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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
375 cases with simple somatic mutation data · 537 cases total · 2026-01-13 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | VHL | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 172 |
| 375 |
| 45.9% |
| cbioportal |
| 2 | PBRM1 | Ssm | 147 | 375 | 39.2% | cbioportal |
| 3 | TTN | Ssm | 63 | 375 | 16.8% | cbioportal |
| 4 | SETD2 | Ssm | 46 | 375 | 12.3% | cbioportal |
| 5 | BAP1 | Ssm | 40 | 375 | 10.7% | cbioportal |
| 6 | MUC16 | Ssm | 29 | 375 | 7.7% | cbioportal |
| 7 | MTOR | Ssm | 27 | 375 | 7.2% | cbioportal |
| 8 | KDM5C | Ssm | 20 | 375 | 5.3% | cbioportal |
| 10 | DST | Ssm | 19 | 375 | 5.1% | cbioportal |
| 9 | DNAH9 | Ssm | 19 | 375 | 5.1% | cbioportal |
| 12 | CSMD3 | Ssm | 17 | 375 | 4.5% | cbioportal |
| 11 | ATM | Ssm | 17 | 375 | 4.5% | cbioportal |
| 16 | LRP2 | Ssm | 16 | 375 | 4.3% | cbioportal |
| 13 | FBN2 | Ssm | 16 | 375 | 4.3% | cbioportal |
| 15 | KMT2C | Ssm | 16 | 375 | 4.3% | cbioportal |
| 14 | HMCN1 | Ssm | 16 | 375 | 4.3% | cbioportal |
| 17 | AHNAK2 | Ssm | 15 | 375 | 4% | cbioportal |
| 20 | SYNE1 | Ssm | 14 | 375 | 3.7% | cbioportal |
| 21 | USH2A | Ssm | 14 | 375 | 3.7% | cbioportal |
| 19 | SPEN | Ssm | 14 | 375 | 3.7% | cbioportal |
| 18 | ANK3 | Ssm | 14 | 375 | 3.7% | cbioportal |
| 25 | PTEN | Ssm | 13 | 375 | 3.5% | cbioportal |
| 24 | PCLO | Ssm | 13 | 375 | 3.5% | cbioportal |
| 23 | MUC17 | Ssm | 13 | 375 | 3.5% | cbioportal |
| 22 | DNAH2 | Ssm | 13 | 375 | 3.5% | cbioportal |
| 27 | FLG | Ssm | 12 | 375 | 3.2% | cbioportal |
| 29 | PKHD1L1 | Ssm | 12 | 375 | 3.2% | cbioportal |
| 28 | LRP1B | Ssm | 12 | 375 | 3.2% | cbioportal |
| 26 | ARID1A | Ssm | 12 | 375 | 3.2% | cbioportal |
| 30 | XIRP2 | Ssm | 12 | 375 | 3.2% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13