Gene

ARHGAP35

Rho GTPase activating protein 35

Explore in graph →CI-GENE-00011235HGNC:4591 ENSG00000160007 NCBI 2909 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ARHGAP35 A865_L870delinsV1
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	3	submitted	EID10192 A large scale tumor genome analysis identified p190RhoGAP-encoding gene ARHGAP35 to be frequently mutated in endometrial tumours. Mutant and wild-type HA-tagged ARHGAP35 constructs were created and ex… (full text at CIViC) PMID 27646271 · Binamé et al., 2016 · Open in CIViC	civic
ARHGAP35 Mutation1
(functional)	—UNRESOLVED	Functional	B	Supports Loss Of Function	3	submitted	EID12643 In TCGA endometrial carcinoma (n = 509), ARHGAP35 was somatically mutated in 108 tumors with 152 mutations at 126 positions (20.2%), and pan cancer analysis showed ARHGAP35 mutations in >2% of all tum…

Cohorts

Alteration frequency by cohort (50)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved50 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial Carcinoma (MSK, Molecular Oncology 2024) ucs_msk_2024	Endometrial Carcinoma	Ssm	8	25

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.