Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
127 cases with simple somatic mutation data · 127 cases total · 2026-01-07 · mapped to Hepatocellular Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TERT |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 68 |
| 127 |
| 53.5% |
| cbioportal |
| 2 | CTNNB1 | Ssm | 44 | 127 | 34.6% | cbioportal |
| 3 | TP53 | Ssm | 39 | 127 | 30.7% | cbioportal |
| 4 | ARID1A | Ssm | 17 | 127 | 13.4% | cbioportal |
| 5 | TSC2 | Ssm | 11 | 127 | 8.7% | cbioportal |
| 50 | PREX2 | Ssm | 3 | 36 | 8.3% | cbioportal |
| 6 | NFE2L2 | Ssm | 8 | 127 | 6.3% | cbioportal |
| 11 | SF3B1 | Ssm | 7 | 127 | 5.5% | cbioportal |
| 9 | JAK1 | Ssm | 7 | 127 | 5.5% | cbioportal |
| 7 | APC | Ssm | 7 | 127 | 5.5% | cbioportal |
| 10 | KMT2D | Ssm | 7 | 127 | 5.5% | cbioportal |
| 8 | AXIN1 | Ssm | 7 | 127 | 5.5% | cbioportal |
| 12 | ARID2 | Ssm | 6 | 127 | 4.7% | cbioportal |
| 13 | BAP1 | Ssm | 6 | 127 | 4.7% | cbioportal |
| 23 | ZRSR2 | Ssm | 5 | 106 | 4.7% | cbioportal |
| 21 | RB1 | Ssm | 5 | 127 | 3.9% | cbioportal |
| 19 | NOTCH1 | Ssm | 5 | 127 | 3.9% | cbioportal |
| 20 | PTPRT | Ssm | 5 | 127 | 3.9% | cbioportal |
| 18 | KMT2A | Ssm | 5 | 127 | 3.9% | cbioportal |
| 16 | IGF1R | Ssm | 5 | 127 | 3.9% | cbioportal |
| 17 | KDR | Ssm | 5 | 127 | 3.9% | cbioportal |
| 14 | ALK | Ssm | 5 | 127 | 3.9% | cbioportal |
| 22 | SETD2 | Ssm | 5 | 127 | 3.9% | cbioportal |
| 15 | CDKN1A | Ssm | 5 | 127 | 3.9% | cbioportal |
| 35 | ZFHX3 | Ssm | 4 | 106 | 3.8% | cbioportal |
| 29 | NOTCH4 | Ssm | 4 | 127 | 3.1% | cbioportal |
| 24 | CDKN2A | Ssm | 4 | 127 | 3.1% | cbioportal |
| 26 | KDM5A | Ssm | 4 | 127 | 3.1% | cbioportal |
| 25 | CREBBP | Ssm | 4 | 127 | 3.1% | cbioportal |
| 30 | NTRK2 | Ssm | 4 | 127 | 3.1% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07