Gene

FOXA1

forkhead box A1

Explore in graph →CI-GENE-00002127HGNC:5021 ENSG00000129514 NCBI 3169 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
FOXA1 Mutation1
Aromatase Inhibitor	Estrogen Receptor-positive Breast CancerUNRESOLVED	Predictive	B	Supports Resistance	2	submitted	EID12910 In a retrospective cohort of metastatic ER+ breast cancer treated with single‑agent aromatase inhibitors (n = 304; FOXA1‑mut n = 17; FOXA1‑WT n = 287). Somatic FOXA1 missense mutations were associated… (full text at CIViC) PMID 32888433 · Arruabarrena-Aristorena et al., 2020 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (102)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved102 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.