Gene

NOTCH3

notch receptor 3

Explore in graph →CI-GENE-00017013HGNC:7883 ENSG00000074181 NCBI 4854 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NOTCH3 Overexpression2
Tarextumab	Malignant Pancreatic Neoplasm	Predictive	D	Supports Sensitivity Response	3	submitted	EID7001 Notably, the antitumor efficacy of OMP-59R5 in combination with gemcitabine was significantly associated with expression of human Notch3 gene in pancreatic cancer. Tumors that were more sensitive to t… (full text at CIViC) PMID 25934888 · Yen et al., 2015 · Open in CIViC	civic
〃	Rectal CarcinomaALIAS	Predictive	D	Supports Sensitivity Response	3	submitted	EID7002 Finally, treatment of CRC cells with anti-Notch2/3 antibody increased Numb protein while significantly reducing formation of spheroids in both MICOL-14tum cells and primary tumor cultures. This novel … (full text at CIViC) PMID 24525742 ·

Cohorts

Alteration frequency by cohort (176)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved176 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial Carcinoma (MSK, Molecular Oncology 2024) ucs_msk_2024	Endometrial Carcinoma	Ssm	24

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.