Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
523 cases with simple somatic mutation data · 530 cases total · 2026-01-19 · mapped to Diffuse Glioma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | IDH1 | Ssm | 405 | 523 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 77.4% |
| cbioportal |
| 2 | TP53 | Ssm | 250 | 523 | 47.8% | cbioportal |
| 3 | ATRX | Ssm | 192 | 523 | 36.7% | cbioportal |
| 4 | CIC | Ssm | 112 | 523 | 21.4% | cbioportal |
| 5 | TTN | Ssm | 56 | 523 | 10.7% | cbioportal |
| 6 | FUBP1 | Ssm | 46 | 523 | 8.8% | cbioportal |
| 7 | PIK3CA | Ssm | 43 | 523 | 8.2% | cbioportal |
| 8 | NOTCH1 | Ssm | 38 | 523 | 7.3% | cbioportal |
| 9 | MUC16 | Ssm | 33 | 523 | 6.3% | cbioportal |
| 10 | EGFR | Ssm | 31 | 523 | 5.9% | cbioportal |
| 11 | NF1 | Ssm | 30 | 523 | 5.7% | cbioportal |
| 12 | PTEN | Ssm | 25 | 523 | 4.8% | cbioportal |
| 13 | PIK3R1 | Ssm | 23 | 523 | 4.4% | cbioportal |
| 14 | SMARCA4 | Ssm | 23 | 523 | 4.4% | cbioportal |
| 15 | IDH2 | Ssm | 21 | 523 | 4% | cbioportal |
| 16 | RYR2 | Ssm | 20 | 523 | 3.8% | cbioportal |
| 17 | NIPBL | Ssm | 18 | 523 | 3.4% | cbioportal |
| 18 | ZBTB20 | Ssm | 17 | 523 | 3.3% | cbioportal |
| 19 | FLG | Ssm | 16 | 523 | 3.1% | cbioportal |
| 20 | ARID1A | Ssm | 15 | 523 | 2.9% | cbioportal |
| 21 | BCOR | Ssm | 15 | 523 | 2.9% | cbioportal |
| 23 | PCLO | Ssm | 14 | 523 | 2.7% | cbioportal |
| 24 | TCF12 | Ssm | 14 | 523 | 2.7% | cbioportal |
| 22 | MUC17 | Ssm | 14 | 523 | 2.7% | cbioportal |
| 26 | ZNF292 | Ssm | 13 | 523 | 2.5% | cbioportal |
| 25 | LRP2 | Ssm | 13 | 523 | 2.5% | cbioportal |
| 29 | FAT2 | Ssm | 12 | 523 | 2.3% | cbioportal |
| 28 | ARID2 | Ssm | 12 | 523 | 2.3% | cbioportal |
| 27 | APOB | Ssm | 12 | 523 | 2.3% | cbioportal |
| 31 | HMCN1 | Ssm | 12 | 523 | 2.3% | cbioportal |
Data updated 21 days agoSource updated 2026-01-19