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Neoplasm by Site
CI-CAN-00000003Explore in graph →
Non-malignant20,474 active trials253 approved drugs3,567 evidence items
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Other
CI-CAN-00000003Explore in graph →
Genomics
477 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
1,015 cases with simple somatic mutation data · 1,015 cases total · 2026-01-19 · mapped to Colorectal Adenocarcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 458 |
| 1,015 |
| 45.1% |
| cbioportal |
| 2 | APC | Ssm | 451 | 1,015 | 44.4% | cbioportal |
| 3 | TTN | Ssm | 278 | 1,015 | 27.4% | cbioportal |
| 4 | KRAS | Ssm | 239 | 1,015 | 23.5% | cbioportal |
| 5 | MUC16 | Ssm | 167 | 1,015 | 16.5% | cbioportal |
| 6 | SYNE1 | Ssm | 147 | 1,015 | 14.5% | cbioportal |
| 7 | PIK3CA | Ssm | 130 | 1,015 | 12.8% | cbioportal |
| 8 | OBSCN | Ssm | 126 | 1,015 | 12.4% | cbioportal |
| 9 | FBXW7 | Ssm | 121 | 1,015 | 11.9% | cbioportal |
| 10 | FLG | Ssm | 116 | 1,015 | 11.4% | cbioportal |
| 12 | RYR2 | Ssm | 112 | 1,015 | 11% | cbioportal |
| 11 | FAT4 | Ssm | 112 | 1,015 | 11% | cbioportal |
| 13 | ZFHX4 | Ssm | 108 | 1,015 | 10.6% | cbioportal |
| 14 | LRP1B | Ssm | 105 | 1,015 | 10.3% | cbioportal |
| 15 | RYR1 | Ssm | 101 | 1,015 | 10% | cbioportal |
| 16 | CSMD3 | Ssm | 100 | 1,015 | 9.9% | cbioportal |
| 18 | PCLO | Ssm | 97 | 1,015 | 9.6% | cbioportal |
| 17 | NEB | Ssm | 97 | 1,015 | 9.6% | cbioportal |
| 19 | DNAH11 | Ssm | 96 | 1,015 | 9.5% | cbioportal |
| 20 | USH2A | Ssm | 95 | 1,015 | 9.4% | cbioportal |
| 22 | MUC5B | Ssm | 93 | 1,015 | 9.2% | cbioportal |
| 21 | ABCA13 | Ssm | 93 | 1,015 | 9.2% | cbioportal |
| 23 | DNAH5 | Ssm | 92 | 1,015 | 9.1% | cbioportal |
| 24 | APOB | Ssm | 91 | 1,015 | 9% | cbioportal |
| 25 | CSMD1 | Ssm | 90 | 1,015 | 8.9% | cbioportal |
| 26 | TCF7L2 | Ssm | 90 | 1,015 | 8.9% | cbioportal |
| 27 | FAT3 | Ssm | 87 | 1,015 | 8.6% | cbioportal |
| 28 | RYR3 | Ssm | 83 | 1,015 | 8.2% | cbioportal |
| 30 | HMCN1 | Ssm | 82 | 1,015 | 8.1% | cbioportal |
| 29 | AHNAK2 | Ssm | 82 | 1,015 | 8.1% | cbioportal |
Data updated 21 days agoSource updated 2026-01-19