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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
447 cases with simple somatic mutation data · 447 cases total · 2026-01-12 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 257 |
| 447 |
| 57.5% |
| cbioportal |
| 2 | TTN | Ssm | 209 | 447 | 46.8% | cbioportal |
| 3 | CSMD3 | Ssm | 155 | 447 | 34.7% | cbioportal |
| 4 | RYR2 | Ssm | 154 | 447 | 34.5% | cbioportal |
| 5 | LRP1B | Ssm | 130 | 447 | 29.1% | cbioportal |
| 6 | ZFHX4 | Ssm | 109 | 447 | 24.4% | cbioportal |
| 7 | KRAS | Ssm | 103 | 447 | 23% | cbioportal |
| 8 | USH2A | Ssm | 96 | 447 | 21.5% | cbioportal |
| 9 | MUC16 | Ssm | 91 | 447 | 20.4% | cbioportal |
| 10 | RYR3 | Ssm | 89 | 447 | 19.9% | cbioportal |
| 11 | UNC80 | Ssm | 88 | 447 | 19.7% | cbioportal |
| 12 | CSMD1 | Ssm | 85 | 447 | 19% | cbioportal |
| 13 | XIRP2 | Ssm | 81 | 447 | 18.1% | cbioportal |
| 14 | LRP2 | Ssm | 79 | 447 | 17.7% | cbioportal |
| 15 | SI | Ssm | 78 | 447 | 17.4% | cbioportal |
| 16 | CACNA1E | Ssm | 77 | 447 | 17.2% | cbioportal |
| 17 | OBSCN | Ssm | 75 | 447 | 16.8% | cbioportal |
| 20 | SYNE1 | Ssm | 74 | 447 | 16.6% | cbioportal |
| 18 | COL22A1 | Ssm | 74 | 447 | 16.6% | cbioportal |
| 19 | SPTA1 | Ssm | 74 | 447 | 16.6% | cbioportal |
| 21 | CSMD2 | Ssm | 73 | 447 | 16.3% | cbioportal |
| 22 | EYS | Ssm | 73 | 447 | 16.3% | cbioportal |
| 23 | RELN | Ssm | 70 | 447 | 15.7% | cbioportal |
| 24 | CNTNAP5 | Ssm | 69 | 447 | 15.4% | cbioportal |
| 25 | CNTNAP2 | Ssm | 68 | 447 | 15.2% | cbioportal |
| 26 | NEB | Ssm | 68 | 447 | 15.2% | cbioportal |
| 27 | DNAH9 | Ssm | 67 | 447 | 15% | cbioportal |
| 28 | FAM135B | Ssm | 66 | 447 | 14.8% | cbioportal |
| 29 | PAPPA2 | Ssm | 65 | 447 | 14.5% | cbioportal |
| 30 | FSIP2 | Ssm | 64 | 447 | 14.3% | cbioportal |
Data updated 21 days agoSource updated 2026-01-12