Other
Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
70 cases with simple somatic mutation data · 70 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | PIK3CA |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 35 |
| 70 |
| 50% |
| cbioportal |
| 2 | TP53 | Ssm | 19 | 70 | 27.1% | cbioportal |
| 3 | CDH1 | Ssm | 15 | 70 | 21.4% | cbioportal |
| 4 | GATA3 | Ssm | 12 | 70 | 17.1% | cbioportal |
| 5 | MAP3K1 | Ssm | 12 | 70 | 17.1% | cbioportal |
| 6 | KMT2C | Ssm | 10 | 70 | 14.3% | cbioportal |
| 8 | MDC1 | Ssm | 8 | 70 | 11.4% | cbioportal |
| 7 | ERBB2 | Ssm | 8 | 70 | 11.4% | cbioportal |
| 10 | MED12 | Ssm | 7 | 70 | 10% | cbioportal |
| 11 | PTEN | Ssm | 7 | 70 | 10% | cbioportal |
| 9 | BRCA2 | Ssm | 7 | 70 | 10% | cbioportal |
| 14 | RUNX1 | Ssm | 6 | 70 | 8.6% | cbioportal |
| 12 | ALK | Ssm | 6 | 70 | 8.6% | cbioportal |
| 13 | ATM | Ssm | 6 | 70 | 8.6% | cbioportal |
| 15 | TSC2 | Ssm | 6 | 70 | 8.6% | cbioportal |
| 20 | POLE | Ssm | 5 | 70 | 7.1% | cbioportal |
| 16 | BRCA1 | Ssm | 5 | 70 | 7.1% | cbioportal |
| 19 | NCOR1 | Ssm | 5 | 70 | 7.1% | cbioportal |
| 17 | EGFR | Ssm | 5 | 70 | 7.1% | cbioportal |
| 22 | TGFBR2 | Ssm | 5 | 70 | 7.1% | cbioportal |
| 21 | PTPRD | Ssm | 5 | 70 | 7.1% | cbioportal |
| 18 | ESR1 | Ssm | 5 | 70 | 7.1% | cbioportal |
| 28 | NOTCH2 | Ssm | 4 | 70 | 5.7% | cbioportal |
| 25 | FANCA | Ssm | 4 | 70 | 5.7% | cbioportal |
| 29 | SF3B1 | Ssm | 4 | 70 | 5.7% | cbioportal |
| 30 | SPEN | Ssm | 4 | 70 | 5.7% | cbioportal |
| 27 | MAP2K4 | Ssm | 4 | 70 | 5.7% | cbioportal |
| 23 | ATR | Ssm | 4 | 70 | 5.7% | cbioportal |
| 26 | FAT1 | Ssm | 4 | 70 | 5.7% | cbioportal |
| 24 | ERBB3 | Ssm | 4 | 70 | 5.7% | cbioportal |
Data updated 22 days agoSource updated 2026-01-05