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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
240 cases with simple somatic mutation data · 240 cases total · 2026-01-12 · mapped to Lung Non-Small Cell Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 141 |
| 240 |
| 58.8% |
| cbioportal |
| 2 | KRAS | Ssm | 86 | 240 | 35.8% | cbioportal |
| 4 | STK11 | Ssm | 53 | 240 | 22.1% | cbioportal |
| 3 | KEAP1 | Ssm | 53 | 240 | 22.1% | cbioportal |
| 5 | PTPRD | Ssm | 30 | 240 | 12.5% | cbioportal |
| 6 | SMARCA4 | Ssm | 27 | 240 | 11.3% | cbioportal |
| 7 | EGFR | Ssm | 26 | 240 | 10.8% | cbioportal |
| 8 | RBM10 | Ssm | 26 | 240 | 10.8% | cbioportal |
| 12 | PTPRT | Ssm | 25 | 240 | 10.4% | cbioportal |
| 9 | EPHA5 | Ssm | 25 | 240 | 10.4% | cbioportal |
| 11 | NF1 | Ssm | 25 | 240 | 10.4% | cbioportal |
| 10 | KMT2C | Ssm | 25 | 240 | 10.4% | cbioportal |
| 14 | FAT1 | Ssm | 24 | 240 | 10% | cbioportal |
| 13 | EPHA3 | Ssm | 24 | 240 | 10% | cbioportal |
| 15 | ARID1A | Ssm | 23 | 240 | 9.6% | cbioportal |
| 16 | KMT2D | Ssm | 23 | 240 | 9.6% | cbioportal |
| 21 | MGA | Ssm | 17 | 184 | 9.2% | cbioportal |
| 27 | EPHA7 | Ssm | 15 | 184 | 8.2% | cbioportal |
| 17 | ATM | Ssm | 19 | 240 | 7.9% | cbioportal |
| 18 | PIK3CG | Ssm | 19 | 240 | 7.9% | cbioportal |
| 19 | CDKN2A | Ssm | 18 | 240 | 7.5% | cbioportal |
| 22 | NOTCH4 | Ssm | 17 | 240 | 7.1% | cbioportal |
| 20 | HGF | Ssm | 17 | 240 | 7.1% | cbioportal |
| 23 | TERT | Ssm | 17 | 240 | 7.1% | cbioportal |
| 24 | ERBB4 | Ssm | 16 | 240 | 6.7% | cbioportal |
| 25 | RB1 | Ssm | 16 | 240 | 6.7% | cbioportal |
| 26 | SETD2 | Ssm | 16 | 240 | 6.7% | cbioportal |
| 42 | PGR | Ssm | 12 | 184 | 6.5% | cbioportal |
| 45 | ZFHX3 | Ssm | 12 | 184 | 6.5% | cbioportal |
| 31 | PIK3CA | Ssm | 14 | 240 | 5.8% | cbioportal |
Data updated 21 days agoSource updated 2026-01-12