Gene

SRSF2

serine and arginine rich splicing factor 2

Explore in graph →CI-GENE-00033789HGNC:10783 ENSG00000161547 NCBI 6427 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SRSF2 MUTATION1
(prognostic)	Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	5	accepted	EID1514 Patients with Acute Myeloid Leukemia showed an synergistic mortality rate with ASXL1 and SRSF2 co-mutations such that individual mutations of either ASXL1 or SRSF2 resulted in ~20% probability of surv… (full text at CIViC) PMID 27276561 · Papaemmanuil et al., 2016 · Open in CIViC	civic
SRSF2 P95H1
CTX-712	Myeloid Neoplasm	Predictive	D	Supports Sensitivity Response	3	accepted	EID11028 Several splicing factors known to drive myeloid neoplasms (including SRSF2) require phosphorylation by CLK family kinases for nuclear translocation. The authors describe development of an inhibiter of…

Cohorts

Alteration frequency by cohort (34)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved34 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Myelodysplastic Syndromes (MDS IWG, IPSSM, NEJM Evidence 2022) mds_iwg_2022	Myelodysplastic Syndrome	Ssm	578	3,323	17.4%

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Genomic Classification and Prognosis in Acute Myeloid Leukemia.
· N Engl J Med · 2016 · PMID 27276561 · validated civic_curation pubmed

SRSF2 P95L2
(oncogenic)	Myelodysplastic SyndromeCURATED_BROADER	Oncogenic	B	Supports Oncogenicity	5	submitted	EID12483 The SRSF2 P95L mutation, located in the RNA recognition motif domain, is a statistically significant hotspot in myeloid malignancies. In vitro studies using HeLa and K562 cells show that P95L disrupts… (full text at CIViC) PMID 26124281 · Komeno et al., 2015 · Open in CIViC	civic
CTX-712	Myeloid Neoplasm	Predictive	D	Supports Sensitivity Response	3	accepted	EID11027 Several splicing factors known to drive myeloid neoplasms (including SRSF2) require phosphorylation by CLK family kinases for nuclear translocation. The authors describe development of an inhibiter o… (full text at CIViC) Open in CIViC	civic