Gene
PGR
progesterone receptor
Explore in graph →CI-GENE-00019554HGNC:8910 ENSG00000082175 NCBI 5241 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (5)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
civicProvenance
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 32062536
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ERBB2 Overexpression + ESR1 Expression + PGR ExpressionPGRERBB2ESR11 | ||||||||
| Everolimus/Exemestane Regimen | Malignant Breast Neoplasm | Predictive | B | Supports Sensitivity Response | 2 | submitted | EID12909In the multicenter open-label single-arm non-interventional STEPAUT study of postmenopausal women with HR+, HER2− advanced breast cancer progressing or recurring on/after prior NSAIs (n = 236), the HR… (full text at CIViC) PMID 32062536 · Steger et al., 2020 · Open in CIViC | civic |
| PGR Expression4 | ||||||||
| (prognostic) | Malignant Breast Neoplasm | Prognostic | B | Supports Poor Outcome | 4 | accepted | ||
Cohorts
Alteration frequency by cohort (76)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 38653864
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Endometrial and Ovarian Cancer (MSK, Nature Medicine 2024) ucec_msk_2024 | unmapped | Ssm | 4 | 33 |
Literature
Linked publications (3)
25 per page, newest first.
pubmedProvenance
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)