Gene
SMC3
structural maintenance of chromosomes 3
Explore in graph →CI-GENE-00031422HGNC:2468 ENSG00000108055 NCBI 9126 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (20)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 39386479
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Colorectal Adenocarcinoma (DFCI/Orion, BioRxiv 2024) crc_orion_2024 | unmapped | Ssm | 4 | 74 | 5.4% | 69 | cbioportal |
| Count Me In (CMI): The Metastatic Prostate Cancer (MPC) Project CMI-MPC | Malignant Prostate NeoplasmCURATED_BROADER | Ssm | 3 | 60 | 5% | 51 | gdc |
| Adrenocortical Carcinoma (TCGA GDC, 2025) acc_tcga_gdc | Adrenal Cortical Carcinoma | Ssm | 4 | 90 | 4.4% | 59 | cbioportal |
| Adrenocortical Carcinoma (TCGA, PanCancer Atlas) acc_tcga_pan_can_atlas_2018 | Adrenal Cortical Carcinoma | Ssm | 4 | 91 | 4.4% | 103 |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.