Gene

BCOR

BCL6 corepressor

Explore in graph →CI-GENE-00021727HGNC:20893 ENSG00000183337 NCBI 54880 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (13)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–13 of 13 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
BCOR ITD11
(diagnostic)	Clear Cell Sarcoma of the KidneyALIAS	Diagnostic	B	Supports Positive	5	accepted

Cohorts

Alteration frequency by cohort (200)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved200 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial and Ovarian Cancer (MSK, Nature Medicine 2024) ucec_msk_2024	unmapped	Ssm	12	33

Literature

Linked publications (8)

25 per page, newest first.

pubmedPublishedShowing 1–8 of 8 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney.
· Nat Commun · 2015 · PMID 26573325 · validated civic_curation pubmed
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs.
· Cell · 2016 · PMID 26919435 · validated civic_curation pubmed
Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney.
· Nat Genet · 2015 · PMID 26098867 · validated civic_curation pubmed
Comprehensive mutation profiling of mucinous gastric carcinoma.
· J Pathol · 2016 · PMID 27313181 · validated civic_curation pubmed

BCOR Mutation2
(prognostic)	Myelodysplastic SyndromeCURATED_BROADER	Prognostic	B	Supports Poor Outcome	4	submitted	EID7450 Multivariate analysis on 354 MDS patients including age, International Prognostic Scoring System, transfusion dependency, and mutational status confirmed a significant inferior OS to patients with a B… (full text at CIViC) PMID 24047651 · Damm et al., 2013 · Open in CIViC	civic
〃	Malignant Gastric Neoplasm	Prognostic	B	Supports Better Outcome	3	accepted	EID1681 46 patients with poorly cohesive, signet-cell ring, gastric carcinoma were evaluated for genetic mutations. Overall survival rate of BCOR positive cases were significantly better than BCOR negative c… (full text at CIViC) PMID 27313181 · Rokutan et al., 2016 · Open in CIViC	civic

BCOR Mutation2

(prognostic)

Myelodysplastic SyndromeCURATED_BROADER

Prognostic

Supports Poor Outcome

submitted

EID7450

Multivariate analysis on 354 MDS patients including age, International Prognostic Scoring System, transfusion dependency, and mutational status confirmed a significant inferior OS to patients with a B… (full text at CIViC)

PMID 24047651 · Damm et al., 2013 · Open in CIViC

civic

〃

Malignant Gastric Neoplasm

Prognostic

Supports Better Outcome

accepted

EID1681

46 patients with poorly cohesive, signet-cell ring, gastric carcinoma were evaluated for genetic mutations. Overall survival rate of BCOR positive cases were significantly better than BCOR negative c… (full text at CIViC)

PMID 27313181 · Rokutan et al., 2016 · Open in CIViC

civic