Gene

PBRM1

polybromo 1

Explore in graph →CI-GENE-00018976HGNC:30064 ENSG00000163939 NCBI 55193 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (9)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–9 of 9 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PBRM1 Loss-of-function5
Atezolizumab + DurvalumabSubstitutes	Renal Cell CarcinomaCURATED_BROADER	Predictive	B	Supports

Cohorts

Alteration frequency by cohort (167)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved167 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Kidney Renal Clear Cell Carcinoma TCGA-KIRC	Clear Cell Renal Cell Carcinoma

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Adverse outcomes in clear cell renal cell carcinoma with mutations of 3p21 epigenetic regulators BAP1 and SETD2: a report by MSKCC and the KIRC TCGA research network.
· Clin Cancer Res · 2013 · PMID 23620406 · validated civic_curation pubmed
Effects on survival of BAP1 and PBRM1 mutations in sporadic clear-cell renal-cell carcinoma: a retrospective analysis with independent validation.
· Lancet Oncol · 2013 · PMID 23333114 · validated civic_curation pubmed

PBRM1 Mutation4
(prognostic)	Clear Cell Renal Cell Carcinoma	Prognostic	B	Supports N/A	3	accepted	EID420 In renal clear cell carcinoma, patients with PBRM1 mutations did not have a significantly different cancer specific survival. PMID 23620406 · Hakimi et al., 2013 · Open in CIViC	civic
〃	Renal Cell CarcinomaCURATED_BROADER	Prognostic	B	Supports Better Outcome	3	accepted	EID499 In patients with sporatic clear cell renal cell carcinoma, those with mutations in PBRM1 had better overall survival than patients with BAP1 mutations. PMID 23333114 · Kapur et al., 2013 · Open in CIViC	civic
Anti-PD-L1 Monoclonal Antibody + CTLA-4 InhibitorSubstitutes	Clear Cell Renal Cell Carcinoma	Predictive	B	Supports Sensitivity Response	4	submitted	EID7247 Clinical benefit to immune checkpoint blockade was associated with loss-of-function mutations in the PBRM1 gene (P = 0.012), which encodes a subunit of the PBAF switch-sucrose nonfermentable (SWI/SNF)… (full text at CIViC) PMID 29301960 · Miao et al., 2018 · Open in CIViC	civic
Everolimus + SunitinibSequential	Renal Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	submitted	EID5996 This study evaluated the relationship between tumor mutations and treatment outcomes in the RECORD-3 clinical trial. With first-line everolimus, PBRM1 and BAP1 mutations were associated with longer (m… (full text at CIViC) PMID 27751729 · Hsieh et al., 2017 · Open in CIViC	civic