Neoplasm by Site — Genomics

Neoplasm by Site — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) hnsc_tcga_pan_can_atlas_2018TCGA

515 cases with simple somatic mutation data · 523 cases total · 2026-06-23 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

1	TP53	Ssm	357	515	69.3%	cbioportal
2	TTN	Ssm	211	515	41%	cbioportal
3	FAT1	Ssm	111	515	21.6%	cbioportal
4	CDKN2A	Ssm	105	515	20.4%	cbioportal
5	MUC16	Ssm	101	515	19.6%	cbioportal
6	CSMD3	Ssm	97	515	18.8%	cbioportal
7	PIK3CA	Ssm	90	515	17.5%	cbioportal
8	NOTCH1	Ssm	88	515	17.1%	cbioportal
9	LRP1B	Ssm	85	515	16.5%	cbioportal
10	SYNE1	Ssm	85	515	16.5%	cbioportal
11	PCLO	Ssm	79	515	15.3%	cbioportal
12	KMT2D	Ssm	77	515	15%	cbioportal
13	DNAH5	Ssm	70	515	13.6%	cbioportal
14	FLG	Ssm	67	515	13%	cbioportal
15	USH2A	Ssm	63	515	12.2%	cbioportal
17	RYR2	Ssm	60	515	11.7%	cbioportal
16	NSD1	Ssm	60	515	11.7%	cbioportal
18	CASP8	Ssm	55	515	10.7%	cbioportal
20	PKHD1L1	Ssm	53	515	10.3%	cbioportal
19	DMD	Ssm	53	515	10.3%	cbioportal
21	XIRP2	Ssm	52	515	10.1%	cbioportal
22	FAM135B	Ssm	51	515	9.9%	cbioportal
23	HUWE1	Ssm	50	515	9.7%	cbioportal
24	SI	Ssm	50	515	9.7%	cbioportal
26	RELN	Ssm	48	515	9.3%	cbioportal
25	COL11A1	Ssm	48	515	9.3%	cbioportal
27	PAPPA2	Ssm	46	515	8.9%	cbioportal
28	AHNAK	Ssm	45	515	8.7%	cbioportal
30	PLEC	Ssm	44	515	8.5%	cbioportal
29	PCDH15	Ssm	44	515	8.5%	cbioportal