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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
471 cases with simple somatic mutation data · 471 cases total · 2026-01-07 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 345 |
| 471 |
| 73.2% |
| cbioportal |
| 2 | APC | Ssm | 325 | 471 | 69% | cbioportal |
| 3 | KRAS | Ssm | 238 | 471 | 50.5% | cbioportal |
| 4 | PIK3CA | Ssm | 88 | 471 | 18.7% | cbioportal |
| 5 | SMAD4 | Ssm | 69 | 471 | 14.6% | cbioportal |
| 6 | BRAF | Ssm | 58 | 471 | 12.3% | cbioportal |
| 7 | FBXW7 | Ssm | 51 | 471 | 10.8% | cbioportal |
| 12 | TCF7L2 | Ssm | 36 | 392 | 9.2% | cbioportal |
| 8 | SOX9 | Ssm | 39 | 471 | 8.3% | cbioportal |
| 9 | RNF43 | Ssm | 38 | 471 | 8.1% | cbioportal |
| 11 | KMT2D | Ssm | 36 | 471 | 7.6% | cbioportal |
| 10 | ARID1A | Ssm | 36 | 471 | 7.6% | cbioportal |
| 13 | PTPRS | Ssm | 33 | 471 | 7% | cbioportal |
| 102 | KMT2B | Ssm | 10 | 153 | 6.5% | cbioportal |
| 14 | CTNNB1 | Ssm | 28 | 471 | 5.9% | cbioportal |
| 23 | ZFHX3 | Ssm | 22 | 392 | 5.6% | cbioportal |
| 15 | ERBB4 | Ssm | 26 | 471 | 5.5% | cbioportal |
| 16 | ATM | Ssm | 25 | 471 | 5.3% | cbioportal |
| 17 | PTPRT | Ssm | 25 | 471 | 5.3% | cbioportal |
| 18 | AMER1 | Ssm | 24 | 471 | 5.1% | cbioportal |
| 19 | NF1 | Ssm | 24 | 471 | 5.1% | cbioportal |
| 21 | SMARCA4 | Ssm | 23 | 471 | 4.9% | cbioportal |
| 20 | PTEN | Ssm | 23 | 471 | 4.9% | cbioportal |
| 32 | ANKRD11 | Ssm | 19 | 392 | 4.8% | cbioportal |
| 22 | ERBB3 | Ssm | 22 | 471 | 4.7% | cbioportal |
| 151 | INPPL1 | Ssm | 7 | 153 | 4.6% | cbioportal |
| 162 | PREX2 | Ssm | 7 | 153 | 4.6% | cbioportal |
| 26 | FLT4 | Ssm | 21 | 471 | 4.5% | cbioportal |
| 25 | BRCA2 | Ssm | 21 | 471 | 4.5% | cbioportal |
| 24 | BCOR | Ssm | 21 | 471 | 4.5% | cbioportal |
Data updated 21 days agoSource updated 2026-01-07