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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
47 cases with simple somatic mutation data · 47 cases total · 2026-01-16 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | KRAS |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 45 |
| 47 |
| 95.7% |
| cbioportal |
| 2 | APC | Ssm | 39 | 47 | 83% | cbioportal |
| 3 | TP53 | Ssm | 20 | 47 | 42.6% | cbioportal |
| 5 | TCF7L2 | Ssm | 17 | 45 | 37.8% | cbioportal |
| 4 | PIK3CA | Ssm | 17 | 47 | 36.2% | cbioportal |
| 6 | NRAS | Ssm | 14 | 47 | 29.8% | cbioportal |
| 7 | PTPRS | Ssm | 14 | 47 | 29.8% | cbioportal |
| 8 | FBXW7 | Ssm | 13 | 47 | 27.7% | cbioportal |
| 9 | ARID1A | Ssm | 12 | 47 | 25.5% | cbioportal |
| 10 | FLT4 | Ssm | 12 | 47 | 25.5% | cbioportal |
| 13 | SOX9 | Ssm | 11 | 47 | 23.4% | cbioportal |
| 11 | CREBBP | Ssm | 11 | 47 | 23.4% | cbioportal |
| 12 | SMAD4 | Ssm | 11 | 47 | 23.4% | cbioportal |
| 22 | KMT2B | Ssm | 9 | 40 | 22.5% | cbioportal |
| 18 | POLE | Ssm | 10 | 47 | 21.3% | cbioportal |
| 19 | PTEN | Ssm | 10 | 47 | 21.3% | cbioportal |
| 15 | FAT1 | Ssm | 10 | 47 | 21.3% | cbioportal |
| 16 | KMT2A | Ssm | 10 | 47 | 21.3% | cbioportal |
| 14 | AMER1 | Ssm | 10 | 47 | 21.3% | cbioportal |
| 17 | NOTCH3 | Ssm | 10 | 47 | 21.3% | cbioportal |
| 25 | ZFHX3 | Ssm | 9 | 45 | 20% | cbioportal |
| 20 | AXIN2 | Ssm | 9 | 47 | 19.1% | cbioportal |
| 24 | SPEN | Ssm | 9 | 47 | 19.1% | cbioportal |
| 23 | KMT2D | Ssm | 9 | 47 | 19.1% | cbioportal |
| 21 | BCOR | Ssm | 9 | 47 | 19.1% | cbioportal |
| 39 | INPPL1 | Ssm | 7 | 40 | 17.5% | cbioportal |
| 30 | PIK3R1 | Ssm | 8 | 47 | 17% | cbioportal |
| 28 | EPHA5 | Ssm | 8 | 47 | 17% | cbioportal |
| 27 | CIC | Ssm | 8 | 47 | 17% | cbioportal |
| 29 | MSH6 | Ssm | 8 | 47 | 17% | cbioportal |
Data updated 21 days agoSource updated 2026-01-16