | 11.4% | cbioportal |
| 7 | FLG | Ssm | 32 | 290 | 11% | cbioportal |
| 9 | PIK3CA | Ssm | 32 | 290 | 11% | cbioportal |
| 8 | NF1 | Ssm | 32 | 290 | 11% | cbioportal |
| 10 | RYR2 | Ssm | 29 | 290 | 10% | cbioportal |
| 11 | PCLO | Ssm | 28 | 290 | 9.7% | cbioportal |
| 12 | SPTA1 | Ssm | 27 | 290 | 9.3% | cbioportal |
| 13 | RB1 | Ssm | 25 | 290 | 8.6% | cbioportal |
| 14 | MUC17 | Ssm | 23 | 290 | 7.9% | cbioportal |
| 15 | AHNAK2 | Ssm | 19 | 290 | 6.6% | cbioportal |
| 16 | HMCN1 | Ssm | 19 | 290 | 6.6% | cbioportal |
| 17 | LRP2 | Ssm | 18 | 290 | 6.2% | cbioportal |
| 18 | RYR3 | Ssm | 18 | 290 | 6.2% | cbioportal |
| 20 | FRG1BP | Ssm | 17 | 290 | 5.9% | cbioportal |
| 19 | ATRX | Ssm | 17 | 290 | 5.9% | cbioportal |
| 21 | DNAH5 | Ssm | 16 | 290 | 5.5% | cbioportal |
| 22 | OBSCN | Ssm | 16 | 290 | 5.5% | cbioportal |
| 24 | TCHH | Ssm | 16 | 290 | 5.5% | cbioportal |
| 23 | PKHD1 | Ssm | 16 | 290 | 5.5% | cbioportal |
| 25 | USH2A | Ssm | 16 | 290 | 5.5% | cbioportal |
| 27 | KEL | Ssm | 15 | 290 | 5.2% | cbioportal |
| 26 | IDH1 | Ssm | 15 | 290 | 5.2% | cbioportal |
| 31 | COL6A3 | Ssm | 14 | 290 | 4.8% | cbioportal |
| 34 | SYNE1 | Ssm | 14 | 290 | 4.8% | cbioportal |
| 29 | APOB | Ssm | 14 | 290 | 4.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07