Gene

MAP2K4

mitogen-activated protein kinase kinase 4

Explore in graph →CI-GENE-00011954HGNC:6844 ENSG00000065559 NCBI 6416 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MAP2K4 Amplification1
PLX8725	Uterus LeiomyosarcomaUNRESOLVED	Predictive	D	Supports Sensitivity Response	4	submitted	EID12081 In two MAP2K4-amplified PDX models of uterine leiomyosarcoma, LEY-11 and LEY-16, novel MAP2K4 inhibitor PLX8725 inhibits tumor growth (PDX LEY-11 n=10, p<0.001) (PDX LEY-16 n=8 p=0.0062, n=9 p=0.001),… (full text at CIViC) PMID 36958197 · McNamara et al., 2023 · Open in CIViC	civic
MAP2K4 loss-of-function Mutation + MAP3K1 Loss-of-Function MutationMAP2K4 MAP3K11
Selumetinib	Malignant NeoplasmALIAS	Predictive	D	Supports Sensitivity Response

Cohorts

Alteration frequency by cohort (82)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved82 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.