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CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
185 cases with simple somatic mutation data · 186 cases total · 2026-01-07 · mapped to Esophageal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 153 |
| 185 |
| 82.7% |
| cbioportal |
| 2 | TTN | Ssm | 97 | 185 | 52.4% | cbioportal |
| 3 | MUC16 | Ssm | 51 | 185 | 27.6% | cbioportal |
| 4 | SYNE1 | Ssm | 44 | 185 | 23.8% | cbioportal |
| 5 | CSMD3 | Ssm | 40 | 185 | 21.6% | cbioportal |
| 6 | DNAH5 | Ssm | 35 | 185 | 18.9% | cbioportal |
| 7 | HMCN1 | Ssm | 34 | 185 | 18.4% | cbioportal |
| 8 | LRP1B | Ssm | 33 | 185 | 17.8% | cbioportal |
| 10 | KMT2D | Ssm | 32 | 185 | 17.3% | cbioportal |
| 9 | FLG | Ssm | 32 | 185 | 17.3% | cbioportal |
| 11 | RYR2 | Ssm | 31 | 185 | 16.8% | cbioportal |
| 12 | MUC4 | Ssm | 29 | 185 | 15.7% | cbioportal |
| 14 | USH2A | Ssm | 29 | 185 | 15.7% | cbioportal |
| 13 | PCLO | Ssm | 29 | 185 | 15.7% | cbioportal |
| 16 | OBSCN | Ssm | 27 | 185 | 14.6% | cbioportal |
| 15 | CSMD1 | Ssm | 27 | 185 | 14.6% | cbioportal |
| 17 | PKHD1L1 | Ssm | 26 | 185 | 14.1% | cbioportal |
| 20 | SPTA1 | Ssm | 25 | 185 | 13.5% | cbioportal |
| 18 | FAT3 | Ssm | 25 | 185 | 13.5% | cbioportal |
| 19 | FAT4 | Ssm | 25 | 185 | 13.5% | cbioportal |
| 21 | MUC12 | Ssm | 24 | 185 | 13% | cbioportal |
| 23 | RYR3 | Ssm | 23 | 185 | 12.4% | cbioportal |
| 22 | DYNC2H1 | Ssm | 23 | 185 | 12.4% | cbioportal |
| 24 | XIRP2 | Ssm | 23 | 185 | 12.4% | cbioportal |
| 25 | ADGRV1 | Ssm | 22 | 185 | 11.9% | cbioportal |
| 26 | DST | Ssm | 22 | 185 | 11.9% | cbioportal |
| 27 | ATM | Ssm | 21 | 185 | 11.4% | cbioportal |
| 29 | EYS | Ssm | 21 | 185 | 11.4% | cbioportal |
| 33 | ZNF804B | Ssm | 21 | 185 | 11.4% | cbioportal |
| 30 | NEB | Ssm | 21 | 185 | 11.4% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07