SMAD3

SMAD family member 3

Explore in graph →CI-GENE-00031378HGNC:6769 ENSG00000166949 NCBI 4088 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SMAD3 R373H1
(functional)	—UNRESOLVED	Functional	D	Supports Loss Of Function	3	submitted	EID10211 In a screen for TGF-beta signaling pathway alterations in colorectal cancer cell lines, the SMAD3 missense mutation R373H was discovered in SNU-769A cells. SMAD3 R373H was expressed in Mv1Lu cells to … (full text at CIViC) PMID 16828225 · Ku et al., 2007 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (48)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved48 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Upper Tract Urothelial Carcinoma PDX (MSK, Nat Commun 2020) utuc_pdx_msk_2019	Renal Pelvis and Ureter Urothelial Carcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.