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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
559 cases with simple somatic mutation data · 571 cases total · 2026-01-13 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 | Ssm | 284 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 559 |
| 50.8% |
| cbioportal |
| 2 | TTN | Ssm | 245 | 559 | 43.8% | cbioportal |
| 3 | MUC16 | Ssm | 225 | 559 | 40.3% | cbioportal |
| 4 | CSMD3 | Ssm | 213 | 559 | 38.1% | cbioportal |
| 5 | RYR2 | Ssm | 200 | 559 | 35.8% | cbioportal |
| 6 | LRP1B | Ssm | 184 | 559 | 32.9% | cbioportal |
| 7 | ZFHX4 | Ssm | 172 | 559 | 30.8% | cbioportal |
| 8 | USH2A | Ssm | 168 | 559 | 30.1% | cbioportal |
| 9 | KRAS | Ssm | 149 | 559 | 26.7% | cbioportal |
| 10 | XIRP2 | Ssm | 134 | 559 | 24% | cbioportal |
| 11 | FLG | Ssm | 129 | 559 | 23.1% | cbioportal |
| 12 | SPTA1 | Ssm | 124 | 559 | 22.2% | cbioportal |
| 13 | NAV3 | Ssm | 117 | 559 | 20.9% | cbioportal |
| 14 | COL11A1 | Ssm | 114 | 559 | 20.4% | cbioportal |
| 15 | ZNF536 | Ssm | 112 | 559 | 20% | cbioportal |
| 16 | FAT3 | Ssm | 107 | 559 | 19.1% | cbioportal |
| 17 | ANK2 | Ssm | 106 | 559 | 19% | cbioportal |
| 19 | PCLO | Ssm | 103 | 559 | 18.4% | cbioportal |
| 18 | CSMD1 | Ssm | 103 | 559 | 18.4% | cbioportal |
| 20 | APOB | Ssm | 101 | 559 | 18.1% | cbioportal |
| 21 | PCDH15 | Ssm | 101 | 559 | 18.1% | cbioportal |
| 22 | KEAP1 | Ssm | 98 | 559 | 17.5% | cbioportal |
| 24 | MUC17 | Ssm | 97 | 559 | 17.4% | cbioportal |
| 23 | ADAMTS12 | Ssm | 97 | 559 | 17.4% | cbioportal |
| 25 | TNR | Ssm | 95 | 559 | 17% | cbioportal |
| 26 | DNAH9 | Ssm | 93 | 559 | 16.6% | cbioportal |
| 28 | RP1L1 | Ssm | 90 | 559 | 16.1% | cbioportal |
| 27 | PAPPA2 | Ssm | 90 | 559 | 16.1% | cbioportal |
| 30 | RYR3 | Ssm | 89 | 559 | 15.9% | cbioportal |
| 29 | ADGRG4 | Ssm | 89 | 559 | 15.9% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13