MACF1

microtubule actin crosslinking factor 1

Explore in graph →CI-GENE-00011788HGNC:13664 ENSG00000127603 NCBI 23499 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MACF1 Fusion1
Aumolertinib	Lung Adenocarcinoma	Predictive	C	Supports Sensitivity Response	2	submitted	EID12365 A 65-year-old female with lung adenocarcinoma underwent NGS testing, revealing an EGFR-MACF1 fusion at the RNA level (mutation abundance: 17%) and EGFR amplification (copy number: 24.15). The fusion i… (full text at CIViC) PMID 38595815 · Wang et al., 2024 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (188)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved188 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cutaneous Squamous Cell Carcinoma (UOW, Front Oncol 2022) cscc_ranson_2022	Skin Squamous Cell Carcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.