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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
78 cases with simple somatic mutation data · 78 cases total · 2026-01-07 · mapped to Gastroesophageal Junction Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 36 |
| 78 |
| 46.2% |
| cbioportal |
| 2 | TTN | Ssm | 34 | 78 | 43.6% | cbioportal |
| 3 | ARID1A | Ssm | 17 | 78 | 21.8% | cbioportal |
| 4 | MUC16 | Ssm | 14 | 78 | 17.9% | cbioportal |
| 6 | CSMD3 | Ssm | 13 | 78 | 16.7% | cbioportal |
| 8 | ZFHX4 | Ssm | 13 | 78 | 16.7% | cbioportal |
| 7 | PCLO | Ssm | 13 | 78 | 16.7% | cbioportal |
| 5 | COL11A1 | Ssm | 13 | 78 | 16.7% | cbioportal |
| 9 | LRP1B | Ssm | 12 | 78 | 15.4% | cbioportal |
| 10 | SYNE1 | Ssm | 12 | 78 | 15.4% | cbioportal |
| 11 | CDH1 | Ssm | 11 | 78 | 14.1% | cbioportal |
| 12 | HMCN1 | Ssm | 11 | 78 | 14.1% | cbioportal |
| 13 | DNAH5 | Ssm | 10 | 78 | 12.8% | cbioportal |
| 15 | PIK3CA | Ssm | 10 | 78 | 12.8% | cbioportal |
| 14 | FAT4 | Ssm | 10 | 78 | 12.8% | cbioportal |
| 20 | PCDH9 | Ssm | 9 | 78 | 11.5% | cbioportal |
| 21 | USH2A | Ssm | 9 | 78 | 11.5% | cbioportal |
| 16 | APC | Ssm | 9 | 78 | 11.5% | cbioportal |
| 17 | DNAH7 | Ssm | 9 | 78 | 11.5% | cbioportal |
| 19 | FREM2 | Ssm | 9 | 78 | 11.5% | cbioportal |
| 18 | FAT3 | Ssm | 9 | 78 | 11.5% | cbioportal |
| 27 | LRBA | Ssm | 8 | 78 | 10.3% | cbioportal |
| 34 | SACS | Ssm | 8 | 78 | 10.3% | cbioportal |
| 24 | DMD | Ssm | 8 | 78 | 10.3% | cbioportal |
| 23 | DCHS2 | Ssm | 8 | 78 | 10.3% | cbioportal |
| 22 | AKAP6 | Ssm | 8 | 78 | 10.3% | cbioportal |
| 35 | UNC13C | Ssm | 8 | 78 | 10.3% | cbioportal |
| 33 | NRK | Ssm | 8 | 78 | 10.3% | cbioportal |
| 32 | NEB | Ssm | 8 | 78 | 10.3% | cbioportal |
| 31 | NBEA | Ssm | 8 | 78 | 10.3% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07