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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
2,653 cases with simple somatic mutation data · 2,653 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 1,429 |
| 2,653 |
| 53.9% |
| cbioportal |
| 59 | TTN | Ssm | 90 | 231 | 39% | cbioportal |
| 65 | RYR2 | Ssm | 85 | 231 | 36.8% | cbioportal |
| 2 | EGFR | Ssm | 866 | 2,653 | 32.6% | cbioportal |
| 82 | MUC16 | Ssm | 72 | 231 | 31.2% | cbioportal |
| 3 | KRAS | Ssm | 787 | 2,653 | 29.7% | cbioportal |
| 90 | CSMD3 | Ssm | 65 | 231 | 28.1% | cbioportal |
| 94 | LRP1B | Ssm | 64 | 231 | 27.7% | cbioportal |
| 102 | USH2A | Ssm | 61 | 231 | 26.4% | cbioportal |
| 119 | CSMD1 | Ssm | 54 | 231 | 23.4% | cbioportal |
| 125 | FSIP2 | Ssm | 52 | 231 | 22.5% | cbioportal |
| 144 | EYS | Ssm | 45 | 231 | 19.5% | cbioportal |
| 149 | PCDH15 | Ssm | 43 | 231 | 18.6% | cbioportal |
| 152 | ZFHX4 | Ssm | 43 | 231 | 18.6% | cbioportal |
| 153 | ZNF536 | Ssm | 43 | 231 | 18.6% | cbioportal |
| 150 | SPTA1 | Ssm | 43 | 231 | 18.6% | cbioportal |
| 154 | ABCA13 | Ssm | 42 | 231 | 18.2% | cbioportal |
| 164 | CACNA1E | Ssm | 41 | 231 | 17.7% | cbioportal |
| 168 | XIRP2 | Ssm | 41 | 231 | 17.7% | cbioportal |
| 4 | STK11 | Ssm | 450 | 2,653 | 17% | cbioportal |
| 183 | FAT3 | Ssm | 38 | 231 | 16.5% | cbioportal |
| 186 | RYR1 | Ssm | 38 | 231 | 16.5% | cbioportal |
| 182 | ASXL3 | Ssm | 38 | 231 | 16.5% | cbioportal |
| 189 | COL11A1 | Ssm | 37 | 231 | 16% | cbioportal |
| 191 | MUC17 | Ssm | 37 | 231 | 16% | cbioportal |
| 198 | PAPPA2 | Ssm | 36 | 231 | 15.6% | cbioportal |
| 200 | ANK2 | Ssm | 35 | 231 | 15.2% | cbioportal |
| 5 | KEAP1 | Ssm | 400 | 2,653 | 15.1% | cbioportal |
| 6 | RBM10 | Ssm | 294 | 2,653 | 11.1% | cbioportal |
| 7 | PTPRD | Ssm | 270 | 2,653 | 10.2% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07