CTCF — gene · CancerIndex

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
CTCF K365T1
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	3	accepted	EID10179 Three recurrent CTCF mutations found in endometrial carcinoma were expressed in Ishikawa cells and compared to expression of wild-type CTCF. The K365T mutation did not demonstrate altered localization… (full text at CIViC) PMID 28319062 · Marshall et al., 2017 · Open in CIViC	civic
CTCF P378L1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID9173 Three recurrent CTCF mutations found in endometrial carcinoma were expressed in Ishikawa cells and compared to expression of wild-type CTCF. CTCF P378L showed similar nuclear localization and protein …

Cohorts

Alteration frequency by cohort (137)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved137 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial Carcinoma MSI (MSK, Clin Cancer Res 2022) ucec_ccr_msk_2022	Endometrial Carcinoma	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

CTCF genetic alterations in endometrial carcinoma are pro-tumorigenic.
· Oncogene · 2017 · PMID 28319062 · validated civic_curation pubmed