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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
440 cases with simple somatic mutation data · 448 cases total · 2026-06-04 · mapped to Cutaneous Melanoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 1 |
| TTN |
| Ssm |
| 352 |
| 440 |
| 80% |
| cbioportal |
| 2 | MUC16 | Ssm | 325 | 440 | 73.9% | cbioportal |
| 3 | DNAH5 | Ssm | 248 | 440 | 56.4% | cbioportal |
| 4 | BRAF | Ssm | 233 | 440 | 53% | cbioportal |
| 5 | PCLO | Ssm | 216 | 440 | 49.1% | cbioportal |
| 6 | LRP1B | Ssm | 206 | 440 | 46.8% | cbioportal |
| 7 | ADGRV1 | Ssm | 198 | 440 | 45% | cbioportal |
| 8 | PKHD1L1 | Ssm | 185 | 440 | 42% | cbioportal |
| 9 | DNAH7 | Ssm | 179 | 440 | 40.7% | cbioportal |
| 10 | MGAM | Ssm | 176 | 440 | 40% | cbioportal |
| 11 | CSMD1 | Ssm | 175 | 440 | 39.8% | cbioportal |
| 12 | CSMD2 | Ssm | 174 | 440 | 39.5% | cbioportal |
| 13 | FAT4 | Ssm | 171 | 440 | 38.9% | cbioportal |
| 14 | ANK3 | Ssm | 167 | 440 | 38% | cbioportal |
| 15 | CSMD3 | Ssm | 164 | 440 | 37.3% | cbioportal |
| 16 | RP1 | Ssm | 163 | 440 | 37% | cbioportal |
| 17 | XIRP2 | Ssm | 160 | 440 | 36.4% | cbioportal |
| 18 | HYDIN | Ssm | 159 | 440 | 36.1% | cbioportal |
| 19 | THSD7B | Ssm | 157 | 440 | 35.7% | cbioportal |
| 21 | USH2A | Ssm | 156 | 440 | 35.5% | cbioportal |
| 20 | DNAH9 | Ssm | 156 | 440 | 35.5% | cbioportal |
| 22 | DNAH8 | Ssm | 154 | 440 | 35% | cbioportal |
| 23 | DSCAM | Ssm | 151 | 440 | 34.3% | cbioportal |
| 24 | FLG | Ssm | 150 | 440 | 34.1% | cbioportal |
| 25 | SYNE1 | Ssm | 150 | 440 | 34.1% | cbioportal |
| 26 | APOB | Ssm | 146 | 440 | 33.2% | cbioportal |
| 27 | ZFHX4 | Ssm | 146 | 440 | 33.2% | cbioportal |
| 28 | RYR1 | Ssm | 145 | 440 | 33% | cbioportal |
| 29 | DNAH3 | Ssm | 143 | 440 | 32.5% | cbioportal |
| 30 | MXRA5 | Ssm | 143 | 440 | 32.5% | cbioportal |
Data updated 21 days agoSource updated 2026-06-04