Gene

HGF

hepatocyte growth factor

Explore in graph →CI-GENE-00004364HGNC:4893 ENSG00000019991 NCBI 3082 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
HGF EXPRESSION1
MET Tyrosine Kinase Inhibitor SGX523	GlioblastomaCURATED_BROADER	Predictive	D	Supports Sensitivity Response	2	accepted	EID1707 Three metastatic glioblastoma cell lines were compared with their parental cell lines with regard to differential gene expression. HGF signalling was among the top pathways identified. Exogenous HFG l… (full text at CIViC) PMID 22203985 · Xie et al., 2012 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (109)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved109 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Small-Cell Lung Cancer (Multi-Institute, Cancer Cell 2017) sclc_cancercell_gardner_2017	Lung Small Cell Carcinoma	Ssm

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Hepatocyte growth factor (HGF) autocrine activation predicts sensitivity to MET inhibition in glioblastoma.
· Proc Natl Acad Sci U S A · 2012 · PMID 22203985 · validated civic_curation pubmed