Gene
HCN1
hyperpolarization activated cyclic nucleotide gated potassium channel 1
Explore in graph →CI-GENE-00004225HGNC:4845 ENSG00000164588 NCBI 348980 Cancer geneApproved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (48)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 22941188
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Small Cell Lung Cancer (CLCGP, Nat Genet 2012) sclc_clcgp | Lung Small Cell Carcinoma | Ssm | 6 | 29 | 20.7% | 30 | cbioportal |
| Lung Squamous Cell Carcinoma (TCGA, Nature 2012) lusc_tcga_pub |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.