Genitourinary System Carcinoma — Genomics

Genitourinary System Carcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

108 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Bladder Cancer (MSK, Eur Urol 2014) blca_mskcc_solit_2014MSK

109 cases with simple somatic mutation data · 109 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Bladder Cancer (MSK, Eur Urol Open Sci 2025) blca_msk_2025MSK

308 cases with simple somatic mutation data · 308 cases total · 2026-01-20 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	190	308	61.7%	cbioportal
2	TP53	Ssm	154	308	50%	cbioportal
3	ARID1A	Ssm	81	308	26.3%	cbioportal
4	KDM6A	Ssm	70	308	22.7%	cbioportal
13	KMT2D	Ssm	24	107	22.4%	cbioportal
17	KMT2C	Ssm	20	107	18.7%	cbioportal
5	FGFR3	Ssm	52	308	16.9%	cbioportal
6	RB1	Ssm	46	308	14.9%	cbioportal
23	ELF3	Ssm	15	107	14%	cbioportal
7	ERBB2	Ssm	42	308	13.6%	cbioportal
8	PIK3CA	Ssm	42	308	13.6%	cbioportal
9	ATM	Ssm	35	308	11.4%	cbioportal
31	STAG2	Ssm	12	107	11.2%	cbioportal
10	TSC1	Ssm	33	308	10.7%	cbioportal
33	CDKN1A	Ssm	11	107	10.3%	cbioportal
34	FAT1	Ssm	11	107	10.3%	cbioportal
11	BRCA2	Ssm	28	308	9.1%	cbioportal
39	H3C7	Ssm	9	107	8.4%	cbioportal
41	MGA	Ssm	9	107	8.4%	cbioportal
40	KMT2A	Ssm	9	107	8.4%	cbioportal
12	SF3B1	Ssm	25	308	8.1%	cbioportal
47	NBN	Ssm	8	107	7.5%	cbioportal
14	BRCA1	Ssm	22	308	7.1%	cbioportal
15	ERBB3	Ssm	21	308	6.8%	cbioportal
53	NCOR1	Ssm	7	107	6.5%	cbioportal
54	ZFHX3	Ssm	7	107	6.5%	cbioportal
51	ANKRD11	Ssm	7	107	6.5%	cbioportal
16	CDKN2A	Ssm	20	308	6.5%	cbioportal
18	NF1	Ssm	20	308	6.5%	cbioportal
19	APC	Ssm	18	308	5.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Bladder Cancer (MSK, J Clin Onco 2013) blca_mskcc_solit_2012MSK

97 cases with simple somatic mutation data · 97 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved11 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	31	97	32%	cbioportal
2	PIK3CA	Ssm	17	97	17.5%	cbioportal
3	FGFR3	Ssm	14	97	14.4%	cbioportal
4	RB1	Ssm	10	97	10.3%	cbioportal
5	TSC1	Ssm	6	97	6.2%	cbioportal
6	KRAS	Ssm	4	97	4.1%	cbioportal
9	CDKN2A	Ssm	2	97	2.1%	cbioportal
7	AKT1	Ssm	2	97	2.1%	cbioportal
8	BRAF	Ssm	2	97	2.1%	cbioportal
10	AKT3	Ssm	1	97	1%	cbioportal
11	PTEN	Ssm	1	97	1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Cancer (MSK, Nat Genet 2016) blca_plasmacytoid_mskcc_2016MSK

34 cases with simple somatic mutation data · 34 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CDH1	Ssm	27	34	79.4%	cbioportal
2	TP53	Ssm	20	34	58.8%	cbioportal
3	TERT	Ssm	12	34	35.3%	cbioportal
4	RB1	Ssm	9	34	26.5%	cbioportal
5	ARID1A	Ssm	8	34	23.5%	cbioportal
6	CDKN1A	Ssm	8	34	23.5%	cbioportal
7	PIK3R1	Ssm	7	34	20.6%	cbioportal
8	KMT2C	Ssm	6	34	17.6%	cbioportal
14	KMT2D	Ssm	5	34	14.7%	cbioportal
9	BAP1	Ssm	5	34	14.7%	cbioportal
10	ERBB2	Ssm	5	34	14.7%	cbioportal
11	ERBB3	Ssm	5	34	14.7%	cbioportal
12	ERCC2	Ssm	5	34	14.7%	cbioportal
13	KMT2A	Ssm	5	34	14.7%	cbioportal
15	PIK3CA	Ssm	5	34	14.7%	cbioportal
18	NOTCH4	Ssm	4	34	11.8%	cbioportal
16	ATR	Ssm	4	34	11.8%	cbioportal
17	EPHB1	Ssm	4	34	11.8%	cbioportal
19	SMARCA4	Ssm	4	34	11.8%	cbioportal
21	EP300	Ssm	3	34	8.8%	cbioportal
26	NOTCH2	Ssm	3	34	8.8%	cbioportal
20	DICER1	Ssm	3	34	8.8%	cbioportal
22	FAT1	Ssm	3	34	8.8%	cbioportal
23	IRS2	Ssm	3	34	8.8%	cbioportal
24	MTOR	Ssm	3	34	8.8%	cbioportal
25	NF1	Ssm	3	34	8.8%	cbioportal
27	NRAS	Ssm	3	34	8.8%	cbioportal
28	PALB2	Ssm	3	34	8.8%	cbioportal
29	PBRM1	Ssm	3	34	8.8%	cbioportal
30	PTEN	Ssm	3	34	8.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Cancer (MSK/TCGA, Eur Urol 2020) blca_msk_tcga_2020MSK/TCGA

474 cases with simple somatic mutation data · 476 cases total · 2026-01-27 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	245	474	51.7%	cbioportal
2	TTN	Ssm	155	474	32.7%	cbioportal
3	KMT2D	Ssm	139	474	29.3%	cbioportal
4	ARID1A	Ssm	127	474	26.8%	cbioportal
5	KDM6A	Ssm	124	474	26.2%	cbioportal
6	PIK3CA	Ssm	103	474	21.7%	cbioportal
7	MUC16	Ssm	101	474	21.3%	cbioportal
8	TERT	Ssm	101	474	21.3%	cbioportal
9	RB1	Ssm	100	474	21.1%	cbioportal
10	KMT2C	Ssm	80	474	16.9%	cbioportal
11	EP300	Ssm	70	474	14.8%	cbioportal
12	ERBB2	Ssm	70	474	14.8%	cbioportal
13	SYNE1	Ssm	66	474	13.9%	cbioportal
14	ERBB3	Ssm	65	474	13.7%	cbioportal
15	RYR2	Ssm	64	474	13.5%	cbioportal
16	FGFR3	Ssm	60	474	12.7%	cbioportal
18	FAT1	Ssm	58	474	12.2%	cbioportal
17	ATM	Ssm	58	474	12.2%	cbioportal
19	BIRC6	Ssm	56	474	11.8%	cbioportal
20	CREBBP	Ssm	56	474	11.8%	cbioportal
22	STAG2	Ssm	55	474	11.6%	cbioportal
21	HMCN1	Ssm	55	474	11.6%	cbioportal
23	MACF1	Ssm	54	474	11.4%	cbioportal
24	FLG	Ssm	53	474	11.2%	cbioportal
25	KMT2A	Ssm	53	474	11.2%	cbioportal
26	FAT4	Ssm	52	474	11%	cbioportal
27	ERCC2	Ssm	50	474	10.5%	cbioportal
28	CSMD3	Ssm	48	474	10.1%	cbioportal
29	ELF3	Ssm	48	474	10.1%	cbioportal
30	BRCA2	Ssm	47	474	9.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-27

Bladder Cancer (TCGA, Cell 2017) blca_tcga_pub_2017TCGA

412 cases with simple somatic mutation data · 413 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	198	412	48.1%	cbioportal
2	TTN	Ssm	198	412	48.1%	cbioportal
4	MUC16	Ssm	117	412	28.4%	cbioportal
3	KMT2D	Ssm	117	412	28.4%	cbioportal
5	KDM6A	Ssm	107	412	26%	cbioportal
6	ARID1A	Ssm	101	412	24.5%	cbioportal
7	PIK3CA	Ssm	91	412	22.1%	cbioportal
8	SYNE1	Ssm	84	412	20.4%	cbioportal
9	RYR2	Ssm	78	412	18.9%	cbioportal
10	KMT2C	Ssm	77	412	18.7%	cbioportal
11	HMCN1	Ssm	76	412	18.4%	cbioportal
12	RB1	Ssm	72	412	17.5%	cbioportal
13	FLG	Ssm	68	412	16.5%	cbioportal
14	MACF1	Ssm	66	412	16%	cbioportal
15	EP300	Ssm	63	412	15.3%	cbioportal
16	FAT4	Ssm	63	412	15.3%	cbioportal
17	FGFR3	Ssm	58	412	14.1%	cbioportal
18	ATM	Ssm	57	412	13.8%	cbioportal
19	CSMD3	Ssm	57	412	13.8%	cbioportal
20	STAG2	Ssm	57	412	13.8%	cbioportal
22	OBSCN	Ssm	56	412	13.6%	cbioportal
21	NEB	Ssm	56	412	13.6%	cbioportal
23	DNAH5	Ssm	54	412	13.1%	cbioportal
24	DNAH11	Ssm	53	412	12.9%	cbioportal
26	SYNE2	Ssm	52	412	12.6%	cbioportal
25	CUBN	Ssm	52	412	12.6%	cbioportal
27	BIRC6	Ssm	51	412	12.4%	cbioportal
28	FAT1	Ssm	51	412	12.4%	cbioportal
30	CREBBP	Ssm	50	412	12.1%	cbioportal
29	AHNAK2	Ssm	50	412	12.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma TCGA-BLCATCGA

412 cases with simple somatic mutation data · 412 cases total · Data Release 46.0 · mapped to Bladder Urothelial Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	294	412	71.4%	gdc
2	TTN	Ssm	281	412	68.2%	gdc
3	CDKN2A	Ssm	269	412	65.3%	gdc
4	CDKN2B	Ssm	267	412	64.8%	gdc
5	AL359922.1	Ssm	264	412	64.1%	gdc
6	CSMD1	Ssm	263	412	63.8%	gdc
7	MTAP	Ssm	261	412	63.3%	gdc
9	CSMD3	Ssm	260	412	63.1%	gdc
8	VPS13B	Ssm	260	412	63.1%	gdc
10	UBR5	Ssm	259	412	62.9%	gdc
11	GRHL2	Ssm	255	412	61.9%	gdc
12	DMRTA1	Ssm	255	412	61.9%	gdc
18	DNAH5	Ssm	253	412	61.4%	gdc
19	TEX15	Ssm	253	412	61.4%	gdc
17	TNFRSF10A	Ssm	253	412	61.4%	gdc
16	ZNF706	Ssm	253	412	61.4%	gdc
15	COL14A1	Ssm	253	412	61.4%	gdc
14	MYOM2	Ssm	253	412	61.4%	gdc
13	PABPC1	Ssm	253	412	61.4%	gdc
20	RIMS2	Ssm	252	412	61.2%	gdc
21	ADRA1A	Ssm	252	412	61.2%	gdc
22	SORBS3	Ssm	251	412	60.9%	gdc
24	CDCA2	Ssm	251	412	60.9%	gdc
25	YWHAZ	Ssm	251	412	60.9%	gdc
26	NEFM	Ssm	251	412	60.9%	gdc
27	FBXO43	Ssm	251	412	60.9%	gdc
28	PKHD1L1	Ssm	251	412	60.9%	gdc
23	RNF19A	Ssm	251	412	60.9%	gdc
30	PRAG1	Ssm	250	412	60.7%	gdc
29	RGS22	Ssm	250	412	60.7%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Bladder Urothelial Carcinoma (BGI, Nat Genet 2013) blca_bgiBGI

99 cases with simple somatic mutation data · 99 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KDM6A	Ssm	32	99	32.3%	cbioportal
2	TP53	Ssm	28	99	28.3%	cbioportal
3	PIK3CA	Ssm	24	99	24.2%	cbioportal
4	ZNF83	Ssm	18	99	18.2%	cbioportal
5	FGFR3	Ssm	16	99	16.2%	cbioportal
8	HRAS	Ssm	15	99	15.2%	cbioportal
6	ARID1A	Ssm	15	99	15.2%	cbioportal
7	CREBBP	Ssm	15	99	15.2%	cbioportal
9	EP300	Ssm	14	99	14.1%	cbioportal
11	STAG2	Ssm	13	99	13.1%	cbioportal
10	RB1	Ssm	13	99	13.1%	cbioportal
12	ZNF233	Ssm	13	99	13.1%	cbioportal
14	ERCC2	Ssm	10	99	10.1%	cbioportal
13	ERBB2	Ssm	10	99	10.1%	cbioportal
15	SYNE2	Ssm	10	99	10.1%	cbioportal
19	XIRP2	Ssm	9	99	9.1%	cbioportal
16	FGFRL1	Ssm	9	99	9.1%	cbioportal
17	HMCN1	Ssm	9	99	9.1%	cbioportal
18	SYNE1	Ssm	9	99	9.1%	cbioportal
20	ZFP36L1	Ssm	9	99	9.1%	cbioportal
21	CSMD3	Ssm	8	99	8.1%	cbioportal
22	KMT2A	Ssm	8	99	8.1%	cbioportal
28	GOLGB1	Ssm	7	99	7.1%	cbioportal
23	ACTB	Ssm	7	99	7.1%	cbioportal
24	ANK3	Ssm	7	99	7.1%	cbioportal
25	AQP7	Ssm	7	99	7.1%	cbioportal
26	DNAH8	Ssm	7	99	7.1%	cbioportal
27	FMN2	Ssm	7	99	7.1%	cbioportal
29	KRAS	Ssm	7	99	7.1%	cbioportal
30	LRP2	Ssm	7	99	7.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (DFCI/MSK, Cancer Discov 2014) blca_dfarber_mskcc_2014DFCI/MSK

50 cases with simple somatic mutation data · 50 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	29	50	58%	cbioportal
2	TTN	Ssm	24	50	48%	cbioportal
3	MUC16	Ssm	19	50	38%	cbioportal
4	ERBB4	Ssm	17	50	34%	cbioportal
5	KMT2D	Ssm	15	50	30%	cbioportal
6	ZAN	Ssm	14	50	28%	cbioportal
7	ARID1A	Ssm	13	50	26%	cbioportal
10	RB1	Ssm	12	50	24%	cbioportal
8	ERBB3	Ssm	12	50	24%	cbioportal
9	KDM6A	Ssm	12	50	24%	cbioportal
11	ZNF721	Ssm	12	50	24%	cbioportal
14	PIK3CA	Ssm	10	50	20%	cbioportal
12	AHNAK2	Ssm	10	50	20%	cbioportal
13	MUC17	Ssm	10	50	20%	cbioportal
16	SYNE1	Ssm	10	50	20%	cbioportal
15	PRG4	Ssm	10	50	20%	cbioportal
22	RPTN	Ssm	9	50	18%	cbioportal
23	SYNE2	Ssm	9	50	18%	cbioportal
21	MAGEC1	Ssm	9	50	18%	cbioportal
20	FAT4	Ssm	9	50	18%	cbioportal
19	ERCC2	Ssm	9	50	18%	cbioportal
18	ANKRD30A	Ssm	9	50	18%	cbioportal
17	AHNAK	Ssm	9	50	18%	cbioportal
30	MUC4	Ssm	8	50	16%	cbioportal
24	ALMS1	Ssm	8	50	16%	cbioportal
25	BIRC6	Ssm	8	50	16%	cbioportal
26	F5	Ssm	8	50	16%	cbioportal
27	FLG	Ssm	8	50	16%	cbioportal
28	KMT2C	Ssm	8	50	16%	cbioportal
29	MDN1	Ssm	8	50	16%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma SWOG S1314 Trial (MSK, JCO Precis Oncol 2024) blca_msk_2024MSK

184 cases with simple somatic mutation data · 184 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	141	184	76.6%	cbioportal
2	TP53	Ssm	116	184	63%	cbioportal
3	KMT2D	Ssm	64	184	34.8%	cbioportal
4	KDM6A	Ssm	55	184	29.9%	cbioportal
5	ARID1A	Ssm	50	184	27.2%	cbioportal
6	RB1	Ssm	48	184	26.1%	cbioportal
7	PIK3CA	Ssm	42	184	22.8%	cbioportal
8	KMT2C	Ssm	35	184	19%	cbioportal
9	ATM	Ssm	31	184	16.8%	cbioportal
10	ELF3	Ssm	29	184	15.8%	cbioportal
11	FAT1	Ssm	29	184	15.8%	cbioportal
12	CREBBP	Ssm	27	184	14.7%	cbioportal
13	ERCC2	Ssm	27	184	14.7%	cbioportal
14	BRCA2	Ssm	26	184	14.1%	cbioportal
15	KMT2A	Ssm	26	184	14.1%	cbioportal
17	FGFR3	Ssm	25	184	13.6%	cbioportal
16	ERBB2	Ssm	25	184	13.6%	cbioportal
19	ERBB3	Ssm	24	184	13%	cbioportal
18	EP300	Ssm	24	184	13%	cbioportal
20	TSC1	Ssm	22	184	12%	cbioportal
21	FBXW7	Ssm	21	184	11.4%	cbioportal
22	CDKN1A	Ssm	20	184	10.9%	cbioportal
24	NF1	Ssm	18	184	9.8%	cbioportal
23	H3C7	Ssm	18	184	9.8%	cbioportal
25	STAG2	Ssm	18	184	9.8%	cbioportal
26	PTPRT	Ssm	17	184	9.2%	cbioportal
29	NSD1	Ssm	16	184	8.7%	cbioportal
28	KMT2B	Ssm	16	184	8.7%	cbioportal
27	CDKN2A	Ssm	16	184	8.7%	cbioportal
30	ARID1B	Ssm	15	184	8.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (TCGA, Firehose Legacy) blca_tcgaTCGA

130 cases with simple somatic mutation data · 413 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	73	130	56.2%	cbioportal
2	TP53	Ssm	64	130	49.2%	cbioportal
3	MUC16	Ssm	43	130	33.1%	cbioportal
4	KMT2D	Ssm	36	130	27.7%	cbioportal
5	ARID1A	Ssm	34	130	26.2%	cbioportal
6	KDM6A	Ssm	31	130	23.8%	cbioportal
7	KMT2C	Ssm	27	130	20.8%	cbioportal
8	PIK3CA	Ssm	26	130	20%	cbioportal
10	SYNE1	Ssm	24	130	18.5%	cbioportal
9	HMCN1	Ssm	24	130	18.5%	cbioportal
11	FLG	Ssm	23	130	17.7%	cbioportal
12	EP300	Ssm	21	130	16.2%	cbioportal
13	RYR2	Ssm	20	130	15.4%	cbioportal
14	MACF1	Ssm	19	130	14.6%	cbioportal
15	PDE4DIP	Ssm	19	130	14.6%	cbioportal
16	PKHD1L1	Ssm	19	130	14.6%	cbioportal
17	ZFHX4	Ssm	19	130	14.6%	cbioportal
18	AHNAK2	Ssm	18	130	13.8%	cbioportal
19	CDKN1A	Ssm	18	130	13.8%	cbioportal
20	KMT2A	Ssm	18	130	13.8%	cbioportal
22	DNAH11	Ssm	17	130	13.1%	cbioportal
21	CREBBP	Ssm	17	130	13.1%	cbioportal
23	FAT4	Ssm	17	130	13.1%	cbioportal
24	LRP1B	Ssm	17	130	13.1%	cbioportal
25	MUC17	Ssm	17	130	13.1%	cbioportal
26	RB1	Ssm	17	130	13.1%	cbioportal
27	SYNE2	Ssm	17	130	13.1%	cbioportal
28	ADGRV1	Ssm	16	130	12.3%	cbioportal
29	ERCC2	Ssm	16	130	12.3%	cbioportal
30	FGFR3	Ssm	16	130	12.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (TCGA GDC, 2025) blca_tcga_gdcTCGA GDC

408 cases with simple somatic mutation data · 413 cases total · 2026-01-19 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	202	408	49.5%	cbioportal
2	TTN	Ssm	176	408	43.1%	cbioportal
3	KMT2D	Ssm	109	408	26.7%	cbioportal
4	KDM6A	Ssm	104	408	25.5%	cbioportal
5	MUC16	Ssm	103	408	25.2%	cbioportal
6	ARID1A	Ssm	100	408	24.5%	cbioportal
7	PIK3CA	Ssm	86	408	21.1%	cbioportal
8	SYNE1	Ssm	80	408	19.6%	cbioportal
9	RB1	Ssm	72	408	17.6%	cbioportal
10	KMT2C	Ssm	69	408	16.9%	cbioportal
11	RYR2	Ssm	69	408	16.9%	cbioportal
12	HMCN1	Ssm	66	408	16.2%	cbioportal
14	FAT4	Ssm	60	408	14.7%	cbioportal
15	MACF1	Ssm	60	408	14.7%	cbioportal
13	EP300	Ssm	60	408	14.7%	cbioportal
16	FLG	Ssm	58	408	14.2%	cbioportal
18	STAG2	Ssm	56	408	13.7%	cbioportal
17	FGFR3	Ssm	56	408	13.7%	cbioportal
19	ELF3	Ssm	55	408	13.5%	cbioportal
20	CSMD3	Ssm	53	408	13%	cbioportal
21	ATM	Ssm	51	408	12.5%	cbioportal
22	OBSCN	Ssm	50	408	12.3%	cbioportal
23	NEB	Ssm	49	408	12%	cbioportal
24	CUBN	Ssm	48	408	11.8%	cbioportal
25	BIRC6	Ssm	47	408	11.5%	cbioportal
27	SYNE2	Ssm	47	408	11.5%	cbioportal
26	DNAH5	Ssm	47	408	11.5%	cbioportal
28	CREBBP	Ssm	46	408	11.3%	cbioportal
29	ERBB2	Ssm	46	408	11.3%	cbioportal
30	XIRP2	Ssm	46	408	11.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Bladder Urothelial Carcinoma (TCGA, Nature 2014) blca_tcga_pubTCGA

130 cases with simple somatic mutation data · 131 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	72	130	55.4%	cbioportal
2	TP53	Ssm	64	130	49.2%	cbioportal
3	MUC16	Ssm	43	130	33.1%	cbioportal
4	KMT2D	Ssm	35	130	26.9%	cbioportal
5	ARID1A	Ssm	33	130	25.4%	cbioportal
6	KDM6A	Ssm	31	130	23.8%	cbioportal
7	KMT2C	Ssm	28	130	21.5%	cbioportal
8	PIK3CA	Ssm	26	130	20%	cbioportal
9	FLG	Ssm	25	130	19.2%	cbioportal
10	HMCN1	Ssm	24	130	18.5%	cbioportal
11	SYNE1	Ssm	24	130	18.5%	cbioportal
13	RYR2	Ssm	20	130	15.4%	cbioportal
12	EP300	Ssm	20	130	15.4%	cbioportal
14	AHNAK2	Ssm	19	130	14.6%	cbioportal
18	ZFHX4	Ssm	19	130	14.6%	cbioportal
17	PKHD1L1	Ssm	19	130	14.6%	cbioportal
16	PDE4DIP	Ssm	19	130	14.6%	cbioportal
15	MACF1	Ssm	19	130	14.6%	cbioportal
21	LRP1B	Ssm	18	130	13.8%	cbioportal
20	KMT2A	Ssm	18	130	13.8%	cbioportal
19	CDKN1A	Ssm	18	130	13.8%	cbioportal
22	SYNE2	Ssm	18	130	13.8%	cbioportal
25	RB1	Ssm	17	130	13.1%	cbioportal
24	MUC17	Ssm	17	130	13.1%	cbioportal
23	LYST	Ssm	17	130	13.1%	cbioportal
26	ADGRV1	Ssm	16	130	12.3%	cbioportal
30	DNAH3	Ssm	16	130	12.3%	cbioportal
29	DNAH11	Ssm	16	130	12.3%	cbioportal
28	CSMD3	Ssm	16	130	12.3%	cbioportal
27	CREBBP	Ssm	16	130	12.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) blca_tcga_pan_can_atlas_2018TCGA

410 cases with simple somatic mutation data · 411 cases total · 2026-08-20 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	202	410	49.3%	cbioportal
2	TTN	Ssm	192	410	46.8%	cbioportal
3	MUC16	Ssm	119	410	29%	cbioportal
4	KMT2D	Ssm	117	410	28.5%	cbioportal
5	KDM6A	Ssm	106	410	25.9%	cbioportal
6	ARID1A	Ssm	105	410	25.6%	cbioportal
7	PIK3CA	Ssm	90	410	22%	cbioportal
8	SYNE1	Ssm	87	410	21.2%	cbioportal
9	KMT2C	Ssm	81	410	19.8%	cbioportal
10	RB1	Ssm	78	410	19%	cbioportal
11	MACF1	Ssm	76	410	18.5%	cbioportal
12	RYR2	Ssm	76	410	18.5%	cbioportal
13	HMCN1	Ssm	75	410	18.3%	cbioportal
14	FLG	Ssm	68	410	16.6%	cbioportal
15	EP300	Ssm	63	410	15.4%	cbioportal
16	FAT4	Ssm	63	410	15.4%	cbioportal
17	FGFR3	Ssm	59	410	14.4%	cbioportal
18	CSMD3	Ssm	58	410	14.1%	cbioportal
19	STAG2	Ssm	57	410	13.9%	cbioportal
20	ATM	Ssm	55	410	13.4%	cbioportal
21	BIRC6	Ssm	54	410	13.2%	cbioportal
23	OBSCN	Ssm	54	410	13.2%	cbioportal
22	ELF3	Ssm	54	410	13.2%	cbioportal
25	NEB	Ssm	53	410	12.9%	cbioportal
24	CUBN	Ssm	53	410	12.9%	cbioportal
26	DNAH11	Ssm	52	410	12.7%	cbioportal
28	SYNE2	Ssm	52	410	12.7%	cbioportal
27	LRP1B	Ssm	52	410	12.7%	cbioportal
30	CREBBP	Ssm	51	410	12.4%	cbioportal
29	AHNAK2	Ssm	51	410	12.4%	cbioportal

Data updated 22 days agoSource updated 2026-08-20

Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma TCGA-CESCTCGA

306 cases with simple somatic mutation data · 307 cases total · Data Release 46.0 · mapped to Cervical Carcinoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	248	306	81%	gdc
2	TNIK	Ssm	228	306	74.5%	gdc
3	SI	Ssm	228	306	74.5%	gdc
5	ZBBX	Ssm	226	306	73.9%	gdc
6	SPATA16	Ssm	226	306	73.9%	gdc
10	FNDC3B	Ssm	226	306	73.9%	gdc
8	SLC7A14	Ssm	226	306	73.9%	gdc
9	BCHE	Ssm	226	306	73.9%	gdc
7	CLDN16	Ssm	226	306	73.9%	gdc
4	TBL1XR1	Ssm	226	306	73.9%	gdc
12	ACTRT3	Ssm	225	306	73.5%	gdc
11	SKIL	Ssm	225	306	73.5%	gdc
18	ABCC5	Ssm	225	306	73.5%	gdc
23	LPP	Ssm	225	306	73.5%	gdc
24	TP63	Ssm	225	306	73.5%	gdc
25	WDR49	Ssm	225	306	73.5%	gdc
26	PEX5L	Ssm	225	306	73.5%	gdc
27	LRRC34	Ssm	225	306	73.5%	gdc
15	MYNN	Ssm	225	306	73.5%	gdc
14	BCL6	Ssm	225	306	73.5%	gdc
13	ATP13A5	Ssm	225	306	73.5%	gdc
16	LRRC31	Ssm	225	306	73.5%	gdc
17	PRKCI	Ssm	225	306	73.5%	gdc
19	SEC62	Ssm	225	306	73.5%	gdc
20	PLD1	Ssm	225	306	73.5%	gdc
21	P3H2	Ssm	225	306	73.5%	gdc
22	CLDN11	Ssm	225	306	73.5%	gdc
28	TMEM207	Ssm	224	306	73.2%	gdc
29	SAMD7	Ssm	224	306	73.2%	gdc
30	PHC3	Ssm	224	306	73.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma (TCGA, Firehose Legacy) cesc_tcgaTCGA

194 cases with simple somatic mutation data · 310 cases total · 2026-01-05 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	62	194	32%	cbioportal
2	PIK3CA	Ssm	53	194	27.3%	cbioportal
3	MUC4	Ssm	37	194	19.1%	cbioportal
4	KMT2C	Ssm	29	194	14.9%	cbioportal
5	MUC16	Ssm	28	194	14.4%	cbioportal
6	ADGRV1	Ssm	26	194	13.4%	cbioportal
7	SYNE1	Ssm	23	194	11.9%	cbioportal
8	KMT2D	Ssm	22	194	11.3%	cbioportal
10	RYR2	Ssm	21	194	10.8%	cbioportal
9	EP300	Ssm	21	194	10.8%	cbioportal
13	SYNE2	Ssm	20	194	10.3%	cbioportal
12	FLG	Ssm	20	194	10.3%	cbioportal
11	DMD	Ssm	20	194	10.3%	cbioportal
14	FBXW7	Ssm	19	194	9.8%	cbioportal
15	USH2A	Ssm	18	194	9.3%	cbioportal
16	OBSCN	Ssm	17	194	8.8%	cbioportal
22	MUC5B	Ssm	16	194	8.2%	cbioportal
19	MACF1	Ssm	16	194	8.2%	cbioportal
20	MDN1	Ssm	16	194	8.2%	cbioportal
17	HLA-A	Ssm	16	194	8.2%	cbioportal
18	HMCN1	Ssm	16	194	8.2%	cbioportal
21	MUC12	Ssm	16	194	8.2%	cbioportal
27	NEB	Ssm	15	194	7.7%	cbioportal
23	ABCA12	Ssm	15	194	7.7%	cbioportal
24	APOB	Ssm	15	194	7.7%	cbioportal
25	ARID1A	Ssm	15	194	7.7%	cbioportal
26	DNAH6	Ssm	15	194	7.7%	cbioportal
28	PCLO	Ssm	15	194	7.7%	cbioportal
29	PTEN	Ssm	15	194	7.7%	cbioportal
30	CREBBP	Ssm	14	194	7.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Cervical Squamous Cell Carcinoma (TCGA GDC, 2025) cesc_tcga_gdcTCGA GDC

289 cases with simple somatic mutation data · 309 cases total · 2026-01-13 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	87	289	30.1%	cbioportal
2	PIK3CA	Ssm	81	289	28%	cbioportal
3	KMT2C	Ssm	54	289	18.7%	cbioportal
4	MUC16	Ssm	49	289	17%	cbioportal
5	KMT2D	Ssm	39	289	13.5%	cbioportal
6	FLG	Ssm	37	289	12.8%	cbioportal
7	EP300	Ssm	36	289	12.5%	cbioportal
8	DMD	Ssm	35	289	12.1%	cbioportal
9	SYNE1	Ssm	35	289	12.1%	cbioportal
10	FBXW7	Ssm	34	289	11.8%	cbioportal
11	LRP1B	Ssm	33	289	11.4%	cbioportal
12	RYR2	Ssm	32	289	11.1%	cbioportal
13	DST	Ssm	31	289	10.7%	cbioportal
14	ADGRV1	Ssm	29	289	10%	cbioportal
15	USH2A	Ssm	29	289	10%	cbioportal
16	HUWE1	Ssm	28	289	9.7%	cbioportal
17	MUC17	Ssm	28	289	9.7%	cbioportal
18	LRP2	Ssm	24	289	8.3%	cbioportal
19	NAV3	Ssm	24	289	8.3%	cbioportal
20	NEB	Ssm	24	289	8.3%	cbioportal
21	SYNE2	Ssm	24	289	8.3%	cbioportal
22	PCLO	Ssm	23	289	8%	cbioportal
23	CREBBP	Ssm	22	289	7.6%	cbioportal
28	MUC5B	Ssm	22	289	7.6%	cbioportal
27	MDN1	Ssm	22	289	7.6%	cbioportal
26	HMCN1	Ssm	22	289	7.6%	cbioportal
25	FAT1	Ssm	22	289	7.6%	cbioportal
24	DNAH2	Ssm	22	289	7.6%	cbioportal
29	CSMD1	Ssm	21	289	7.3%	cbioportal
30	HYDIN	Ssm	21	289	7.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Cervical Squamous Cell Carcinoma (TCGA, PanCancer Atlas) cesc_tcga_pan_can_atlas_2018TCGA

291 cases with simple somatic mutation data · 297 cases total · 2026-06-05 · mapped to Cervical Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	91	291	31.3%	cbioportal
2	PIK3CA	Ssm	83	291	28.5%	cbioportal
3	KMT2C	Ssm	54	291	18.6%	cbioportal
4	MUC4	Ssm	50	291	17.2%	cbioportal
5	MUC16	Ssm	48	291	16.5%	cbioportal
6	KMT2D	Ssm	41	291	14.1%	cbioportal
7	FLG	Ssm	38	291	13.1%	cbioportal
9	SYNE1	Ssm	37	291	12.7%	cbioportal
8	DMD	Ssm	37	291	12.7%	cbioportal
11	FBXW7	Ssm	35	291	12%	cbioportal
12	RYR2	Ssm	35	291	12%	cbioportal
10	EP300	Ssm	35	291	12%	cbioportal
14	USH2A	Ssm	33	291	11.3%	cbioportal
13	LRP1B	Ssm	33	291	11.3%	cbioportal
15	ADGRV1	Ssm	30	291	10.3%	cbioportal
16	MUC17	Ssm	30	291	10.3%	cbioportal
17	HUWE1	Ssm	28	291	9.6%	cbioportal
18	CSMD1	Ssm	27	291	9.3%	cbioportal
19	NEB	Ssm	26	291	8.9%	cbioportal
20	NAV3	Ssm	25	291	8.6%	cbioportal
23	LRP2	Ssm	24	291	8.2%	cbioportal
25	SYNE2	Ssm	24	291	8.2%	cbioportal
21	AHNAK2	Ssm	24	291	8.2%	cbioportal
22	HMCN1	Ssm	24	291	8.2%	cbioportal
24	PCLO	Ssm	24	291	8.2%	cbioportal
30	FAT1	Ssm	23	291	7.9%	cbioportal
28	DST	Ssm	23	291	7.9%	cbioportal
27	DNAH2	Ssm	23	291	7.9%	cbioportal
26	CREBBP	Ssm	23	291	7.9%	cbioportal
29	EYS	Ssm	23	291	7.9%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Chromophobe Renal Cell Carcinoma (TCGA GDC, 2025) chrcc_tcga_gdcTCGA GDC

66 cases with simple somatic mutation data · 66 cases total · 2026-01-13 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	20	66	30.3%	cbioportal
2	PTEN	Ssm	6	66	9.1%	cbioportal
3	TTN	Ssm	4	66	6.1%	cbioportal
6	ICE1	Ssm	3	66	4.5%	cbioportal
5	CSF2RB	Ssm	3	66	4.5%	cbioportal
4	CFAP47	Ssm	3	66	4.5%	cbioportal
7	MUC16	Ssm	3	66	4.5%	cbioportal
8	ZAN	Ssm	3	66	4.5%	cbioportal
25	BSN	Ssm	2	66	3%	cbioportal
26	C3ORF20	Ssm	2	66	3%	cbioportal
27	CACNA1A	Ssm	2	66	3%	cbioportal
28	CACNA1C	Ssm	2	66	3%	cbioportal
29	CDKN1A	Ssm	2	66	3%	cbioportal
19	ATM	Ssm	2	66	3%	cbioportal
21	AXDND1	Ssm	2	66	3%	cbioportal
22	BIRC6	Ssm	2	66	3%	cbioportal
23	BLTP1	Ssm	2	66	3%	cbioportal
16	ARHGEF2	Ssm	2	66	3%	cbioportal
15	ANKRD17	Ssm	2	66	3%	cbioportal
14	AICDA	Ssm	2	66	3%	cbioportal
13	AGBL1	Ssm	2	66	3%	cbioportal
12	AFF3	Ssm	2	66	3%	cbioportal
11	ADGRB1	Ssm	2	66	3%	cbioportal
10	ADAMTSL1	Ssm	2	66	3%	cbioportal
9	ABCE1	Ssm	2	66	3%	cbioportal
36	DIDO1	Ssm	2	66	3%	cbioportal
24	BPTF	Ssm	2	66	3%	cbioportal
17	ATG2A	Ssm	2	66	3%	cbioportal
18	ATG2B	Ssm	2	66	3%	cbioportal
20	ATP10B	Ssm	2	66	3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Clear Cell Renal Cell Carcinoma (DFCI, Science 2019) ccrcc_dfci_2019DFCI

35 cases with simple somatic mutation data · 35 cases total · 2026-01-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	25	35	71.4%	cbioportal
2	PBRM1	Ssm	19	35	54.3%	cbioportal
3	SETD2	Ssm	15	35	42.9%	cbioportal
4	KDM5C	Ssm	7	35	20%	cbioportal
5	MACF1	Ssm	7	35	20%	cbioportal
7	TTN	Ssm	6	35	17.1%	cbioportal
6	CACNA1I	Ssm	6	35	17.1%	cbioportal
8	BAP1	Ssm	5	35	14.3%	cbioportal
17	VPS13B	Ssm	4	35	11.4%	cbioportal
16	USP32	Ssm	4	35	11.4%	cbioportal
15	MTOR	Ssm	4	35	11.4%	cbioportal
14	ITCH	Ssm	4	35	11.4%	cbioportal
13	HDAC9	Ssm	4	35	11.4%	cbioportal
12	DYNC1I1	Ssm	4	35	11.4%	cbioportal
11	DACH2	Ssm	4	35	11.4%	cbioportal
9	AK9	Ssm	4	35	11.4%	cbioportal
10	ATXN7L1	Ssm	4	35	11.4%	cbioportal
21	CHD9	Ssm	3	35	8.6%	cbioportal
20	CD2AP	Ssm	3	35	8.6%	cbioportal
19	CABIN1	Ssm	3	35	8.6%	cbioportal
18	ADAMTS16	Ssm	3	35	8.6%	cbioportal
30	HUWE1	Ssm	3	35	8.6%	cbioportal
29	HMCN1	Ssm	3	35	8.6%	cbioportal
28	HIF1A	Ssm	3	35	8.6%	cbioportal
27	GUCY2C	Ssm	3	35	8.6%	cbioportal
26	FIRRM	Ssm	3	35	8.6%	cbioportal
25	EPB41	Ssm	3	35	8.6%	cbioportal
24	DNAH14	Ssm	3	35	8.6%	cbioportal
23	CTNNA2	Ssm	3	35	8.6%	cbioportal
22	CLCA4	Ssm	3	35	8.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Endometrial cancer HR-positive (MSK, 2024) uec_msk_2024MSK

23 cases with simple somatic mutation data · 24 cases total · 2026-01-20 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	15	24	62.5%	cbioportal
2	ARID1A	Ssm	14	24	58.3%	cbioportal
3	PIK3CA	Ssm	12	24	50%	cbioportal
4	PIK3R1	Ssm	10	24	41.7%	cbioportal
5	CTNNB1	Ssm	9	24	37.5%	cbioportal
6	KRAS	Ssm	6	24	25%	cbioportal
7	BCOR	Ssm	5	24	20.8%	cbioportal
11	ZFHX3	Ssm	4	24	16.7%	cbioportal
8	FGFR2	Ssm	4	24	16.7%	cbioportal
10	PIK3CG	Ssm	4	24	16.7%	cbioportal
9	KMT2D	Ssm	4	24	16.7%	cbioportal
15	KMT2B	Ssm	3	23	13%	cbioportal
17	NOTCH1	Ssm	3	24	12.5%	cbioportal
19	TP53	Ssm	3	24	12.5%	cbioportal
18	SPOP	Ssm	3	24	12.5%	cbioportal
16	MAP3K1	Ssm	3	24	12.5%	cbioportal
14	JAK1	Ssm	3	24	12.5%	cbioportal
13	CTCF	Ssm	3	24	12.5%	cbioportal
12	CCND1	Ssm	3	24	12.5%	cbioportal
120	SMARCE1	Ssm	1	9	11.1%	cbioportal
68	ETAA1	Ssm	1	9	11.1%	cbioportal
108	REST	Ssm	1	9	11.1%	cbioportal
124	SPRTN	Ssm	1	9	11.1%	cbioportal
78	GAB1	Ssm	1	9	11.1%	cbioportal
27	INPPL1	Ssm	2	23	8.7%	cbioportal
39	SLX4	Ssm	2	23	8.7%	cbioportal
21	AKT1	Ssm	2	24	8.3%	cbioportal
32	MTOR	Ssm	2	24	8.3%	cbioportal
22	ANKRD11	Ssm	2	24	8.3%	cbioportal
20	ACVR1	Ssm	2	24	8.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Endometrial Cancer (MSK, 2018) ucec_msk_2018MSK

197 cases with simple somatic mutation data · 197 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	107	197	54.3%	cbioportal
2	PIK3CA	Ssm	80	197	40.6%	cbioportal
3	ARID1A	Ssm	59	197	29.9%	cbioportal
4	PTEN	Ssm	57	197	28.9%	cbioportal
5	PIK3R1	Ssm	46	197	23.4%	cbioportal
6	KRAS	Ssm	42	197	21.3%	cbioportal
7	KMT2D	Ssm	32	197	16.2%	cbioportal
8	CTNNB1	Ssm	30	197	15.2%	cbioportal
9	PPP2R1A	Ssm	30	197	15.2%	cbioportal
10	FBXW7	Ssm	28	197	14.2%	cbioportal
18	ZFHX3	Ssm	16	128	12.5%	cbioportal
11	CTCF	Ssm	23	197	11.7%	cbioportal
12	BCOR	Ssm	20	197	10.2%	cbioportal
14	FAT1	Ssm	19	197	9.6%	cbioportal
15	JAK1	Ssm	19	197	9.6%	cbioportal
13	ATM	Ssm	19	197	9.6%	cbioportal
16	KMT2C	Ssm	17	197	8.6%	cbioportal
17	NOTCH3	Ssm	16	197	8.1%	cbioportal
19	MED12	Ssm	15	197	7.6%	cbioportal
20	MTOR	Ssm	15	197	7.6%	cbioportal
21	SMARCA4	Ssm	15	197	7.6%	cbioportal
22	EP300	Ssm	14	197	7.1%	cbioportal
23	SPEN	Ssm	14	197	7.1%	cbioportal
28	TSC2	Ssm	13	197	6.6%	cbioportal
27	KDM5C	Ssm	13	197	6.6%	cbioportal
26	FGFR2	Ssm	13	197	6.6%	cbioportal
24	AKT1	Ssm	13	197	6.6%	cbioportal
25	ARID1B	Ssm	13	197	6.6%	cbioportal
54	ANKRD11	Ssm	8	128	6.3%	cbioportal
29	ERBB3	Ssm	12	197	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Cancer (MSK, Cancer Discovery 2023) ucec_ancestry_cds_msk_2023MSK

1,882 cases with simple somatic mutation data · 1,882 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	941	1,882	50%	cbioportal
2	TP53	Ssm	850	1,882	45.2%	cbioportal
3	PIK3CA	Ssm	824	1,882	43.8%	cbioportal
4	ARID1A	Ssm	793	1,882	42.1%	cbioportal
5	PIK3R1	Ssm	484	1,882	25.7%	cbioportal
6	KRAS	Ssm	357	1,882	19%	cbioportal
7	CTCF	Ssm	305	1,882	16.2%	cbioportal
8	CTNNB1	Ssm	296	1,882	15.7%	cbioportal
9	FBXW7	Ssm	276	1,882	14.7%	cbioportal
10	ZFHX3	Ssm	237	1,824	13%	cbioportal
13	KMT2B	Ssm	208	1,661	12.5%	cbioportal
11	KMT2D	Ssm	231	1,882	12.3%	cbioportal
12	PPP2R1A	Ssm	226	1,882	12%	cbioportal
15	INPPL1	Ssm	171	1,661	10.3%	cbioportal
14	BCOR	Ssm	184	1,882	9.8%	cbioportal
16	JAK1	Ssm	171	1,882	9.1%	cbioportal
17	RNF43	Ssm	154	1,882	8.2%	cbioportal
18	FGFR2	Ssm	151	1,882	8%	cbioportal
19	ATM	Ssm	139	1,882	7.4%	cbioportal
20	NF1	Ssm	118	1,882	6.3%	cbioportal
21	NSD1	Ssm	103	1,882	5.5%	cbioportal
22	ARID1B	Ssm	102	1,882	5.4%	cbioportal
23	ARID5B	Ssm	96	1,882	5.1%	cbioportal
24	KMT2C	Ssm	96	1,882	5.1%	cbioportal
25	SOX17	Ssm	93	1,882	4.9%	cbioportal
26	CCND1	Ssm	92	1,882	4.9%	cbioportal
28	POLE	Ssm	91	1,882	4.8%	cbioportal
27	FAT1	Ssm	91	1,882	4.8%	cbioportal
29	MED12	Ssm	89	1,882	4.7%	cbioportal
30	RASA1	Ssm	88	1,882	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma cfDNA (MSK, Clin Cancer Res 2022) ucec_ccr_cfdna_msk_2022MSK

44 cases with simple somatic mutation data · 44 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	22	44	50%	cbioportal
3	PTEN	Ssm	21	44	47.7%	cbioportal
2	PIK3CA	Ssm	21	44	47.7%	cbioportal
4	ARID1A	Ssm	15	44	34.1%	cbioportal
5	FBXW7	Ssm	12	44	27.3%	cbioportal
6	KRAS	Ssm	11	44	25%	cbioportal
7	PIK3R1	Ssm	9	44	20.5%	cbioportal
8	CTCF	Ssm	8	44	18.2%	cbioportal
9	KMT2A	Ssm	8	44	18.2%	cbioportal
10	KMT2B	Ssm	8	44	18.2%	cbioportal
11	KMT2D	Ssm	7	44	15.9%	cbioportal
12	JAK1	Ssm	6	44	13.6%	cbioportal
16	NFE2L2	Ssm	5	44	11.4%	cbioportal
13	BCOR	Ssm	5	44	11.4%	cbioportal
14	EP300	Ssm	5	44	11.4%	cbioportal
19	ZFHX3	Ssm	5	44	11.4%	cbioportal
18	RNF43	Ssm	5	44	11.4%	cbioportal
17	POLD1	Ssm	5	44	11.4%	cbioportal
15	INPPL1	Ssm	5	44	11.4%	cbioportal
23	ERF	Ssm	4	44	9.1%	cbioportal
24	NOTCH4	Ssm	4	44	9.1%	cbioportal
20	AR	Ssm	4	44	9.1%	cbioportal
21	ATR	Ssm	4	44	9.1%	cbioportal
22	CREBBP	Ssm	4	44	9.1%	cbioportal
25	PBRM1	Ssm	4	44	9.1%	cbioportal
26	PGR	Ssm	4	44	9.1%	cbioportal
27	PPP2R1A	Ssm	4	44	9.1%	cbioportal
28	RRAS2	Ssm	4	44	9.1%	cbioportal
30	APC	Ssm	3	44	6.8%	cbioportal
29	ANKRD11	Ssm	3	44	6.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma (CPTAC, Cell 2020) ucec_cptac_2020CPTAC

95 cases with simple somatic mutation data · 81 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	75	95	78.9%	cbioportal
2	PIK3CA	Ssm	47	95	49.5%	cbioportal
3	ARID1A	Ssm	43	95	45.3%	cbioportal
4	PIK3R1	Ssm	36	95	37.9%	cbioportal
5	KRAS	Ssm	31	95	32.6%	cbioportal
6	CTNNB1	Ssm	29	95	30.5%	cbioportal
7	CTCF	Ssm	27	95	28.4%	cbioportal
8	KMT2B	Ssm	23	95	24.2%	cbioportal
10	ZFHX3	Ssm	21	95	22.1%	cbioportal
9	TP53	Ssm	21	95	22.1%	cbioportal
11	DOCK3	Ssm	19	95	20%	cbioportal
13	ZFHX4	Ssm	19	95	20%	cbioportal
12	INPPL1	Ssm	19	95	20%	cbioportal
14	FBXW7	Ssm	18	95	18.9%	cbioportal
15	MUC16	Ssm	18	95	18.9%	cbioportal
16	HERC2	Ssm	17	95	17.9%	cbioportal
17	KMT2D	Ssm	17	95	17.9%	cbioportal
25	SYNE1	Ssm	16	95	16.8%	cbioportal
24	SCAF4	Ssm	16	95	16.8%	cbioportal
20	NSD1	Ssm	16	95	16.8%	cbioportal
18	JAK1	Ssm	16	95	16.8%	cbioportal
19	LRTM3	Ssm	16	95	16.8%	cbioportal
21	PCLO	Ssm	16	95	16.8%	cbioportal
22	RBM27	Ssm	16	95	16.8%	cbioportal
23	RPL22	Ssm	16	95	16.8%	cbioportal
29	LMAN1	Ssm	15	95	15.8%	cbioportal
30	OBSCN	Ssm	15	95	15.8%	cbioportal
28	HUWE1	Ssm	15	95	15.8%	cbioportal
27	DNAH17	Ssm	15	95	15.8%	cbioportal
26	AHNAK	Ssm	15	95	15.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma MSI (MSK, Clin Cancer Res 2022) ucec_ccr_msk_2022MSK

181 cases with simple somatic mutation data · 181 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ARID1A	Ssm	160	181	88.4%	cbioportal
2	PTEN	Ssm	156	181	86.2%	cbioportal
3	KMT2D	Ssm	122	181	67.4%	cbioportal
5	KMT2B	Ssm	106	169	62.7%	cbioportal
4	PIK3CA	Ssm	112	181	61.9%	cbioportal
6	CTCF	Ssm	101	181	55.8%	cbioportal
8	INPPL1	Ssm	86	169	50.9%	cbioportal
7	ZFHX3	Ssm	90	180	50%	cbioportal
9	JAK1	Ssm	76	181	42%	cbioportal
10	RNF43	Ssm	76	181	42%	cbioportal
11	ARID1B	Ssm	67	181	37%	cbioportal
12	FAT1	Ssm	62	181	34.3%	cbioportal
13	PIK3R1	Ssm	62	181	34.3%	cbioportal
14	CIC	Ssm	54	181	29.8%	cbioportal
15	NOTCH3	Ssm	53	181	29.3%	cbioportal
16	ANKRD11	Ssm	51	180	28.3%	cbioportal
17	BCOR	Ssm	51	181	28.2%	cbioportal
18	KMT2C	Ssm	51	181	28.2%	cbioportal
19	CREBBP	Ssm	50	181	27.6%	cbioportal
21	SMARCA4	Ssm	48	181	26.5%	cbioportal
20	MSH6	Ssm	48	181	26.5%	cbioportal
23	POLD1	Ssm	47	180	26.1%	cbioportal
22	KRAS	Ssm	47	181	26%	cbioportal
24	FGFR2	Ssm	46	181	25.4%	cbioportal
25	PTPRS	Ssm	46	181	25.4%	cbioportal
26	SPEN	Ssm	46	181	25.4%	cbioportal
27	IRS2	Ssm	45	181	24.9%	cbioportal
28	FBXW7	Ssm	44	181	24.3%	cbioportal
30	CCND1	Ssm	43	181	23.8%	cbioportal
29	ATM	Ssm	43	181	23.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Endometrial Carcinoma (MSK, Molecular Oncology 2024) ucs_msk_2024MSK

69 cases with simple somatic mutation data · 69 cases total · 2026-03-09 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ERBB2	Ssm	69	69	100%	cbioportal
2	ARID1A	Ssm	47	69	68.1%	cbioportal
3	PIK3CA	Ssm	41	69	59.4%	cbioportal
4	PTEN	Ssm	40	69	58%	cbioportal
6	TP53	Ssm	35	69	50.7%	cbioportal
5	KMT2D	Ssm	35	69	50.7%	cbioportal
7	FBXW7	Ssm	27	69	39.1%	cbioportal
15	KMT2B	Ssm	20	57	35.1%	cbioportal
9	NOTCH3	Ssm	24	69	34.8%	cbioportal
8	FAT1	Ssm	24	69	34.8%	cbioportal
10	ZFHX3	Ssm	23	68	33.8%	cbioportal
104	ARHGAP35	Ssm	8	25	32%	cbioportal
11	NOTCH1	Ssm	22	69	31.9%	cbioportal
13	KMT2C	Ssm	21	69	30.4%	cbioportal
12	ERBB3	Ssm	21	69	30.4%	cbioportal
16	POLE	Ssm	20	69	29%	cbioportal
14	ATM	Ssm	20	69	29%	cbioportal
17	ARID1B	Ssm	19	69	27.5%	cbioportal
18	CREBBP	Ssm	19	69	27.5%	cbioportal
19	SMARCA4	Ssm	19	69	27.5%	cbioportal
20	ANKRD11	Ssm	18	68	26.5%	cbioportal
34	INPPL1	Ssm	15	57	26.3%	cbioportal
33	DROSHA	Ssm	15	57	26.3%	cbioportal
21	BCOR	Ssm	18	69	26.1%	cbioportal
24	PIK3R1	Ssm	18	69	26.1%	cbioportal
22	MSH2	Ssm	18	69	26.1%	cbioportal
23	NSD1	Ssm	18	69	26.1%	cbioportal
27	SPEN	Ssm	17	69	24.6%	cbioportal
26	PPP2R1A	Ssm	17	69	24.6%	cbioportal
25	CTCF	Ssm	17	69	24.6%	cbioportal

Data updated 22 days agoSource updated 2026-03-09

Endometrial Carcinoma (TCGA GDC, 2025) ucec_tcga_gdcTCGA GDC

511 cases with simple somatic mutation data · 547 cases total · 2026-01-14 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	334	511	65.4%	cbioportal
2	PIK3CA	Ssm	252	511	49.3%	cbioportal
3	ARID1A	Ssm	235	511	46%	cbioportal
4	TTN	Ssm	194	511	38%	cbioportal
5	TP53	Ssm	190	511	37.2%	cbioportal
6	PIK3R1	Ssm	166	511	32.5%	cbioportal
7	KMT2D	Ssm	140	511	27.4%	cbioportal
8	CTNNB1	Ssm	130	511	25.4%	cbioportal
9	MUC16	Ssm	127	511	24.9%	cbioportal
10	CTCF	Ssm	126	511	24.7%	cbioportal
11	CSMD3	Ssm	121	511	23.7%	cbioportal
12	ZFHX3	Ssm	118	511	23.1%	cbioportal
13	RYR2	Ssm	116	511	22.7%	cbioportal
14	KMT2B	Ssm	114	511	22.3%	cbioportal
15	OBSCN	Ssm	111	511	21.7%	cbioportal
16	DST	Ssm	109	511	21.3%	cbioportal
18	ZFHX4	Ssm	105	511	20.5%	cbioportal
17	MUC5B	Ssm	105	511	20.5%	cbioportal
20	FAT1	Ssm	104	511	20.4%	cbioportal
19	CHD4	Ssm	104	511	20.4%	cbioportal
21	SYNE1	Ssm	103	511	20.2%	cbioportal
23	MACF1	Ssm	102	511	20%	cbioportal
22	DNAH7	Ssm	102	511	20%	cbioportal
24	FAT4	Ssm	101	511	19.8%	cbioportal
25	TAF1	Ssm	101	511	19.8%	cbioportal
26	ARHGAP35	Ssm	98	511	19.2%	cbioportal
27	PCLO	Ssm	98	511	19.2%	cbioportal
28	ATM	Ssm	96	511	18.8%	cbioportal
29	DMD	Ssm	96	511	18.8%	cbioportal
30	DNAH5	Ssm	96	511	18.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Evolution and co-occurrence of PI3K pathway gene mutations in endometrial carcinoma molecular subtypes at the single-cell level ucec_msk_dacruzpaula_2025

11 cases with simple somatic mutation data · 11 cases total · 2026-01-20 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved25 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	10	11	90.9%	cbioportal
2	PIK3R1	Ssm	9	11	81.8%	cbioportal
3	PIK3CA	Ssm	7	11	63.6%	cbioportal
4	CTCF	Ssm	5	11	45.5%	cbioportal
5	FGFR2	Ssm	4	11	36.4%	cbioportal
8	TP53	Ssm	3	11	27.3%	cbioportal
6	ARID1A	Ssm	3	11	27.3%	cbioportal
7	KRAS	Ssm	3	11	27.3%	cbioportal
13	FBXW7	Ssm	2	11	18.2%	cbioportal
14	PDGFRA	Ssm	2	11	18.2%	cbioportal
12	ERBB4	Ssm	2	11	18.2%	cbioportal
11	EGFR	Ssm	2	11	18.2%	cbioportal
10	CTNNB1	Ssm	2	11	18.2%	cbioportal
9	ATM	Ssm	2	11	18.2%	cbioportal
25	VHL	Ssm	1	11	9.1%	cbioportal
24	SMARCB1	Ssm	1	11	9.1%	cbioportal
23	SMAD4	Ssm	1	11	9.1%	cbioportal
22	RB1	Ssm	1	11	9.1%	cbioportal
21	NOTCH1	Ssm	1	11	9.1%	cbioportal
20	MTOR	Ssm	1	11	9.1%	cbioportal
19	MET	Ssm	1	11	9.1%	cbioportal
18	HRAS	Ssm	1	11	9.1%	cbioportal
17	HNF1A	Ssm	1	11	9.1%	cbioportal
16	GNAQ	Ssm	1	11	9.1%	cbioportal
15	BRAF	Ssm	1	11	9.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

High-Grade Serous Ovarian Cancer (MSK, NPJ Genome Med 2021) hgsoc_msk_2021MSK

45 cases with simple somatic mutation data · 45 cases total · 2026-01-07 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	44	45	97.8%	cbioportal
2	BRCA2	Ssm	5	45	11.1%	cbioportal
3	KMT2D	Ssm	4	45	8.9%	cbioportal
9	AGO2	Ssm	2	28	7.1%	cbioportal
7	KMT2C	Ssm	3	45	6.7%	cbioportal
8	NTRK3	Ssm	3	45	6.7%	cbioportal
4	BRCA1	Ssm	3	45	6.7%	cbioportal
5	BRD4	Ssm	3	45	6.7%	cbioportal
6	KDM5A	Ssm	3	45	6.7%	cbioportal
18	MGA	Ssm	2	36	5.6%	cbioportal
21	PDGFRA	Ssm	2	45	4.4%	cbioportal
10	APC	Ssm	2	45	4.4%	cbioportal
24	PPP2R1A	Ssm	2	45	4.4%	cbioportal
23	PIK3R2	Ssm	2	45	4.4%	cbioportal
22	PIK3CA	Ssm	2	45	4.4%	cbioportal
20	NCOR1	Ssm	2	45	4.4%	cbioportal
19	MRE11	Ssm	2	45	4.4%	cbioportal
17	KIT	Ssm	2	45	4.4%	cbioportal
11	AR	Ssm	2	45	4.4%	cbioportal
12	ATRX	Ssm	2	45	4.4%	cbioportal
14	EPHA5	Ssm	2	45	4.4%	cbioportal
15	FLT1	Ssm	2	45	4.4%	cbioportal
16	INPP4B	Ssm	2	45	4.4%	cbioportal
13	CDK12	Ssm	2	45	4.4%	cbioportal
61	INPPL1	Ssm	1	28	3.6%	cbioportal
45	EZH1	Ssm	1	28	3.6%	cbioportal
80	PRKCI	Ssm	1	28	3.6%	cbioportal
93	SESN1	Ssm	1	28	3.6%	cbioportal
90	RRAGC	Ssm	1	28	3.6%	cbioportal
79	PREX2	Ssm	1	28	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

High-Grade Serous Ovarian Cancer (TCGA GDC, 2025) hgsoc_tcga_gdcTCGA GDC

405 cases with simple somatic mutation data · 604 cases total · 2026-01-13 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	369	405	91.1%	cbioportal
2	TTN	Ssm	96	405	23.7%	cbioportal
3	CSMD3	Ssm	36	405	8.9%	cbioportal
4	USH2A	Ssm	31	405	7.7%	cbioportal
5	NF1	Ssm	29	405	7.2%	cbioportal
6	RYR2	Ssm	28	405	6.9%	cbioportal
8	MUC16	Ssm	26	405	6.4%	cbioportal
7	HMCN1	Ssm	26	405	6.4%	cbioportal
9	FAT3	Ssm	23	405	5.7%	cbioportal
10	MACF1	Ssm	22	405	5.4%	cbioportal
11	SI	Ssm	22	405	5.4%	cbioportal
12	AHNAK	Ssm	21	405	5.2%	cbioportal
13	APOB	Ssm	21	405	5.2%	cbioportal
14	FLG2	Ssm	21	405	5.2%	cbioportal
15	MUC17	Ssm	21	405	5.2%	cbioportal
19	LRP1B	Ssm	20	405	4.9%	cbioportal
16	CDK12	Ssm	20	405	4.9%	cbioportal
17	DNAH3	Ssm	20	405	4.9%	cbioportal
18	FLG	Ssm	20	405	4.9%	cbioportal
22	DST	Ssm	19	405	4.7%	cbioportal
21	DNAH5	Ssm	19	405	4.7%	cbioportal
20	BRCA1	Ssm	19	405	4.7%	cbioportal
23	LRP1	Ssm	19	405	4.7%	cbioportal
27	SYNE2	Ssm	18	405	4.4%	cbioportal
26	SYNE1	Ssm	18	405	4.4%	cbioportal
25	FCGBP	Ssm	18	405	4.4%	cbioportal
24	COL6A3	Ssm	18	405	4.4%	cbioportal
28	TG	Ssm	18	405	4.4%	cbioportal
30	DNAH8	Ssm	17	405	4.2%	cbioportal
29	DNAH10	Ssm	17	405	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

HIV+ Tumor Molecular Characterization Project - Cervical Cancer CGCI-HTMCP-CCCGCI

208 cases with simple somatic mutation data · 212 cases total · Data Release 46.0 · mapped to Cervical Carcinoma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	112	208	53.8%	gdc
2	MUC4	Ssm	100	208	48.1%	gdc
3	LRCH3	Ssm	98	208	47.1%	gdc
7	DLG1	Ssm	97	208	46.6%	gdc
6	NCBP2AS2	Ssm	97	208	46.6%	gdc
5	PIGX	Ssm	97	208	46.6%	gdc
4	SENP5	Ssm	97	208	46.6%	gdc
10	CEP19	Ssm	97	208	46.6%	gdc
13	PAK2	Ssm	97	208	46.6%	gdc
11	PIGZ	Ssm	97	208	46.6%	gdc
8	NRROS	Ssm	97	208	46.6%	gdc
9	NCBP2	Ssm	97	208	46.6%	gdc
12	MUC20	Ssm	97	208	46.6%	gdc
25	PCYT1A	Ssm	96	208	46.2%	gdc
27	AC069257.3	Ssm	96	208	46.2%	gdc
28	SMCO1	Ssm	96	208	46.2%	gdc
29	SI	Ssm	96	208	46.2%	gdc
30	FBXO45	Ssm	96	208	46.2%	gdc
31	ZDHHC19	Ssm	96	208	46.2%	gdc
24	MELTF	Ssm	96	208	46.2%	gdc
14	SLC51A	Ssm	96	208	46.2%	gdc
15	RUBCN	Ssm	96	208	46.2%	gdc
16	WDR53	Ssm	96	208	46.2%	gdc
17	RNF168	Ssm	96	208	46.2%	gdc
18	FYTTD1	Ssm	96	208	46.2%	gdc
19	UBXN7	Ssm	96	208	46.2%	gdc
20	TM4SF19-TCTEX1D2	Ssm	96	208	46.2%	gdc
21	TM4SF19	Ssm	96	208	46.2%	gdc
22	BDH1	Ssm	96	208	46.2%	gdc
23	TFRC	Ssm	96	208	46.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Kidney Chromophobe TCGA-KICHTCGA

86 cases with simple somatic mutation data · 113 cases total · Data Release 46.0 · mapped to Chromophobe Renal Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	GPRIN2	Ssm	61	86	70.9%	gdc
9	CROCC	Ssm	59	86	68.6%	gdc
10	ANXA8L1	Ssm	59	86	68.6%	gdc
2	SCNN1D	Ssm	59	86	68.6%	gdc
3	SYT15	Ssm	59	86	68.6%	gdc
8	FAM131C	Ssm	59	86	68.6%	gdc
5	TP53	Ssm	59	86	68.6%	gdc
6	ACAP3	Ssm	59	86	68.6%	gdc
7	GABRD	Ssm	59	86	68.6%	gdc
4	NBPF1	Ssm	59	86	68.6%	gdc
20	DUSP22	Ssm	58	86	67.4%	gdc
21	MIB2	Ssm	58	86	67.4%	gdc
22	TMEM52	Ssm	58	86	67.4%	gdc
23	ATAD3A	Ssm	58	86	67.4%	gdc
24	NADK	Ssm	58	86	67.4%	gdc
25	TAS1R1	Ssm	58	86	67.4%	gdc
26	GNB1	Ssm	58	86	67.4%	gdc
11	INTS11	Ssm	58	86	67.4%	gdc
12	UBE2J2	Ssm	58	86	67.4%	gdc
13	CDK11A	Ssm	58	86	67.4%	gdc
14	TTC34	Ssm	58	86	67.4%	gdc
15	SSU72	Ssm	58	86	67.4%	gdc
16	PUSL1	Ssm	58	86	67.4%	gdc
17	KCNAB2	Ssm	58	86	67.4%	gdc
18	MRPL20	Ssm	58	86	67.4%	gdc
19	TMEM240	Ssm	58	86	67.4%	gdc
30	NECAP2	Ssm	58	86	67.4%	gdc
29	ATAD3C	Ssm	58	86	67.4%	gdc
28	MMP23B	Ssm	58	86	67.4%	gdc
27	DFFA	Ssm	58	86	67.4%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Kidney Chromophobe (TCGA, Cancer Cell 2014) kich_tcga_pubTCGA

65 cases with simple somatic mutation data · 66 cases total · 2026-01-07 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	20	65	30.8%	cbioportal
2	PTEN	Ssm	6	65	9.2%	cbioportal
3	CRACD	Ssm	3	65	4.6%	cbioportal
4	ICE1	Ssm	3	65	4.6%	cbioportal
5	TTN	Ssm	3	65	4.6%	cbioportal
29	ESPL1	Ssm	2	65	3.1%	cbioportal
6	ADAMTS7	Ssm	2	65	3.1%	cbioportal
7	AFF3	Ssm	2	65	3.1%	cbioportal
8	AICDA	Ssm	2	65	3.1%	cbioportal
9	ARHGEF2	Ssm	2	65	3.1%	cbioportal
10	ATM	Ssm	2	65	3.1%	cbioportal
11	BAIAP2L2	Ssm	2	65	3.1%	cbioportal
12	BLTP1	Ssm	2	65	3.1%	cbioportal
13	C3ORF20	Ssm	2	65	3.1%	cbioportal
14	CACNA1A	Ssm	2	65	3.1%	cbioportal
15	CACNA1B	Ssm	2	65	3.1%	cbioportal
16	CASP5	Ssm	2	65	3.1%	cbioportal
17	CDC27	Ssm	2	65	3.1%	cbioportal
18	CDKN1A	Ssm	2	65	3.1%	cbioportal
19	CLCN2	Ssm	2	65	3.1%	cbioportal
20	CSF2RB	Ssm	2	65	3.1%	cbioportal
21	CSMD1	Ssm	2	65	3.1%	cbioportal
22	DDX50	Ssm	2	65	3.1%	cbioportal
23	DIDO1	Ssm	2	65	3.1%	cbioportal
24	DSCAM	Ssm	2	65	3.1%	cbioportal
25	DSPP	Ssm	2	65	3.1%	cbioportal
26	DYNC2H1	Ssm	2	65	3.1%	cbioportal
27	ELAPOR1	Ssm	2	65	3.1%	cbioportal
28	ENTREP3	Ssm	2	65	3.1%	cbioportal
30	FLT4	Ssm	2	65	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Chromophobe (TCGA, Firehose Legacy) kich_tcgaTCGA

66 cases with simple somatic mutation data · 113 cases total · 2026-01-07 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	46	66	69.7%	cbioportal
2	FRG1BP	Ssm	33	66	50%	cbioportal
3	MUC6	Ssm	22	66	33.3%	cbioportal
4	TP53	Ssm	22	66	33.3%	cbioportal
6	MUC2	Ssm	15	66	22.7%	cbioportal
5	MUC16	Ssm	15	66	22.7%	cbioportal
7	FRG1	Ssm	14	66	21.2%	cbioportal
9	NBPF10	Ssm	12	66	18.2%	cbioportal
8	MUC5B	Ssm	12	66	18.2%	cbioportal
10	CDC27	Ssm	11	66	16.7%	cbioportal
12	KMT2C	Ssm	10	66	15.2%	cbioportal
11	AHNAK2	Ssm	10	66	15.2%	cbioportal
15	PABPC3	Ssm	8	66	12.1%	cbioportal
13	DSPP	Ssm	8	66	12.1%	cbioportal
14	PABPC1	Ssm	8	66	12.1%	cbioportal
16	HLA-C	Ssm	7	66	10.6%	cbioportal
28	TAS2R43	Ssm	6	66	9.1%	cbioportal
17	DDX11	Ssm	6	66	9.1%	cbioportal
18	GOLGA6L6	Ssm	6	66	9.1%	cbioportal
19	HLA-A	Ssm	6	66	9.1%	cbioportal
20	MUC17	Ssm	6	66	9.1%	cbioportal
21	MUC21	Ssm	6	66	9.1%	cbioportal
22	PCDHA8	Ssm	6	66	9.1%	cbioportal
23	PRB2	Ssm	6	66	9.1%	cbioportal
24	PRSS3	Ssm	6	66	9.1%	cbioportal
25	PTEN	Ssm	6	66	9.1%	cbioportal
26	RBMXL1	Ssm	6	66	9.1%	cbioportal
27	SLC35G5	Ssm	6	66	9.1%	cbioportal
29	ZNF469	Ssm	6	66	9.1%	cbioportal
30	ADAMTS7	Ssm	5	66	7.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Chromophobe (TCGA, PanCancer Atlas) kich_tcga_pan_can_atlas_2018TCGA

65 cases with simple somatic mutation data · 65 cases total · 2026-06-23 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	21	65	32.3%	cbioportal
2	PTEN	Ssm	6	65	9.2%	cbioportal
3	ZAN	Ssm	5	65	7.7%	cbioportal
5	TTN	Ssm	4	65	6.2%	cbioportal
4	HERC2	Ssm	4	65	6.2%	cbioportal
11	FAT4	Ssm	3	65	4.6%	cbioportal
12	FLT4	Ssm	3	65	4.6%	cbioportal
17	ZFHX4	Ssm	3	65	4.6%	cbioportal
16	PCLO	Ssm	3	65	4.6%	cbioportal
15	MUC16	Ssm	3	65	4.6%	cbioportal
14	KALRN	Ssm	3	65	4.6%	cbioportal
13	ICE1	Ssm	3	65	4.6%	cbioportal
6	ATG2A	Ssm	3	65	4.6%	cbioportal
7	BIRC6	Ssm	3	65	4.6%	cbioportal
8	CFAP47	Ssm	3	65	4.6%	cbioportal
9	CSF2RB	Ssm	3	65	4.6%	cbioportal
10	DNAH1	Ssm	3	65	4.6%	cbioportal
20	ADAMTSL1	Ssm	2	65	3.1%	cbioportal
30	ARHGEF18	Ssm	2	65	3.1%	cbioportal
29	ARFGAP3	Ssm	2	65	3.1%	cbioportal
28	ANKRD17	Ssm	2	65	3.1%	cbioportal
27	ANKHD1	Ssm	2	65	3.1%	cbioportal
26	AMPD2	Ssm	2	65	3.1%	cbioportal
25	AICDA	Ssm	2	65	3.1%	cbioportal
24	AGRN	Ssm	2	65	3.1%	cbioportal
23	AGBL1	Ssm	2	65	3.1%	cbioportal
22	AFF3	Ssm	2	65	3.1%	cbioportal
21	ADGRB1	Ssm	2	65	3.1%	cbioportal
19	ACAP3	Ssm	2	65	3.1%	cbioportal
18	ABCE1	Ssm	2	65	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-06-23

Kidney Renal Clear Cell Carcinoma TCGA-KIRCTCGA

536 cases with simple somatic mutation data · 537 cases total · Data Release 46.0 · mapped to Clear Cell Renal Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	463	536	86.4%	gdc
2	PBRM1	Ssm	456	536	85.1%	gdc
3	BAP1	Ssm	451	536	84.1%	gdc
6	GLB1	Ssm	450	536	84%	gdc
5	COL7A1	Ssm	450	536	84%	gdc
4	PLXNB1	Ssm	450	536	84%	gdc
24	ATRIP	Ssm	449	536	83.8%	gdc
27	TMEM89	Ssm	449	536	83.8%	gdc
26	IP6K2	Ssm	449	536	83.8%	gdc
7	TREX1	Ssm	449	536	83.8%	gdc
8	CDC25A	Ssm	449	536	83.8%	gdc
9	CELSR3	Ssm	449	536	83.8%	gdc
10	PRKAR2A	Ssm	449	536	83.8%	gdc
11	UQCRC1	Ssm	449	536	83.8%	gdc
12	PTH1R	Ssm	449	536	83.8%	gdc
13	SLC26A6	Ssm	449	536	83.8%	gdc
14	SETD2	Ssm	449	536	83.8%	gdc
15	UCN2	Ssm	449	536	83.8%	gdc
16	SHISA5	Ssm	449	536	83.8%	gdc
17	CCDC51	Ssm	449	536	83.8%	gdc
18	PFKFB4	Ssm	449	536	83.8%	gdc
19	FBXW12	Ssm	449	536	83.8%	gdc
20	SCN5A	Ssm	449	536	83.8%	gdc
21	NCKIPSD	Ssm	449	536	83.8%	gdc
22	HHATL	Ssm	449	536	83.8%	gdc
23	VIPR1	Ssm	449	536	83.8%	gdc
25	TMA7	Ssm	449	536	83.8%	gdc
30	DCAF1	Ssm	448	536	83.6%	gdc
28	SLC25A20	Ssm	448	536	83.6%	gdc
29	LAMB2	Ssm	448	536	83.6%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Kidney Renal Clear Cell Carcinoma (BGI, Nat Genet 2012) kirc_bgiBGI

98 cases with simple somatic mutation data · 98 cases total · 2026-01-07 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	25	98	25.5%	cbioportal
2	KDM5C	Ssm	9	98	9.2%	cbioportal
5	SYNE2	Ssm	7	98	7.1%	cbioportal
4	LRP1B	Ssm	7	98	7.1%	cbioportal
3	BAP1	Ssm	7	98	7.1%	cbioportal
6	TP53	Ssm	6	98	6.1%	cbioportal
9	CSMD3	Ssm	5	98	5.1%	cbioportal
8	AKAP13	Ssm	5	98	5.1%	cbioportal
7	AHNAK	Ssm	5	98	5.1%	cbioportal
11	SPTBN4	Ssm	5	98	5.1%	cbioportal
10	RYR1	Ssm	5	98	5.1%	cbioportal
14	NAV3	Ssm	4	98	4.1%	cbioportal
12	CARD11	Ssm	4	98	4.1%	cbioportal
16	ZNF804A	Ssm	4	98	4.1%	cbioportal
15	SETD2	Ssm	4	98	4.1%	cbioportal
13	FAM111B	Ssm	4	98	4.1%	cbioportal
22	MTOR	Ssm	3	98	3.1%	cbioportal
17	ATRNL1	Ssm	3	98	3.1%	cbioportal
18	CUL7	Ssm	3	98	3.1%	cbioportal
19	FMN2	Ssm	3	98	3.1%	cbioportal
20	KMT2C	Ssm	3	98	3.1%	cbioportal
21	LRRK2	Ssm	3	98	3.1%	cbioportal
23	PZP	Ssm	3	98	3.1%	cbioportal
24	SHANK1	Ssm	3	98	3.1%	cbioportal
25	TSC1	Ssm	3	98	3.1%	cbioportal
30	BTRC	Ssm	2	98	2%	cbioportal
26	ADCY9	Ssm	2	98	2%	cbioportal
27	AFDN	Ssm	2	98	2%	cbioportal
28	AGXT	Ssm	2	98	2%	cbioportal
29	APC	Ssm	2	98	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Renal Clear Cell Carcinoma (IRC, Nat Genet 2014) ccrcc_irc_2014IRC

78 cases with simple somatic mutation data · 79 cases total · 2026-01-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	62	78	79.5%	cbioportal
2	PBRM1	Ssm	29	78	37.2%	cbioportal
3	SETD2	Ssm	21	78	26.9%	cbioportal
4	BAP1	Ssm	19	78	24.4%	cbioportal
5	DOP1A	Ssm	17	78	21.8%	cbioportal
6	UGT2A1	Ssm	15	78	19.2%	cbioportal
7	DAPK1	Ssm	13	78	16.7%	cbioportal
10	MYH8	Ssm	12	78	15.4%	cbioportal
9	CENPF	Ssm	12	78	15.4%	cbioportal
8	ANO5	Ssm	12	78	15.4%	cbioportal
18	UNC80	Ssm	11	78	14.1%	cbioportal
16	OR2A14	Ssm	11	78	14.1%	cbioportal
15	MUC16	Ssm	11	78	14.1%	cbioportal
14	ITGB3	Ssm	11	78	14.1%	cbioportal
13	GLTPD2	Ssm	11	78	14.1%	cbioportal
12	EDC4	Ssm	11	78	14.1%	cbioportal
11	DUSP19	Ssm	11	78	14.1%	cbioportal
17	PPP6R1	Ssm	11	78	14.1%	cbioportal
29	FCAMR	Ssm	10	78	12.8%	cbioportal
21	BCAS2	Ssm	10	78	12.8%	cbioportal
20	ATXN1	Ssm	10	78	12.8%	cbioportal
19	ATP11B	Ssm	10	78	12.8%	cbioportal
23	CCR6	Ssm	10	78	12.8%	cbioportal
24	CLCN2	Ssm	10	78	12.8%	cbioportal
25	CYP4F3	Ssm	10	78	12.8%	cbioportal
26	DDX52	Ssm	10	78	12.8%	cbioportal
27	EIF4G2	Ssm	10	78	12.8%	cbioportal
28	EXT1	Ssm	10	78	12.8%	cbioportal
22	C11ORF68	Ssm	10	78	12.8%	cbioportal
30	GARRE1	Ssm	10	78	12.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Kidney Renal Clear Cell Carcinoma (TCGA, Firehose Legacy) kirc_tcgaTCGA

451 cases with simple somatic mutation data · 538 cases total · 2026-01-07 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	225	451	49.9%	cbioportal
2	PBRM1	Ssm	133	451	29.5%	cbioportal
3	MUC4	Ssm	77	451	17.1%	cbioportal
4	TTN	Ssm	71	451	15.7%	cbioportal
5	MUC16	Ssm	58	451	12.9%	cbioportal
6	SETD2	Ssm	51	451	11.3%	cbioportal
7	BAP1	Ssm	40	451	8.9%	cbioportal
8	MTOR	Ssm	32	451	7.1%	cbioportal
9	FBN2	Ssm	30	451	6.7%	cbioportal
10	XIRP2	Ssm	28	451	6.2%	cbioportal
12	KDM5C	Ssm	27	451	6%	cbioportal
11	DNAH3	Ssm	27	451	6%	cbioportal
13	HMCN1	Ssm	26	451	5.8%	cbioportal
16	TSHZ3	Ssm	25	451	5.5%	cbioportal
14	ARAP3	Ssm	25	451	5.5%	cbioportal
15	ARID1A	Ssm	25	451	5.5%	cbioportal
17	SSH2	Ssm	24	451	5.3%	cbioportal
19	NAV3	Ssm	23	451	5.1%	cbioportal
20	SPEN	Ssm	23	451	5.1%	cbioportal
21	VWF	Ssm	23	451	5.1%	cbioportal
18	AKAP9	Ssm	23	451	5.1%	cbioportal
26	PDZD2	Ssm	22	451	4.9%	cbioportal
25	MAP1B	Ssm	22	451	4.9%	cbioportal
24	GRIN2B	Ssm	22	451	4.9%	cbioportal
23	CD4	Ssm	22	451	4.9%	cbioportal
22	ABCA1	Ssm	22	451	4.9%	cbioportal
28	DCHS1	Ssm	21	451	4.7%	cbioportal
37	SSX3	Ssm	21	451	4.7%	cbioportal
27	ABCA6	Ssm	21	451	4.7%	cbioportal
29	DDB1	Ssm	21	451	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Renal Clear Cell Carcinoma (TCGA, Nature 2013) kirc_tcga_pubTCGA

426 cases with simple somatic mutation data · 446 cases total · 2026-02-19 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	218	426	51.2%	cbioportal
2	PBRM1	Ssm	145	426	34%	cbioportal
3	MUC4	Ssm	90	426	21.1%	cbioportal
4	TTN	Ssm	63	426	14.8%	cbioportal
5	SETD2	Ssm	55	426	12.9%	cbioportal
6	BAP1	Ssm	42	426	9.9%	cbioportal
7	MUC16	Ssm	34	426	8%	cbioportal
8	KDM5C	Ssm	29	426	6.8%	cbioportal
9	MTOR	Ssm	23	426	5.4%	cbioportal
10	PABPC1	Ssm	19	426	4.5%	cbioportal
11	HMCN1	Ssm	18	426	4.2%	cbioportal
12	AHNAK2	Ssm	17	426	4%	cbioportal
15	USH2A	Ssm	17	426	4%	cbioportal
14	PTEN	Ssm	17	426	4%	cbioportal
13	KMT2C	Ssm	17	426	4%	cbioportal
17	MAGEC1	Ssm	16	426	3.8%	cbioportal
16	MACF1	Ssm	16	426	3.8%	cbioportal
21	PCLO	Ssm	15	426	3.5%	cbioportal
20	LRP1B	Ssm	15	426	3.5%	cbioportal
19	DNAH9	Ssm	15	426	3.5%	cbioportal
22	SYNE1	Ssm	15	426	3.5%	cbioportal
18	ADGRV1	Ssm	15	426	3.5%	cbioportal
26	KMT2D	Ssm	14	426	3.3%	cbioportal
24	ATM	Ssm	14	426	3.3%	cbioportal
23	ARID1A	Ssm	14	426	3.3%	cbioportal
25	DST	Ssm	14	426	3.3%	cbioportal
30	MUC2	Ssm	13	426	3.1%	cbioportal
28	FMN2	Ssm	13	426	3.1%	cbioportal
27	FBN2	Ssm	13	426	3.1%	cbioportal
29	MUC17	Ssm	13	426	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Kidney Renal Clear Cell Carcinoma (TCGA, PanCancer Atlas) kirc_tcga_pan_can_atlas_2018TCGA

402 cases with simple somatic mutation data · 512 cases total · 2026-06-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	166	402	41.3%	cbioportal
2	PBRM1	Ssm	145	402	36.1%	cbioportal
3	TTN	Ssm	69	402	17.2%	cbioportal
4	SETD2	Ssm	49	402	12.2%	cbioportal
5	BAP1	Ssm	38	402	9.5%	cbioportal
6	MTOR	Ssm	31	402	7.7%	cbioportal
7	MUC16	Ssm	30	402	7.5%	cbioportal
8	KDM5C	Ssm	20	402	5%	cbioportal
9	DNAH9	Ssm	18	402	4.5%	cbioportal
10	CSMD3	Ssm	17	402	4.2%	cbioportal
11	HMCN1	Ssm	17	402	4.2%	cbioportal
12	FBN2	Ssm	16	402	4%	cbioportal
16	PCLO	Ssm	15	402	3.7%	cbioportal
17	XIRP2	Ssm	15	402	3.7%	cbioportal
15	MACF1	Ssm	15	402	3.7%	cbioportal
14	LRP2	Ssm	15	402	3.7%	cbioportal
13	KMT2C	Ssm	15	402	3.7%	cbioportal
21	FLG	Ssm	14	402	3.5%	cbioportal
22	SPEN	Ssm	14	402	3.5%	cbioportal
19	ARID1A	Ssm	14	402	3.5%	cbioportal
20	DST	Ssm	14	402	3.5%	cbioportal
18	AHNAK2	Ssm	14	402	3.5%	cbioportal
26	LRP1B	Ssm	13	402	3.2%	cbioportal
27	MUC17	Ssm	13	402	3.2%	cbioportal
28	NEB	Ssm	13	402	3.2%	cbioportal
29	PKHD1L1	Ssm	13	402	3.2%	cbioportal
30	USH2A	Ssm	13	402	3.2%	cbioportal
23	ABCA13	Ssm	13	402	3.2%	cbioportal
24	ATM	Ssm	13	402	3.2%	cbioportal
25	DNAH2	Ssm	13	402	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Kidney Renal Papillary Cell Carcinoma TCGA-KIRPTCGA

291 cases with simple somatic mutation data · 291 cases total · Data Release 46.0 · mapped to Papillary Renal Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
3	MED13	Ssm	187	291	64.3%	gdc
2	MRC2	Ssm	187	291	64.3%	gdc
1	HELZ	Ssm	187	291	64.3%	gdc
4	RNF213	Ssm	187	291	64.3%	gdc
9	UBE2O	Ssm	186	291	63.9%	gdc
7	ACE	Ssm	186	291	63.9%	gdc
8	CLTC	Ssm	186	291	63.9%	gdc
6	TEX2	Ssm	186	291	63.9%	gdc
5	CCDC57	Ssm	186	291	63.9%	gdc
12	USP32	Ssm	186	291	63.9%	gdc
11	BPTF	Ssm	186	291	63.9%	gdc
10	KCNH6	Ssm	186	291	63.9%	gdc
28	DCAF7	Ssm	185	291	63.6%	gdc
29	PPM1D	Ssm	185	291	63.6%	gdc
30	TBX4	Ssm	185	291	63.6%	gdc
27	TMC6	Ssm	185	291	63.6%	gdc
26	NOL11	Ssm	185	291	63.6%	gdc
25	AC127029.3	Ssm	185	291	63.6%	gdc
24	NPTX1	Ssm	185	291	63.6%	gdc
23	KCNJ16	Ssm	185	291	63.6%	gdc
22	KIF19	Ssm	185	291	63.6%	gdc
21	TNRC6C	Ssm	185	291	63.6%	gdc
20	UNC13D	Ssm	185	291	63.6%	gdc
19	GNA13	Ssm	185	291	63.6%	gdc
18	RNF157	Ssm	185	291	63.6%	gdc
17	TBCD	Ssm	185	291	63.6%	gdc
16	POLG2	Ssm	185	291	63.6%	gdc
15	QRICH2	Ssm	185	291	63.6%	gdc
14	LRRC37A3	Ssm	185	291	63.6%	gdc
13	EFCAB3	Ssm	185	291	63.6%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Kidney Renal Papillary Cell Carcinoma (TCGA, Firehose Legacy) kirp_tcgaTCGA

282 cases with simple somatic mutation data · 293 cases total · 2026-01-07 · mapped to Papillary Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	35	282	12.4%	cbioportal
2	MUC16	Ssm	24	282	8.5%	cbioportal
3	MET	Ssm	21	282	7.4%	cbioportal
4	KMT2C	Ssm	18	282	6.4%	cbioportal
7	SETD2	Ssm	16	282	5.7%	cbioportal
5	BLTP1	Ssm	16	282	5.7%	cbioportal
6	KIF1A	Ssm	16	282	5.7%	cbioportal
8	MUC4	Ssm	15	282	5.3%	cbioportal
10	KMT2D	Ssm	14	282	5%	cbioportal
9	BAP1	Ssm	14	282	5%	cbioportal
13	PKHD1	Ssm	13	282	4.6%	cbioportal
12	OBSCN	Ssm	13	282	4.6%	cbioportal
11	AR	Ssm	13	282	4.6%	cbioportal
17	NEFH	Ssm	12	282	4.3%	cbioportal
18	PCLO	Ssm	12	282	4.3%	cbioportal
15	DNAH8	Ssm	12	282	4.3%	cbioportal
19	WDFY3	Ssm	12	282	4.3%	cbioportal
14	CUBN	Ssm	12	282	4.3%	cbioportal
16	FAT1	Ssm	12	282	4.3%	cbioportal
23	PCF11	Ssm	11	282	3.9%	cbioportal
20	LRP2	Ssm	11	282	3.9%	cbioportal
24	SYNE1	Ssm	11	282	3.9%	cbioportal
22	PBRM1	Ssm	11	282	3.9%	cbioportal
21	MUC2	Ssm	11	282	3.9%	cbioportal
26	HELZ2	Ssm	10	282	3.5%	cbioportal
25	CUL3	Ssm	10	282	3.5%	cbioportal
29	SMARCA4	Ssm	10	282	3.5%	cbioportal
28	NF2	Ssm	10	282	3.5%	cbioportal
27	KDM6A	Ssm	10	282	3.5%	cbioportal
31	ANK3	Ssm	9	282	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Renal Papillary Cell Carcinoma (TCGA, PanCancer Atlas) kirp_tcga_pan_can_atlas_2018TCGA

276 cases with simple somatic mutation data · 283 cases total · 2026-06-05 · mapped to Papillary Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	51	276	18.5%	cbioportal
2	MUC16	Ssm	27	276	9.8%	cbioportal
3	MET	Ssm	22	276	8%	cbioportal
4	BLTP1	Ssm	19	276	6.9%	cbioportal
5	KMT2C	Ssm	19	276	6.9%	cbioportal
7	OBSCN	Ssm	18	276	6.5%	cbioportal
6	KMT2D	Ssm	18	276	6.5%	cbioportal
8	PKHD1	Ssm	18	276	6.5%	cbioportal
10	SETD2	Ssm	17	276	6.2%	cbioportal
9	MACF1	Ssm	17	276	6.2%	cbioportal
11	FAT1	Ssm	16	276	5.8%	cbioportal
12	USH2A	Ssm	15	276	5.4%	cbioportal
15	WDFY3	Ssm	14	276	5.1%	cbioportal
14	DNAH8	Ssm	14	276	5.1%	cbioportal
13	BAP1	Ssm	14	276	5.1%	cbioportal
17	DNAH1	Ssm	13	276	4.7%	cbioportal
18	HERC2	Ssm	13	276	4.7%	cbioportal
19	HUWE1	Ssm	13	276	4.7%	cbioportal
20	SRRM2	Ssm	13	276	4.7%	cbioportal
21	SYNE1	Ssm	13	276	4.7%	cbioportal
22	UBR4	Ssm	13	276	4.7%	cbioportal
16	CUBN	Ssm	13	276	4.7%	cbioportal
29	PBRM1	Ssm	12	276	4.3%	cbioportal
23	ARID1A	Ssm	12	276	4.3%	cbioportal
24	BIRC6	Ssm	12	276	4.3%	cbioportal
25	CENPF	Ssm	12	276	4.3%	cbioportal
26	DST	Ssm	12	276	4.3%	cbioportal
27	MDN1	Ssm	12	276	4.3%	cbioportal
28	NEB	Ssm	12	276	4.3%	cbioportal
30	SYNE2	Ssm	12	276	4.3%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Low-Grade Serous Ovarian Cancer (MSK, Clin Cancer Res 2022) lgsoc_mapk_msk_2022MSK

119 cases with simple somatic mutation data · 119 cases total · 2026-01-16 · mapped to Low-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	38	119	31.9%	cbioportal
2	NRAS	Ssm	13	119	10.9%	cbioportal
4	EIF1AX	Ssm	11	119	9.2%	cbioportal
3	BRAF	Ssm	11	119	9.2%	cbioportal
5	KMT2D	Ssm	5	119	4.2%	cbioportal
6	ERBB2	Ssm	4	119	3.4%	cbioportal
7	ANKRD11	Ssm	3	111	2.7%	cbioportal
8	ARID1B	Ssm	3	119	2.5%	cbioportal
19	RB1	Ssm	2	119	1.7%	cbioportal
11	CTCF	Ssm	2	119	1.7%	cbioportal
10	BARD1	Ssm	2	119	1.7%	cbioportal
9	ATRX	Ssm	2	119	1.7%	cbioportal
12	KMT2A	Ssm	2	119	1.7%	cbioportal
13	KMT2C	Ssm	2	119	1.7%	cbioportal
14	MAP3K1	Ssm	2	119	1.7%	cbioportal
18	PTPRS	Ssm	2	119	1.7%	cbioportal
17	NF2	Ssm	2	119	1.7%	cbioportal
15	MET	Ssm	2	119	1.7%	cbioportal
24	TP53	Ssm	2	119	1.7%	cbioportal
23	TERT	Ssm	2	119	1.7%	cbioportal
22	TBX3	Ssm	2	119	1.7%	cbioportal
21	RUNX1	Ssm	2	119	1.7%	cbioportal
20	ROS1	Ssm	2	119	1.7%	cbioportal
16	NF1	Ssm	2	119	1.7%	cbioportal
52	ERF	Ssm	1	88	1.1%	cbioportal
71	MSH3	Ssm	1	88	1.1%	cbioportal
36	CARM1	Ssm	1	88	1.1%	cbioportal
48	EPAS1	Ssm	1	88	1.1%	cbioportal
88	RTEL1	Ssm	1	88	1.1%	cbioportal
46	ELOC	Ssm	1	111	0.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic Bladder Urothelial Carcinoma (IMvigor210 Phase II Trial, ESMO Open. 2024) - iAtlas Harmonized blca_iatlas_imvigor210_2017

242 cases with simple somatic mutation data · 347 cases total · 2026-02-11 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	128	242	52.9%	cbioportal
2	TP53	Ssm	123	242	50.8%	cbioportal
3	MUC16	Ssm	80	242	33.1%	cbioportal
4	KMT2D	Ssm	70	242	28.9%	cbioportal
5	ARID1A	Ssm	64	242	26.4%	cbioportal
6	OBSCN	Ssm	61	242	25.2%	cbioportal
7	SYNE1	Ssm	55	242	22.7%	cbioportal
8	MACF1	Ssm	54	242	22.3%	cbioportal
9	KDM6A	Ssm	52	242	21.5%	cbioportal
11	PIK3CA	Ssm	46	242	19%	cbioportal
10	FAT1	Ssm	46	242	19%	cbioportal
12	RYR3	Ssm	45	242	18.6%	cbioportal
13	LRTM3	Ssm	44	242	18.2%	cbioportal
14	LRP1B	Ssm	43	242	17.8%	cbioportal
15	RNF213	Ssm	43	242	17.8%	cbioportal
16	FGFR3	Ssm	42	242	17.4%	cbioportal
17	ADGRV1	Ssm	41	242	16.9%	cbioportal
18	CREBBP	Ssm	40	242	16.5%	cbioportal
19	DST	Ssm	40	242	16.5%	cbioportal
20	FLG	Ssm	40	242	16.5%	cbioportal
21	PKHD1L1	Ssm	40	242	16.5%	cbioportal
27	PCLO	Ssm	39	242	16.1%	cbioportal
22	AHNAK2	Ssm	39	242	16.1%	cbioportal
23	ELF3	Ssm	39	242	16.1%	cbioportal
24	FAT4	Ssm	39	242	16.1%	cbioportal
25	HMCN1	Ssm	39	242	16.1%	cbioportal
26	MUC5AC	Ssm	39	242	16.1%	cbioportal
29	MUC3A	Ssm	38	242	15.7%	cbioportal
28	KMT2C	Ssm	38	242	15.7%	cbioportal
30	RYR2	Ssm	38	242	15.7%	cbioportal

Data updated 22 days agoSource updated 2026-02-11

Metastatic castration-sensitive prostate cancer (MSK, Clin Cancer Res 2020) prad_mcspc_mskcc_2020MSK

424 cases with simple somatic mutation data · 424 cases total · 2026-04-07 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	129	424	30.4%	cbioportal
2	SPOP	Ssm	53	424	12.5%	cbioportal
3	FOXA1	Ssm	50	424	11.8%	cbioportal
4	PTEN	Ssm	46	424	10.8%	cbioportal
5	APC	Ssm	36	424	8.5%	cbioportal
6	KMT2C	Ssm	34	424	8%	cbioportal
7	KMT2D	Ssm	30	424	7.1%	cbioportal
8	ZFHX3	Ssm	25	387	6.5%	cbioportal
11	PIK3CA	Ssm	24	424	5.7%	cbioportal
9	ATM	Ssm	24	424	5.7%	cbioportal
10	CDK12	Ssm	24	424	5.7%	cbioportal
12	CTNNB1	Ssm	23	424	5.4%	cbioportal
13	BRCA2	Ssm	19	424	4.5%	cbioportal
15	MGA	Ssm	14	387	3.6%	cbioportal
14	SPEN	Ssm	15	424	3.5%	cbioportal
16	NCOR1	Ssm	13	424	3.1%	cbioportal
57	TP53BP1	Ssm	7	233	3%	cbioportal
18	CREBBP	Ssm	12	424	2.8%	cbioportal
19	JAK1	Ssm	12	424	2.8%	cbioportal
17	BRAF	Ssm	12	424	2.8%	cbioportal
21	GRIN2A	Ssm	11	424	2.6%	cbioportal
20	FAT1	Ssm	11	424	2.6%	cbioportal
22	PTPRT	Ssm	11	424	2.6%	cbioportal
26	ASXL2	Ssm	10	424	2.4%	cbioportal
29	NOTCH1	Ssm	10	424	2.4%	cbioportal
25	ASXL1	Ssm	10	424	2.4%	cbioportal
24	ARID1B	Ssm	10	424	2.4%	cbioportal
23	ARID1A	Ssm	10	424	2.4%	cbioportal
27	KMT2A	Ssm	10	424	2.4%	cbioportal
28	NF1	Ssm	10	424	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Metastatic Prostate Adenocarcinoma (MCTP, Nature 2012) prad_michMCTP

61 cases with simple somatic mutation data · 121 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	25	61	41%	cbioportal
2	TTN	Ssm	8	61	13.1%	cbioportal
3	ZFHX3	Ssm	8	61	13.1%	cbioportal
4	ABCA13	Ssm	7	61	11.5%	cbioportal
5	RYR3	Ssm	7	61	11.5%	cbioportal
6	APC	Ssm	6	61	9.8%	cbioportal
7	DNAH11	Ssm	6	61	9.8%	cbioportal
8	KMT2D	Ssm	6	61	9.8%	cbioportal
9	MUC16	Ssm	6	61	9.8%	cbioportal
10	PTEN	Ssm	6	61	9.8%	cbioportal
11	RB1	Ssm	6	61	9.8%	cbioportal
12	AR	Ssm	5	61	8.2%	cbioportal
13	CSMD1	Ssm	5	61	8.2%	cbioportal
14	USH2A	Ssm	5	61	8.2%	cbioportal
25	LPAR1	Ssm	4	61	6.6%	cbioportal
15	ASXL2	Ssm	4	61	6.6%	cbioportal
16	ATM	Ssm	4	61	6.6%	cbioportal
17	CDC42EP1	Ssm	4	61	6.6%	cbioportal
18	COL6A3	Ssm	4	61	6.6%	cbioportal
19	DGKB	Ssm	4	61	6.6%	cbioportal
20	FAT4	Ssm	4	61	6.6%	cbioportal
21	FREM2	Ssm	4	61	6.6%	cbioportal
22	GRIA1	Ssm	4	61	6.6%	cbioportal
23	HSPG2	Ssm	4	61	6.6%	cbioportal
24	JARID2	Ssm	4	61	6.6%	cbioportal
26	MAGI3	Ssm	4	61	6.6%	cbioportal
27	NAALADL2	Ssm	4	61	6.6%	cbioportal
28	NEB	Ssm	4	61	6.6%	cbioportal
29	PLEC	Ssm	4	61	6.6%	cbioportal
30	RYR1	Ssm	4	61	6.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Metastatic Prostate Adenocarcinoma (SU2C/PCF Dream Team, PNAS 2019) prad_su2c_2019SU2C/PCF Dream Team

444 cases with simple somatic mutation data · 444 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	163	444	36.7%	cbioportal
2	TTN	Ssm	88	444	19.8%	cbioportal
3	MUC16	Ssm	67	444	15.1%	cbioportal
4	AR	Ssm	61	444	13.7%	cbioportal
5	SYNE1	Ssm	49	444	11%	cbioportal
6	CSMD3	Ssm	43	444	9.7%	cbioportal
7	FOXA1	Ssm	41	444	9.2%	cbioportal
8	KMT2C	Ssm	40	444	9%	cbioportal
9	BRCA2	Ssm	37	444	8.3%	cbioportal
10	KMT2D	Ssm	37	444	8.3%	cbioportal
11	AHNAK2	Ssm	35	444	7.9%	cbioportal
12	HMCN1	Ssm	32	444	7.2%	cbioportal
13	APC	Ssm	31	444	7%	cbioportal
14	USH2A	Ssm	31	444	7%	cbioportal
15	CACNA1E	Ssm	29	444	6.5%	cbioportal
16	OBSCN	Ssm	29	444	6.5%	cbioportal
18	PLEC	Ssm	28	444	6.3%	cbioportal
17	LRP1B	Ssm	28	444	6.3%	cbioportal
20	RYR1	Ssm	28	444	6.3%	cbioportal
19	PTEN	Ssm	28	444	6.3%	cbioportal
22	DCHS2	Ssm	27	444	6.1%	cbioportal
23	FAT3	Ssm	27	444	6.1%	cbioportal
21	ATM	Ssm	27	444	6.1%	cbioportal
26	RYR3	Ssm	26	444	5.9%	cbioportal
24	CDK12	Ssm	26	444	5.9%	cbioportal
25	MUC4	Ssm	26	444	5.9%	cbioportal
27	ABCA13	Ssm	25	444	5.6%	cbioportal
29	RYR2	Ssm	25	444	5.6%	cbioportal
30	SPOP	Ssm	25	444	5.6%	cbioportal
28	MACF1	Ssm	25	444	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic Prostate Cancer (SU2C/PCF Dream Team, Cell 2015) prad_su2c_2015SU2C/PCF Dream Team

150 cases with simple somatic mutation data · 150 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	60	150	40%	cbioportal
2	TP53	Ssm	58	150	38.7%	cbioportal
3	TTN	Ssm	41	150	27.3%	cbioportal
4	MUC16	Ssm	35	150	23.3%	cbioportal
5	AR	Ssm	27	150	18%	cbioportal
6	KMT2C	Ssm	23	150	15.3%	cbioportal
7	SYNE1	Ssm	21	150	14%	cbioportal
8	KMT2D	Ssm	18	150	12%	cbioportal
9	FOXA1	Ssm	16	150	10.7%	cbioportal
10	MUC2	Ssm	15	150	10%	cbioportal
13	PIEZO1	Ssm	14	150	9.3%	cbioportal
14	USH2A	Ssm	14	150	9.3%	cbioportal
12	FAT4	Ssm	14	150	9.3%	cbioportal
11	CSMD3	Ssm	14	150	9.3%	cbioportal
15	CSMD1	Ssm	13	150	8.7%	cbioportal
16	PLEC	Ssm	13	150	8.7%	cbioportal
19	SPOP	Ssm	12	150	8%	cbioportal
17	APC	Ssm	12	150	8%	cbioportal
18	LRP1B	Ssm	12	150	8%	cbioportal
22	DCHS2	Ssm	11	150	7.3%	cbioportal
24	HMCN1	Ssm	11	150	7.3%	cbioportal
25	MUC5B	Ssm	11	150	7.3%	cbioportal
26	OBSCN	Ssm	11	150	7.3%	cbioportal
27	PKHD1L1	Ssm	11	150	7.3%	cbioportal
28	PREX2	Ssm	11	150	7.3%	cbioportal
29	PTEN	Ssm	11	150	7.3%	cbioportal
30	RYR1	Ssm	11	150	7.3%	cbioportal
21	CNTNAP5	Ssm	11	150	7.3%	cbioportal
20	ABCA13	Ssm	11	150	7.3%	cbioportal
23	DNAH3	Ssm	11	150	7.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic Renal Clear Cell Carcinoma (Phase 1 Biomarker Trial, Clin Cancer Res. 2016) - iAtlas Harmonized ccrcc_iatlas_choueiri_2016

16 cases with simple somatic mutation data · 16 cases total · 2026-02-16 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SETD2	Ssm	10	16	62.5%	cbioportal
2	VHL	Ssm	8	16	50%	cbioportal
3	PBRM1	Ssm	6	16	37.5%	cbioportal
4	BTG4	Ssm	4	16	25%	cbioportal
5	FBXL13	Ssm	4	16	25%	cbioportal
6	ZFC3H1	Ssm	4	16	25%	cbioportal
22	UBR4	Ssm	3	16	18.8%	cbioportal
7	ARHGAP39	Ssm	3	16	18.8%	cbioportal
8	CENPB	Ssm	3	16	18.8%	cbioportal
9	DMXL2	Ssm	3	16	18.8%	cbioportal
10	FNDC1	Ssm	3	16	18.8%	cbioportal
11	HEATR1	Ssm	3	16	18.8%	cbioportal
12	HUWE1	Ssm	3	16	18.8%	cbioportal
13	LRP2	Ssm	3	16	18.8%	cbioportal
14	MYO10	Ssm	3	16	18.8%	cbioportal
15	PRKDC	Ssm	3	16	18.8%	cbioportal
16	SCUBE2	Ssm	3	16	18.8%	cbioportal
17	SLC9A9	Ssm	3	16	18.8%	cbioportal
18	SPEF2	Ssm	3	16	18.8%	cbioportal
19	SRPK1	Ssm	3	16	18.8%	cbioportal
20	SYNE1	Ssm	3	16	18.8%	cbioportal
21	TTN	Ssm	3	16	18.8%	cbioportal
23	VCPIP1	Ssm	3	16	18.8%	cbioportal
24	WDR47	Ssm	3	16	18.8%	cbioportal
29	ADAR	Ssm	2	16	12.5%	cbioportal
30	AGBL2	Ssm	2	16	12.5%	cbioportal
25	ABCA5	Ssm	2	16	12.5%	cbioportal
26	ABCC2	Ssm	2	16	12.5%	cbioportal
27	ADAMTS20	Ssm	2	16	12.5%	cbioportal
28	ADAMTSL3	Ssm	2	16	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-16

Neuroendocrine Prostate Cancer (Multi-Institute, Nat Med 2016) nepc_wcm_2016Multi-Institute

114 cases with simple somatic mutation data · 114 cases total · 2026-01-08 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	27	114	23.7%	cbioportal
2	TTN	Ssm	21	114	18.4%	cbioportal
3	SPOP	Ssm	13	114	11.4%	cbioportal
4	MUC16	Ssm	11	114	9.6%	cbioportal
5	OBSCN	Ssm	10	114	8.8%	cbioportal
7	HMCN1	Ssm	9	114	7.9%	cbioportal
8	SHANK1	Ssm	9	114	7.9%	cbioportal
9	TMC8	Ssm	9	114	7.9%	cbioportal
10	ZNF208	Ssm	9	114	7.9%	cbioportal
11	ZNF626	Ssm	9	114	7.9%	cbioportal
12	ZNF729	Ssm	9	114	7.9%	cbioportal
6	FOXA1	Ssm	9	114	7.9%	cbioportal
14	DNAH3	Ssm	8	114	7%	cbioportal
15	DYNC1H1	Ssm	8	114	7%	cbioportal
16	FSIP2	Ssm	8	114	7%	cbioportal
17	KMO	Ssm	8	114	7%	cbioportal
18	LTBP1	Ssm	8	114	7%	cbioportal
19	METTL24	Ssm	8	114	7%	cbioportal
20	RB1	Ssm	8	114	7%	cbioportal
21	ZNFX1	Ssm	8	114	7%	cbioportal
13	CPD	Ssm	8	114	7%	cbioportal
24	COL14A1	Ssm	7	114	6.1%	cbioportal
30	SLC44A5	Ssm	7	114	6.1%	cbioportal
29	PIWIL2	Ssm	7	114	6.1%	cbioportal
28	OR9A4	Ssm	7	114	6.1%	cbioportal
27	NR2E1	Ssm	7	114	6.1%	cbioportal
26	NBPF3	Ssm	7	114	6.1%	cbioportal
25	CSMD3	Ssm	7	114	6.1%	cbioportal
23	CHRNA3	Ssm	7	114	6.1%	cbioportal
22	ADRM1	Ssm	7	114	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Nonmuscle Invasive Bladder Cancer (MSK Eur Urol 2017) blca_nmibc_2017

105 cases with simple somatic mutation data · 105 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	77	105	73.3%	cbioportal
2	KDM6A	Ssm	50	105	47.6%	cbioportal
3	FGFR3	Ssm	47	105	44.8%	cbioportal
4	ARID1A	Ssm	30	105	28.6%	cbioportal
5	PIK3CA	Ssm	29	105	27.6%	cbioportal
6	KMT2D	Ssm	25	105	23.8%	cbioportal
9	TP53	Ssm	22	105	21%	cbioportal
7	CREBBP	Ssm	22	105	21%	cbioportal
8	STAG2	Ssm	22	105	21%	cbioportal
10	ERBB2	Ssm	19	105	18.1%	cbioportal
11	ERCC2	Ssm	18	105	17.1%	cbioportal
13	FAT1	Ssm	17	105	16.2%	cbioportal
12	ARID1B	Ssm	17	105	16.2%	cbioportal
14	ATM	Ssm	16	105	15.2%	cbioportal
16	FBXW7	Ssm	15	105	14.3%	cbioportal
15	EP300	Ssm	15	105	14.3%	cbioportal
18	RBM10	Ssm	15	105	14.3%	cbioportal
17	PBRM1	Ssm	15	105	14.3%	cbioportal
19	MGA	Ssm	14	103	13.6%	cbioportal
20	BAP1	Ssm	13	105	12.4%	cbioportal
21	CDKN1A	Ssm	12	105	11.4%	cbioportal
24	NF1	Ssm	12	105	11.4%	cbioportal
22	ERBB3	Ssm	12	105	11.4%	cbioportal
23	KMT2C	Ssm	12	105	11.4%	cbioportal
28	TSC1	Ssm	11	105	10.5%	cbioportal
25	BRCA2	Ssm	11	105	10.5%	cbioportal
27	SPEN	Ssm	11	105	10.5%	cbioportal
26	SMARCA4	Ssm	11	105	10.5%	cbioportal
29	ATR	Ssm	10	105	9.5%	cbioportal
30	NCOR1	Ssm	10	105	9.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Ovarian Serous Cystadenocarcinoma TCGA-OVTCGA

603 cases with simple somatic mutation data · 608 cases total · Data Release 46.0 · mapped to Ovarian Serous Cystadenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	483	603	80.1%	gdc
2	MYC	Ssm	455	603	75.5%	gdc
3	POU5F1B	Ssm	449	603	74.5%	gdc
4	FAM135B	Ssm	449	603	74.5%	gdc
5	ACTRT3	Ssm	447	603	74.1%	gdc
7	ADCY8	Ssm	446	603	74%	gdc
9	PTK2	Ssm	446	603	74%	gdc
10	LRRC34	Ssm	446	603	74%	gdc
6	AGO2	Ssm	446	603	74%	gdc
8	MYNN	Ssm	446	603	74%	gdc
13	LRRC31	Ssm	445	603	73.8%	gdc
16	LRATD2	Ssm	445	603	73.8%	gdc
15	LRRIQ4	Ssm	445	603	73.8%	gdc
11	GSDMC	Ssm	445	603	73.8%	gdc
12	PTP4A3	Ssm	445	603	73.8%	gdc
14	GPR20	Ssm	445	603	73.8%	gdc
23	CHRAC1	Ssm	444	603	73.6%	gdc
24	TG	Ssm	444	603	73.6%	gdc
22	SEC62	Ssm	444	603	73.6%	gdc
21	ASAP1	Ssm	444	603	73.6%	gdc
20	TRIB1	Ssm	444	603	73.6%	gdc
19	AC138647.1	Ssm	444	603	73.6%	gdc
18	SLC45A4	Ssm	444	603	73.6%	gdc
17	SAMD7	Ssm	444	603	73.6%	gdc
30	SCRIB	Ssm	443	603	73.5%	gdc
25	GPR160	Ssm	443	603	73.5%	gdc
26	COL22A1	Ssm	443	603	73.5%	gdc
27	KHDRBS3	Ssm	443	603	73.5%	gdc
28	KCNK9	Ssm	443	603	73.5%	gdc
29	MECOM	Ssm	443	603	73.5%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Ovarian Serous Cystadenocarcinoma (TCGA, Firehose Legacy) ov_tcgaTCGA

316 cases with simple somatic mutation data · 617 cases total · 2026-01-12 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	277	316	87.7%	cbioportal
2	TTN	Ssm	56	316	17.7%	cbioportal
3	USH2A	Ssm	20	316	6.3%	cbioportal
4	FAT3	Ssm	19	316	6%	cbioportal
6	MUC16	Ssm	18	316	5.7%	cbioportal
5	CSMD3	Ssm	18	316	5.7%	cbioportal
7	HMCN1	Ssm	15	316	4.7%	cbioportal
8	LRP2	Ssm	15	316	4.7%	cbioportal
9	NF1	Ssm	14	316	4.4%	cbioportal
10	RYR2	Ssm	14	316	4.4%	cbioportal
11	DNAH5	Ssm	13	316	4.1%	cbioportal
12	LRP1B	Ssm	13	316	4.1%	cbioportal
14	AHNAK2	Ssm	12	316	3.8%	cbioportal
16	COL6A3	Ssm	12	316	3.8%	cbioportal
15	BRCA1	Ssm	12	316	3.8%	cbioportal
13	AHNAK	Ssm	12	316	3.8%	cbioportal
22	HYDIN	Ssm	11	316	3.5%	cbioportal
20	FAT1	Ssm	11	316	3.5%	cbioportal
19	DNAH3	Ssm	11	316	3.5%	cbioportal
18	BRCA2	Ssm	11	316	3.5%	cbioportal
17	APOB	Ssm	11	316	3.5%	cbioportal
23	MUC17	Ssm	11	316	3.5%	cbioportal
24	RYR1	Ssm	11	316	3.5%	cbioportal
21	HUWE1	Ssm	11	316	3.5%	cbioportal
28	TENM1	Ssm	10	316	3.2%	cbioportal
25	LRRK2	Ssm	10	316	3.2%	cbioportal
27	SI	Ssm	10	316	3.2%	cbioportal
26	PKHD1	Ssm	10	316	3.2%	cbioportal
29	CDK12	Ssm	9	316	2.8%	cbioportal
30	COL22A1	Ssm	9	316	2.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Ovarian Serous Cystadenocarcinoma (TCGA, Nature 2011) ov_tcga_pubTCGA

316 cases with simple somatic mutation data · 489 cases total · 2026-01-21 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	303	316	95.9%	cbioportal
2	TTN	Ssm	55	316	17.4%	cbioportal
3	BRCA1	Ssm	37	316	11.7%	cbioportal
4	BRCA2	Ssm	34	316	10.8%	cbioportal
5	USH2A	Ssm	20	316	6.3%	cbioportal
6	CSMD3	Ssm	19	316	6%	cbioportal
8	MUC16	Ssm	18	316	5.7%	cbioportal
7	FAT3	Ssm	18	316	5.7%	cbioportal
9	LRP2	Ssm	15	316	4.7%	cbioportal
10	HMCN1	Ssm	14	316	4.4%	cbioportal
11	RYR2	Ssm	14	316	4.4%	cbioportal
12	LRP1B	Ssm	13	316	4.1%	cbioportal
13	AHNAK	Ssm	12	316	3.8%	cbioportal
14	DNAH3	Ssm	12	316	3.8%	cbioportal
16	NF1	Ssm	12	316	3.8%	cbioportal
15	DNAH5	Ssm	12	316	3.8%	cbioportal
18	APOB	Ssm	11	316	3.5%	cbioportal
17	AHNAK2	Ssm	11	316	3.5%	cbioportal
22	TENM1	Ssm	11	316	3.5%	cbioportal
21	MUC17	Ssm	11	316	3.5%	cbioportal
20	HYDIN	Ssm	11	316	3.5%	cbioportal
19	FAT1	Ssm	11	316	3.5%	cbioportal
25	LRRK2	Ssm	10	316	3.2%	cbioportal
23	COL6A3	Ssm	10	316	3.2%	cbioportal
26	RYR1	Ssm	10	316	3.2%	cbioportal
24	HUWE1	Ssm	10	316	3.2%	cbioportal
30	DST	Ssm	9	316	2.8%	cbioportal
28	CDK12	Ssm	9	316	2.8%	cbioportal
27	ADGRB3	Ssm	9	316	2.8%	cbioportal
29	COL22A1	Ssm	9	316	2.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-21

Ovarian Serous Cystadenocarcinoma (TCGA, PanCancer Atlas) ov_tcga_pan_can_atlas_2018TCGA

523 cases with simple somatic mutation data · 585 cases total · 2026-06-04 · mapped to High-Grade Serous Ovarian Cancer EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	373	523	71.3%	cbioportal
2	TTN	Ssm	110	523	21%	cbioportal
4	MUC16	Ssm	41	523	7.8%	cbioportal
3	FLG2	Ssm	41	523	7.8%	cbioportal
5	CSMD3	Ssm	38	523	7.3%	cbioportal
6	HMCN1	Ssm	34	523	6.5%	cbioportal
7	USH2A	Ssm	32	523	6.1%	cbioportal
10	NF1	Ssm	30	523	5.7%	cbioportal
9	FLG	Ssm	30	523	5.7%	cbioportal
8	AHNAK2	Ssm	30	523	5.7%	cbioportal
11	MACF1	Ssm	29	523	5.5%	cbioportal
12	RYR2	Ssm	28	523	5.4%	cbioportal
14	SYNE1	Ssm	26	523	5%	cbioportal
13	AHNAK	Ssm	26	523	5%	cbioportal
15	APOB	Ssm	24	523	4.6%	cbioportal
20	MUC17	Ssm	24	523	4.6%	cbioportal
19	LRP2	Ssm	24	523	4.6%	cbioportal
18	KMT2C	Ssm	24	523	4.6%	cbioportal
17	FAT3	Ssm	24	523	4.6%	cbioportal
16	DNAH3	Ssm	24	523	4.6%	cbioportal
21	RYR1	Ssm	23	523	4.4%	cbioportal
23	DST	Ssm	22	523	4.2%	cbioportal
25	SI	Ssm	22	523	4.2%	cbioportal
22	COL6A3	Ssm	22	523	4.2%	cbioportal
24	MDN1	Ssm	22	523	4.2%	cbioportal
29	MYH1	Ssm	21	523	4%	cbioportal
26	DNAH5	Ssm	21	523	4%	cbioportal
27	FCGBP	Ssm	21	523	4%	cbioportal
28	LRP1B	Ssm	21	523	4%	cbioportal
30	FAT4	Ssm	20	523	3.8%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Papillary Renal Cell Carcinoma (TCGA GDC, 2025) prcc_tcga_gdcTCGA GDC

279 cases with simple somatic mutation data · 292 cases total · 2026-01-13 · mapped to Papillary Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	40	279	14.3%	cbioportal
2	MUC16	Ssm	22	279	7.9%	cbioportal
3	MET	Ssm	20	279	7.2%	cbioportal
4	KMT2C	Ssm	18	279	6.5%	cbioportal
6	PKHD1	Ssm	15	279	5.4%	cbioportal
5	BLTP1	Ssm	15	279	5.4%	cbioportal
7	SETD2	Ssm	15	279	5.4%	cbioportal
9	CUBN	Ssm	14	279	5%	cbioportal
8	BAP1	Ssm	14	279	5%	cbioportal
10	FAT1	Ssm	14	279	5%	cbioportal
12	SYNE1	Ssm	13	279	4.7%	cbioportal
13	USH2A	Ssm	13	279	4.7%	cbioportal
11	KMT2D	Ssm	13	279	4.7%	cbioportal
17	WDFY3	Ssm	12	279	4.3%	cbioportal
14	DNAH8	Ssm	12	279	4.3%	cbioportal
15	HERC2	Ssm	12	279	4.3%	cbioportal
16	SYNE2	Ssm	12	279	4.3%	cbioportal
18	ARID1A	Ssm	11	279	3.9%	cbioportal
19	LRP2	Ssm	11	279	3.9%	cbioportal
20	OBSCN	Ssm	11	279	3.9%	cbioportal
21	PBRM1	Ssm	11	279	3.9%	cbioportal
22	PCF11	Ssm	11	279	3.9%	cbioportal
23	CUL3	Ssm	10	279	3.6%	cbioportal
24	KDM6A	Ssm	10	279	3.6%	cbioportal
25	MACF1	Ssm	10	279	3.6%	cbioportal
26	SRRM2	Ssm	10	279	3.6%	cbioportal
27	ADGRV1	Ssm	9	279	3.2%	cbioportal
28	ANK3	Ssm	9	279	3.2%	cbioportal
29	BIRC6	Ssm	9	279	3.2%	cbioportal
30	HERC1	Ssm	9	279	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma TCGA-PRADTCGA

500 cases with simple somatic mutation data · 500 cases total · Data Release 46.0 · mapped to Prostate Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CCAR2	Ssm	298	500	59.6%	gdc
3	BIN3	Ssm	297	500	59.4%	gdc
2	XPO7	Ssm	297	500	59.4%	gdc
4	C8orf58	Ssm	297	500	59.4%	gdc
11	AC037459.1	Ssm	296	500	59.2%	gdc
9	PPP3CC	Ssm	296	500	59.2%	gdc
8	BMP1	Ssm	296	500	59.2%	gdc
7	PIWIL2	Ssm	296	500	59.2%	gdc
12	PEBP4	Ssm	296	500	59.2%	gdc
6	RHOBTB2	Ssm	296	500	59.2%	gdc
5	SORBS3	Ssm	296	500	59.2%	gdc
10	TNFRSF10C	Ssm	296	500	59.2%	gdc
23	TNFRSF10A	Ssm	295	500	59%	gdc
18	DOK2	Ssm	295	500	59%	gdc
17	DMTN	Ssm	295	500	59%	gdc
16	REEP4	Ssm	295	500	59%	gdc
15	EGR3	Ssm	295	500	59%	gdc
14	AC107959.5	Ssm	295	500	59%	gdc
13	HR	Ssm	295	500	59%	gdc
20	TNFRSF10D	Ssm	295	500	59%	gdc
19	POLR3D	Ssm	295	500	59%	gdc
22	PDLIM2	Ssm	295	500	59%	gdc
21	FAM160B2	Ssm	295	500	59%	gdc
30	SLC25A37	Ssm	294	500	58.8%	gdc
24	CHMP7	Ssm	294	500	58.8%	gdc
25	TNFRSF10B	Ssm	294	500	58.8%	gdc
26	NKX3-1	Ssm	294	500	58.8%	gdc
27	LGI3	Ssm	294	500	58.8%	gdc
28	NPM2	Ssm	294	500	58.8%	gdc
29	R3HCC1	Ssm	294	500	58.8%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Prostate Adenocarcinoma (Broad/Cornell, Cell 2013) prad_broad_2013Broad/Cornell

57 cases with simple somatic mutation data · 82 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	7	57	12.3%	cbioportal
4	TP53	Ssm	6	57	10.5%	cbioportal
3	MUC16	Ssm	6	57	10.5%	cbioportal
2	ATM	Ssm	6	57	10.5%	cbioportal
6	KMT2C	Ssm	5	57	8.8%	cbioportal
5	FOXA1	Ssm	5	57	8.8%	cbioportal
7	MACF1	Ssm	5	57	8.8%	cbioportal
13	ZAN	Ssm	4	57	7%	cbioportal
11	SPOP	Ssm	4	57	7%	cbioportal
10	PLCB3	Ssm	4	57	7%	cbioportal
9	FLG	Ssm	4	57	7%	cbioportal
8	BRINP2	Ssm	4	57	7%	cbioportal
12	TTN	Ssm	4	57	7%	cbioportal
18	C10ORF90	Ssm	3	57	5.3%	cbioportal
30	MUC2	Ssm	3	57	5.3%	cbioportal
29	KRT8	Ssm	3	57	5.3%	cbioportal
28	IGSF10	Ssm	3	57	5.3%	cbioportal
27	FBN3	Ssm	3	57	5.3%	cbioportal
26	FASN	Ssm	3	57	5.3%	cbioportal
25	DYNC2I1	Ssm	3	57	5.3%	cbioportal
24	DMD	Ssm	3	57	5.3%	cbioportal
23	CSMD3	Ssm	3	57	5.3%	cbioportal
22	CS	Ssm	3	57	5.3%	cbioportal
21	CREB3L4	Ssm	3	57	5.3%	cbioportal
20	CLIC6	Ssm	3	57	5.3%	cbioportal
19	CD8B	Ssm	3	57	5.3%	cbioportal
17	BICD2	Ssm	3	57	5.3%	cbioportal
16	APC	Ssm	3	57	5.3%	cbioportal
15	ANK2	Ssm	3	57	5.3%	cbioportal
14	ABCC9	Ssm	3	57	5.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (Broad/Cornell, Nat Genet 2012) prad_broadBroad/Cornell

112 cases with simple somatic mutation data · 123 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	14	112	12.5%	cbioportal
2	TTN	Ssm	11	112	9.8%	cbioportal
3	THSD7B	Ssm	7	112	6.3%	cbioportal
4	TP53	Ssm	7	112	6.3%	cbioportal
7	MED12	Ssm	6	112	5.4%	cbioportal
6	HMCN1	Ssm	6	112	5.4%	cbioportal
8	SCN11A	Ssm	6	112	5.4%	cbioportal
9	SPTA1	Ssm	6	112	5.4%	cbioportal
5	FAT4	Ssm	6	112	5.4%	cbioportal
15	OBSCN	Ssm	5	112	4.5%	cbioportal
17	SYNE3	Ssm	5	112	4.5%	cbioportal
16	PTEN	Ssm	5	112	4.5%	cbioportal
10	ABCA13	Ssm	5	112	4.5%	cbioportal
11	FAT1	Ssm	5	112	4.5%	cbioportal
12	FLG	Ssm	5	112	4.5%	cbioportal
13	MDN1	Ssm	5	112	4.5%	cbioportal
14	NBAS	Ssm	5	112	4.5%	cbioportal
19	CD1A	Ssm	4	112	3.6%	cbioportal
18	CACNA1E	Ssm	4	112	3.6%	cbioportal
30	MYO18B	Ssm	4	112	3.6%	cbioportal
29	MUC16	Ssm	4	112	3.6%	cbioportal
28	LRP1B	Ssm	4	112	3.6%	cbioportal
27	ITPR1	Ssm	4	112	3.6%	cbioportal
26	FRAS1	Ssm	4	112	3.6%	cbioportal
25	FOXA1	Ssm	4	112	3.6%	cbioportal
24	FNDC1	Ssm	4	112	3.6%	cbioportal
23	FMN2	Ssm	4	112	3.6%	cbioportal
22	DISP3	Ssm	4	112	3.6%	cbioportal
21	CUX1	Ssm	4	112	3.6%	cbioportal
20	CTNNA2	Ssm	4	112	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (CPC-GENE, Nature 2017) prad_cpcg_2017CPC-GENE

477 cases with simple somatic mutation data · 477 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	38	477	8%	cbioportal
2	TTN	Ssm	21	477	4.4%	cbioportal
3	TP53	Ssm	16	477	3.4%	cbioportal
4	MUC16	Ssm	12	477	2.5%	cbioportal
5	FOXA1	Ssm	11	477	2.3%	cbioportal
6	MED12	Ssm	11	477	2.3%	cbioportal
7	C6	Ssm	9	477	1.9%	cbioportal
10	RYR2	Ssm	9	477	1.9%	cbioportal
9	QRICH2	Ssm	9	477	1.9%	cbioportal
8	PRB4	Ssm	9	477	1.9%	cbioportal
12	KMT2C	Ssm	8	477	1.7%	cbioportal
11	ATM	Ssm	8	477	1.7%	cbioportal
14	SYNE1	Ssm	7	477	1.5%	cbioportal
13	PCDH15	Ssm	7	477	1.5%	cbioportal
15	TPTE	Ssm	7	477	1.5%	cbioportal
19	CSMD3	Ssm	6	477	1.3%	cbioportal
21	SPTA1	Ssm	6	477	1.3%	cbioportal
20	FAT3	Ssm	6	477	1.3%	cbioportal
18	C9	Ssm	6	477	1.3%	cbioportal
17	AHNAK2	Ssm	6	477	1.3%	cbioportal
16	ADAMTS20	Ssm	6	477	1.3%	cbioportal
29	FAT1	Ssm	5	477	1%	cbioportal
28	DCAF4L2	Ssm	5	477	1%	cbioportal
27	COL11A1	Ssm	5	477	1%	cbioportal
23	C3	Ssm	5	477	1%	cbioportal
24	C7	Ssm	5	477	1%	cbioportal
25	CFAP65	Ssm	5	477	1%	cbioportal
22	ANK2	Ssm	5	477	1%	cbioportal
30	FNDC1	Ssm	5	477	1%	cbioportal
26	CNTNAP5	Ssm	5	477	1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (Fred Hutchinson CRC, Nat Med 2016) prad_fhcrcFred Hutchinson CRC

141 cases with simple somatic mutation data · 176 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	57	141	40.4%	cbioportal
5	TTN	Ssm	18	141	12.8%	cbioportal
3	MUC16	Ssm	18	141	12.8%	cbioportal
2	CSMD3	Ssm	18	141	12.8%	cbioportal
4	RNF213	Ssm	18	141	12.8%	cbioportal
6	DCHS2	Ssm	17	141	12.1%	cbioportal
7	OBSCN	Ssm	17	141	12.1%	cbioportal
11	RYR2	Ssm	16	141	11.3%	cbioportal
8	ATM	Ssm	16	141	11.3%	cbioportal
9	HERC2	Ssm	16	141	11.3%	cbioportal
10	LRP1B	Ssm	16	141	11.3%	cbioportal
12	CDH11	Ssm	15	141	10.6%	cbioportal
15	ZFHX3	Ssm	15	141	10.6%	cbioportal
14	TICRR	Ssm	15	141	10.6%	cbioportal
13	DNAH6	Ssm	15	141	10.6%	cbioportal
17	CENPF	Ssm	14	141	9.9%	cbioportal
20	PLCG1	Ssm	14	141	9.9%	cbioportal
16	ABCA13	Ssm	14	141	9.9%	cbioportal
19	PCDHA6	Ssm	14	141	9.9%	cbioportal
21	SPTA1	Ssm	14	141	9.9%	cbioportal
18	KMT2D	Ssm	14	141	9.9%	cbioportal
24	LRRK2	Ssm	13	141	9.2%	cbioportal
22	DNAH1	Ssm	13	141	9.2%	cbioportal
23	HECTD1	Ssm	13	141	9.2%	cbioportal
25	SKIC3	Ssm	13	141	9.2%	cbioportal
26	SYNE1	Ssm	13	141	9.2%	cbioportal
27	APOBEC3G	Ssm	12	141	8.5%	cbioportal
30	DYNC2H1	Ssm	12	141	8.5%	cbioportal
29	CDH12	Ssm	12	141	8.5%	cbioportal
28	C7	Ssm	12	141	8.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (MSK, 2025) prad_msk_2025MSK

120 cases with simple somatic mutation data · 120 cases total · 2026-03-04 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	31	120	25.8%	cbioportal
2	BRCA2	Ssm	22	120	18.3%	cbioportal
3	ZFHX3	Ssm	15	116	12.9%	cbioportal
4	FOXA1	Ssm	14	120	11.7%	cbioportal
5	KMT2C	Ssm	14	120	11.7%	cbioportal
6	CDK12	Ssm	12	120	10%	cbioportal
7	ATM	Ssm	10	120	8.3%	cbioportal
9	SPOP	Ssm	9	120	7.5%	cbioportal
8	KMT2D	Ssm	9	120	7.5%	cbioportal
10	SPEN	Ssm	8	120	6.7%	cbioportal
14	MGA	Ssm	7	116	6%	cbioportal
13	BRCA1	Ssm	7	120	5.8%	cbioportal
12	AR	Ssm	7	120	5.8%	cbioportal
11	APC	Ssm	7	120	5.8%	cbioportal
27	TP53BP1	Ssm	5	90	5.6%	cbioportal
18	PTCH1	Ssm	6	120	5%	cbioportal
16	KMT2A	Ssm	6	120	5%	cbioportal
17	NCOR1	Ssm	6	120	5%	cbioportal
19	PTEN	Ssm	6	120	5%	cbioportal
20	PTPRD	Ssm	6	120	5%	cbioportal
15	CTNNB1	Ssm	6	120	5%	cbioportal
184	GNB1	Ssm	1	22	4.5%	cbioportal
150	ARHGAP35	Ssm	1	22	4.5%	cbioportal
31	CARM1	Ssm	4	90	4.4%	cbioportal
35	ERF	Ssm	4	90	4.4%	cbioportal
21	ANKRD11	Ssm	5	116	4.3%	cbioportal
24	NOTCH2	Ssm	5	120	4.2%	cbioportal
23	MED12	Ssm	5	120	4.2%	cbioportal
22	KDM6A	Ssm	5	120	4.2%	cbioportal
26	SMARCA4	Ssm	5	120	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-03-04

Prostate Adenocarcinoma (MSK, Cancer Cell 2010) prad_mskccMSK

182 cases with simple somatic mutation data · 240 cases total · 2026-02-19 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
69	STAT5B	Ssm	2	9	22.2%	cbioportal
66	ROS1	Ssm	2	9	22.2%	cbioportal
106	NSD1	Ssm	1	9	11.1%	cbioportal
81	ELK1	Ssm	1	9	11.1%	cbioportal
80	EGF	Ssm	1	9	11.1%	cbioportal
107	PDGFRB	Ssm	1	9	11.1%	cbioportal
78	CASP9	Ssm	1	9	11.1%	cbioportal
110	PRKCZ	Ssm	1	9	11.1%	cbioportal
111	PTK2	Ssm	1	9	11.1%	cbioportal
75	BLK	Ssm	1	9	11.1%	cbioportal
121	TYK2	Ssm	1	9	11.1%	cbioportal
103	MUTYH	Ssm	1	9	11.1%	cbioportal
97	LCK	Ssm	1	9	11.1%	cbioportal
92	JAK2	Ssm	1	9	11.1%	cbioportal
88	FES	Ssm	1	9	11.1%	cbioportal
89	FGF1	Ssm	1	9	11.1%	cbioportal
119	SRC	Ssm	1	9	11.1%	cbioportal
90	IDH2	Ssm	1	9	11.1%	cbioportal
115	RAC3	Ssm	1	9	11.1%	cbioportal
120	STAT1	Ssm	1	9	11.1%	cbioportal
100	MAPK7	Ssm	1	9	11.1%	cbioportal
114	PTPN6	Ssm	1	9	11.1%	cbioportal
85	ETS2	Ssm	1	9	11.1%	cbioportal
1	PTPRF	Ssm	9	106	8.5%	cbioportal
2	EP300	Ssm	7	106	6.6%	cbioportal
4	FLT4	Ssm	6	106	5.7%	cbioportal
3	AR	Ssm	6	106	5.7%	cbioportal
8	JAK1	Ssm	5	106	4.7%	cbioportal
10	PTK7	Ssm	5	106	4.7%	cbioportal
9	NCOR2	Ssm	5	106	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Prostate Adenocarcinoma (MSK, Clin Cancer Res. 2022) prad_pik3r1_msk_2021MSK

1,417 cases with simple somatic mutation data · 1,417 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	411	1,417	29%	cbioportal
2	SPOP	Ssm	200	1,417	14.1%	cbioportal
3	FOXA1	Ssm	197	1,417	13.9%	cbioportal
4	APC	Ssm	124	1,417	8.8%	cbioportal
5	PTEN	Ssm	119	1,417	8.4%	cbioportal
6	KMT2C	Ssm	81	1,417	5.7%	cbioportal
8	ZFHX3	Ssm	75	1,361	5.5%	cbioportal
7	KMT2D	Ssm	76	1,417	5.4%	cbioportal
9	CDK12	Ssm	67	1,417	4.7%	cbioportal
10	CTNNB1	Ssm	61	1,417	4.3%	cbioportal
11	PIK3CA	Ssm	60	1,417	4.2%	cbioportal
12	ATM	Ssm	59	1,417	4.2%	cbioportal
13	BRCA2	Ssm	56	1,417	4%	cbioportal
14	AR	Ssm	53	1,417	3.7%	cbioportal
15	PIK3R1	Ssm	48	1,417	3.4%	cbioportal
16	KDM6A	Ssm	44	1,417	3.1%	cbioportal
17	MGA	Ssm	39	1,361	2.9%	cbioportal
18	RB1	Ssm	36	1,417	2.5%	cbioportal
19	MED12	Ssm	35	1,417	2.5%	cbioportal
20	PTPRD	Ssm	31	1,417	2.2%	cbioportal
21	GRIN2A	Ssm	28	1,417	2%	cbioportal
22	ASXL2	Ssm	27	1,417	1.9%	cbioportal
23	EPHB1	Ssm	26	1,417	1.8%	cbioportal
25	SPEN	Ssm	26	1,417	1.8%	cbioportal
24	JAK1	Ssm	26	1,417	1.8%	cbioportal
27	SF3B1	Ssm	25	1,417	1.8%	cbioportal
26	NCOR1	Ssm	25	1,417	1.8%	cbioportal
28	ARID1A	Ssm	23	1,417	1.6%	cbioportal
30	BRAF	Ssm	22	1,417	1.6%	cbioportal
29	ASXL1	Ssm	22	1,417	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (MSK/DFCI, Nature Genetics 2018) prad_p1000MSK/DFCI

1,013 cases with simple somatic mutation data · 1,013 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	189	1,013	18.7%	cbioportal
2	TTN	Ssm	151	1,013	14.9%	cbioportal
3	MUC16	Ssm	113	1,013	11.2%	cbioportal
4	SPOP	Ssm	92	1,013	9.1%	cbioportal
5	SYNE1	Ssm	73	1,013	7.2%	cbioportal
6	FOXA1	Ssm	69	1,013	6.8%	cbioportal
7	KMT2C	Ssm	66	1,013	6.5%	cbioportal
8	KMT2D	Ssm	65	1,013	6.4%	cbioportal
9	CSMD3	Ssm	61	1,013	6%	cbioportal
10	HMCN1	Ssm	55	1,013	5.4%	cbioportal
11	LRP1B	Ssm	54	1,013	5.3%	cbioportal
12	OBSCN	Ssm	53	1,013	5.2%	cbioportal
13	AR	Ssm	48	1,013	4.7%	cbioportal
14	SPTA1	Ssm	47	1,013	4.6%	cbioportal
15	USH2A	Ssm	46	1,013	4.5%	cbioportal
16	RYR1	Ssm	45	1,013	4.4%	cbioportal
18	RYR2	Ssm	44	1,013	4.3%	cbioportal
17	PTEN	Ssm	44	1,013	4.3%	cbioportal
19	ABCA13	Ssm	43	1,013	4.2%	cbioportal
20	FAT3	Ssm	41	1,013	4%	cbioportal
21	ZFHX3	Ssm	41	1,013	4%	cbioportal
22	DCHS2	Ssm	40	1,013	3.9%	cbioportal
23	FAT4	Ssm	39	1,013	3.8%	cbioportal
24	ATM	Ssm	38	1,013	3.8%	cbioportal
26	CSMD1	Ssm	37	1,013	3.7%	cbioportal
25	CACNA1E	Ssm	37	1,013	3.7%	cbioportal
27	DNAH3	Ssm	36	1,013	3.6%	cbioportal
30	XIRP2	Ssm	34	1,013	3.4%	cbioportal
29	MYO15A	Ssm	34	1,013	3.4%	cbioportal
28	MUC4	Ssm	34	1,013	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (MSK, Eur Urol 2020) prad_cdk12_mskcc_2020MSK

1,465 cases with simple somatic mutation data · 1,465 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	391	1,465	26.7%	cbioportal
2	FOXA1	Ssm	179	1,465	12.2%	cbioportal
3	SPOP	Ssm	166	1,465	11.3%	cbioportal
4	PTEN	Ssm	97	1,465	6.6%	cbioportal
5	KMT2C	Ssm	89	1,465	6.1%	cbioportal
6	CDK12	Ssm	88	1,465	6%	cbioportal
7	APC	Ssm	86	1,465	5.9%	cbioportal
8	KMT2D	Ssm	74	1,465	5.1%	cbioportal
9	AR	Ssm	56	1,465	3.8%	cbioportal
13	ZFHX3	Ssm	51	1,337	3.8%	cbioportal
10	CTNNB1	Ssm	55	1,465	3.8%	cbioportal
11	ATM	Ssm	52	1,465	3.5%	cbioportal
12	PIK3CA	Ssm	52	1,465	3.5%	cbioportal
14	BRCA2	Ssm	45	1,465	3.1%	cbioportal
15	KDM6A	Ssm	38	1,465	2.6%	cbioportal
16	GRIN2A	Ssm	36	1,465	2.5%	cbioportal
17	MED12	Ssm	31	1,465	2.1%	cbioportal
18	PTPRD	Ssm	30	1,465	2%	cbioportal
19	SPEN	Ssm	28	1,465	1.9%	cbioportal
20	RB1	Ssm	27	1,465	1.8%	cbioportal
24	MGA	Ssm	24	1,337	1.8%	cbioportal
21	BRAF	Ssm	26	1,465	1.8%	cbioportal
48	ERF	Ssm	14	809	1.7%	cbioportal
22	PIK3R1	Ssm	25	1,465	1.7%	cbioportal
23	ASXL1	Ssm	24	1,465	1.6%	cbioportal
25	NCOR1	Ssm	24	1,465	1.6%	cbioportal
26	ARID1A	Ssm	23	1,465	1.6%	cbioportal
27	JAK1	Ssm	23	1,465	1.6%	cbioportal
29	NF1	Ssm	23	1,465	1.6%	cbioportal
28	KMT2A	Ssm	23	1,465	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma Organoids (MSK, Cell 2014) prad_mskcc_cheny1_organoids_2014MSK

12 cases with simple somatic mutation data · 12 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	7	12	58.3%	cbioportal
2	TBP	Ssm	6	12	50%	cbioportal
3	LCE4A	Ssm	4	12	33.3%	cbioportal
11	KRT72	Ssm	3	12	25%	cbioportal
4	ABHD15	Ssm	3	12	25%	cbioportal
5	ATXN1	Ssm	3	12	25%	cbioportal
6	CRACD	Ssm	3	12	25%	cbioportal
7	FOXA1	Ssm	3	12	25%	cbioportal
8	GIT2	Ssm	3	12	25%	cbioportal
9	KIRREL1	Ssm	3	12	25%	cbioportal
10	KRT1	Ssm	3	12	25%	cbioportal
12	NKX6-2	Ssm	3	12	25%	cbioportal
13	SCN5A	Ssm	3	12	25%	cbioportal
14	SPATA3	Ssm	3	12	25%	cbioportal
15	SPATA31D1	Ssm	3	12	25%	cbioportal
16	TRIOBP	Ssm	3	12	25%	cbioportal
21	AEBP1	Ssm	2	12	16.7%	cbioportal
22	AGO3	Ssm	2	12	16.7%	cbioportal
20	ADCY1	Ssm	2	12	16.7%	cbioportal
17	A1BG	Ssm	2	12	16.7%	cbioportal
18	ACTL9	Ssm	2	12	16.7%	cbioportal
124	RUFY4	Ssm	2	12	16.7%	cbioportal
19	ADAMTS12	Ssm	2	12	16.7%	cbioportal
29	ASPM	Ssm	2	12	16.7%	cbioportal
28	ART5	Ssm	2	12	16.7%	cbioportal
27	ARID3B	Ssm	2	12	16.7%	cbioportal
26	ARGFX	Ssm	2	12	16.7%	cbioportal
25	APOL4	Ssm	2	12	16.7%	cbioportal
24	ANO1	Ssm	2	12	16.7%	cbioportal
23	ANK2	Ssm	2	12	16.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (SMMU, Eur Urol 2017) prad_eururol_2017SMMU

65 cases with simple somatic mutation data · 65 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	11	65	16.9%	cbioportal
2	KDM6A	Ssm	5	65	7.7%	cbioportal
3	KMT2D	Ssm	4	65	6.2%	cbioportal
9	TP53	Ssm	3	65	4.6%	cbioportal
8	SEMA5A	Ssm	3	65	4.6%	cbioportal
7	RYR1	Ssm	3	65	4.6%	cbioportal
4	COL22A1	Ssm	3	65	4.6%	cbioportal
6	PTEN	Ssm	3	65	4.6%	cbioportal
5	MYH2	Ssm	3	65	4.6%	cbioportal
62	RBM46	Ssm	2	65	3.1%	cbioportal
54	NLRC5	Ssm	2	65	3.1%	cbioportal
55	NUP133	Ssm	2	65	3.1%	cbioportal
56	PKHD1	Ssm	2	65	3.1%	cbioportal
57	PKHD1L1	Ssm	2	65	3.1%	cbioportal
58	PLXNA4	Ssm	2	65	3.1%	cbioportal
59	PPP2R3C	Ssm	2	65	3.1%	cbioportal
60	PREX2	Ssm	2	65	3.1%	cbioportal
61	PSAPL1	Ssm	2	65	3.1%	cbioportal
63	RPTN	Ssm	2	65	3.1%	cbioportal
64	RUNX1T1	Ssm	2	65	3.1%	cbioportal
65	RYR2	Ssm	2	65	3.1%	cbioportal
66	SCN5A	Ssm	2	65	3.1%	cbioportal
67	SERPINA11	Ssm	2	65	3.1%	cbioportal
68	SLC25A26	Ssm	2	65	3.1%	cbioportal
69	SLC2A6	Ssm	2	65	3.1%	cbioportal
70	SUOX	Ssm	2	65	3.1%	cbioportal
71	TLR6	Ssm	2	65	3.1%	cbioportal
72	TRIP12	Ssm	2	65	3.1%	cbioportal
73	TTN	Ssm	2	65	3.1%	cbioportal
74	UBR1	Ssm	2	65	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (TCGA, Cell 2015) prad_tcga_pubTCGA

333 cases with simple somatic mutation data · 333 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	37	333	11.1%	cbioportal
2	TTN	Ssm	37	333	11.1%	cbioportal
3	TP53	Ssm	23	333	6.9%	cbioportal
4	MUC16	Ssm	20	333	6%	cbioportal
5	MUC17	Ssm	17	333	5.1%	cbioportal
6	SPTA1	Ssm	15	333	4.5%	cbioportal
8	FOXA1	Ssm	13	333	3.9%	cbioportal
9	KMT2C	Ssm	13	333	3.9%	cbioportal
7	ATM	Ssm	13	333	3.9%	cbioportal
11	CSMD3	Ssm	12	333	3.6%	cbioportal
10	AHNAK2	Ssm	12	333	3.6%	cbioportal
12	LRP1B	Ssm	12	333	3.6%	cbioportal
14	OBSCN	Ssm	11	333	3.3%	cbioportal
13	KMT2D	Ssm	11	333	3.3%	cbioportal
15	AHNAK	Ssm	10	333	3%	cbioportal
18	RP1	Ssm	10	333	3%	cbioportal
17	HMCN1	Ssm	10	333	3%	cbioportal
16	FAT3	Ssm	10	333	3%	cbioportal
22	PTEN	Ssm	9	333	2.7%	cbioportal
19	BRCA2	Ssm	9	333	2.7%	cbioportal
20	DCHS2	Ssm	9	333	2.7%	cbioportal
21	FLG2	Ssm	9	333	2.7%	cbioportal
25	BRAF	Ssm	8	333	2.4%	cbioportal
23	ADGRB3	Ssm	8	333	2.4%	cbioportal
30	PCDH18	Ssm	8	333	2.4%	cbioportal
29	MACF1	Ssm	8	333	2.4%	cbioportal
28	FLG	Ssm	8	333	2.4%	cbioportal
27	DNAH9	Ssm	8	333	2.4%	cbioportal
26	CTNNB1	Ssm	8	333	2.4%	cbioportal
24	ADGRV1	Ssm	8	333	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (TCGA, Firehose Legacy) prad_tcgaTCGA

499 cases with simple somatic mutation data · 501 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FRG1BP	Ssm	97	499	19.4%	cbioportal
2	TTN	Ssm	63	499	12.6%	cbioportal
3	TP53	Ssm	61	499	12.2%	cbioportal
4	SPOP	Ssm	57	499	11.4%	cbioportal
5	MUC16	Ssm	38	499	7.6%	cbioportal
6	MUC17	Ssm	33	499	6.6%	cbioportal
7	KMT2C	Ssm	30	499	6%	cbioportal
8	KMT2D	Ssm	29	499	5.8%	cbioportal
9	FOXA1	Ssm	28	499	5.6%	cbioportal
11	SYNE1	Ssm	27	499	5.4%	cbioportal
10	NBPF1	Ssm	27	499	5.4%	cbioportal
12	SPTA1	Ssm	26	499	5.2%	cbioportal
14	LRP1B	Ssm	24	499	4.8%	cbioportal
13	KRTAP4-11	Ssm	24	499	4.8%	cbioportal
15	NBPF10	Ssm	23	499	4.6%	cbioportal
17	CSMD3	Ssm	22	499	4.4%	cbioportal
18	ZAN	Ssm	22	499	4.4%	cbioportal
16	ATM	Ssm	22	499	4.4%	cbioportal
20	MUC4	Ssm	21	499	4.2%	cbioportal
19	CHEK2	Ssm	21	499	4.2%	cbioportal
23	RYR1	Ssm	19	499	3.8%	cbioportal
22	HMCN1	Ssm	19	499	3.8%	cbioportal
21	FAT3	Ssm	19	499	3.8%	cbioportal
27	USH2A	Ssm	18	499	3.6%	cbioportal
25	OBSCN	Ssm	18	499	3.6%	cbioportal
24	CACNA1E	Ssm	18	499	3.6%	cbioportal
26	RGPD8	Ssm	18	499	3.6%	cbioportal
30	RYR2	Ssm	17	499	3.4%	cbioportal
28	MACF1	Ssm	17	499	3.4%	cbioportal
29	PTEN	Ssm	17	499	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (TCGA GDC, 2025) prad_tcga_gdcTCGA GDC

491 cases with simple somatic mutation data · 501 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	55	491	11.2%	cbioportal
2	SPOP	Ssm	54	491	11%	cbioportal
3	TTN	Ssm	47	491	9.6%	cbioportal
4	FOXA1	Ssm	29	491	5.9%	cbioportal
5	KMT2D	Ssm	28	491	5.7%	cbioportal
6	MUC16	Ssm	26	491	5.3%	cbioportal
7	SYNE1	Ssm	22	491	4.5%	cbioportal
8	KMT2C	Ssm	21	491	4.3%	cbioportal
10	SPTA1	Ssm	20	491	4.1%	cbioportal
9	LRP1B	Ssm	20	491	4.1%	cbioportal
11	ATM	Ssm	18	491	3.7%	cbioportal
12	CSMD3	Ssm	17	491	3.5%	cbioportal
13	RYR2	Ssm	17	491	3.5%	cbioportal
14	PTEN	Ssm	16	491	3.3%	cbioportal
15	KDM6A	Ssm	15	491	3.1%	cbioportal
17	HMCN1	Ssm	14	491	2.9%	cbioportal
16	CACNA1E	Ssm	14	491	2.9%	cbioportal
18	MUC17	Ssm	14	491	2.9%	cbioportal
19	RP1	Ssm	13	491	2.6%	cbioportal
20	USH2A	Ssm	13	491	2.6%	cbioportal
22	MYO15A	Ssm	12	491	2.4%	cbioportal
21	FAT3	Ssm	12	491	2.4%	cbioportal
23	RYR1	Ssm	12	491	2.4%	cbioportal
26	APC	Ssm	11	491	2.2%	cbioportal
24	ABCA13	Ssm	11	491	2.2%	cbioportal
25	ADGRB3	Ssm	11	491	2.2%	cbioportal
27	CNTNAP5	Ssm	11	491	2.2%	cbioportal
28	MACF1	Ssm	11	491	2.2%	cbioportal
29	OBSCN	Ssm	11	491	2.2%	cbioportal
30	ZMYM3	Ssm	11	491	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (TCGA, PanCancer Atlas) prad_tcga_pan_can_atlas_2018TCGA

494 cases with simple somatic mutation data · 494 cases total · 2026-06-04 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	57	494	11.5%	cbioportal
2	SPOP	Ssm	55	494	11.1%	cbioportal
3	TTN	Ssm	54	494	10.9%	cbioportal
4	MUC16	Ssm	31	494	6.3%	cbioportal
5	FOXA1	Ssm	28	494	5.7%	cbioportal
6	KMT2D	Ssm	28	494	5.7%	cbioportal
7	KMT2C	Ssm	25	494	5.1%	cbioportal
8	SPTA1	Ssm	23	494	4.7%	cbioportal
9	SYNE1	Ssm	23	494	4.7%	cbioportal
10	LRP1B	Ssm	22	494	4.5%	cbioportal
11	ATM	Ssm	20	494	4%	cbioportal
12	CSMD3	Ssm	19	494	3.8%	cbioportal
15	RYR2	Ssm	18	494	3.6%	cbioportal
13	FAT3	Ssm	18	494	3.6%	cbioportal
14	PTEN	Ssm	18	494	3.6%	cbioportal
17	OBSCN	Ssm	16	494	3.2%	cbioportal
16	HMCN1	Ssm	16	494	3.2%	cbioportal
22	USH2A	Ssm	15	494	3%	cbioportal
21	RYR1	Ssm	15	494	3%	cbioportal
19	COL11A1	Ssm	15	494	3%	cbioportal
20	MUC17	Ssm	15	494	3%	cbioportal
18	CACNA1E	Ssm	15	494	3%	cbioportal
23	MACF1	Ssm	14	494	2.8%	cbioportal
24	MYO15A	Ssm	14	494	2.8%	cbioportal
25	RP1	Ssm	13	494	2.6%	cbioportal
26	ZFHX3	Ssm	13	494	2.6%	cbioportal
28	CSMD1	Ssm	12	494	2.4%	cbioportal
27	ABCA13	Ssm	12	494	2.4%	cbioportal
30	DNAH17	Ssm	12	494	2.4%	cbioportal
29	DCHS2	Ssm	12	494	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Prostate Cancer-IDH Driver Mutant Cohort (MSK, 2024) prad_idhmut_msk_2025MSK

99 cases with simple somatic mutation data · 99 cases total · 2026-08-20 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IDH1	Ssm	29	99	29.3%	cbioportal
2	TP53	Ssm	17	99	17.2%	cbioportal
3	FOXA1	Ssm	12	99	12.1%	cbioportal
4	SPOP	Ssm	12	99	12.1%	cbioportal
5	BRCA2	Ssm	6	99	6.1%	cbioportal
6	CTNNB1	Ssm	6	99	6.1%	cbioportal
7	PIK3CA	Ssm	6	99	6.1%	cbioportal
8	ATM	Ssm	5	99	5.1%	cbioportal
9	KMT2D	Ssm	5	99	5.1%	cbioportal
10	APC	Ssm	4	99	4%	cbioportal
13	PTEN	Ssm	4	99	4%	cbioportal
12	IDH2	Ssm	4	99	4%	cbioportal
11	CDK12	Ssm	4	99	4%	cbioportal
22	ZFHX3	Ssm	3	96	3.1%	cbioportal
19	MGA	Ssm	3	96	3.1%	cbioportal
17	KDM6A	Ssm	3	99	3%	cbioportal
16	JAK1	Ssm	3	99	3%	cbioportal
15	DNMT3B	Ssm	3	99	3%	cbioportal
21	TSC2	Ssm	3	99	3%	cbioportal
20	PTPRD	Ssm	3	99	3%	cbioportal
14	BCOR	Ssm	3	99	3%	cbioportal
18	KMT2A	Ssm	3	99	3%	cbioportal
40	NSD2	Ssm	2	89	2.2%	cbioportal
119	MAP3K7	Ssm	1	45	2.2%	cbioportal
51	ACVR1B	Ssm	1	45	2.2%	cbioportal
124	MLH3	Ssm	1	45	2.2%	cbioportal
93	FANCL	Ssm	1	45	2.2%	cbioportal
117	LRP1B	Ssm	1	45	2.2%	cbioportal
43	POLD1	Ssm	2	96	2.1%	cbioportal
31	FBXW7	Ssm	2	99	2%	cbioportal

Data updated 22 days agoSource updated 2026-08-20

Prostate Cancer (MSK, JCO Precis Oncol 2017) prad_mskcc_2017MSK

504 cases with simple somatic mutation data · 504 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	166	504	32.9%	cbioportal
2	FOXA1	Ssm	58	504	11.5%	cbioportal
3	SPOP	Ssm	47	504	9.3%	cbioportal
4	APC	Ssm	40	504	7.9%	cbioportal
5	KMT2C	Ssm	34	504	6.7%	cbioportal
6	PTEN	Ssm	28	504	5.6%	cbioportal
7	CDK12	Ssm	27	504	5.4%	cbioportal
9	KMT2D	Ssm	25	504	5%	cbioportal
8	AR	Ssm	25	504	5%	cbioportal
10	BRCA2	Ssm	24	504	4.8%	cbioportal
11	SPEN	Ssm	21	504	4.2%	cbioportal
12	GRIN2A	Ssm	19	504	3.8%	cbioportal
13	ATM	Ssm	18	504	3.6%	cbioportal
15	PIK3CA	Ssm	17	504	3.4%	cbioportal
14	CTNNB1	Ssm	17	504	3.4%	cbioportal
16	JAK1	Ssm	15	504	3%	cbioportal
30	ZFHX3	Ssm	10	345	2.9%	cbioportal
27	MGA	Ssm	10	345	2.9%	cbioportal
17	FAT1	Ssm	14	504	2.8%	cbioportal
18	RB1	Ssm	14	504	2.8%	cbioportal
21	NCOR1	Ssm	12	504	2.4%	cbioportal
19	KMT2A	Ssm	12	504	2.4%	cbioportal
20	MED12	Ssm	12	504	2.4%	cbioportal
22	ASXL1	Ssm	11	504	2.2%	cbioportal
23	KDM6A	Ssm	11	504	2.2%	cbioportal
25	PTPRS	Ssm	11	504	2.2%	cbioportal
24	NOTCH1	Ssm	11	504	2.2%	cbioportal
28	NSD1	Ssm	10	504	2%	cbioportal
29	PIK3R1	Ssm	10	504	2%	cbioportal
26	BRAF	Ssm	10	504	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Cancer (MSK, Science 2022) prad_organoids_msk_2022MSK

47 cases with simple somatic mutation data · 47 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	32	47	68.1%	cbioportal
5	MUC16	Ssm	7	24	29.2%	cbioportal
10	TTN	Ssm	6	24	25%	cbioportal
7	AEBP1	Ssm	6	24	25%	cbioportal
11	ABHD15	Ssm	5	24	20.8%	cbioportal
14	CDH23	Ssm	5	24	20.8%	cbioportal
16	DNAH2	Ssm	5	24	20.8%	cbioportal
26	TRIOBP	Ssm	5	24	20.8%	cbioportal
21	OBSCN	Ssm	5	24	20.8%	cbioportal
17	HERC1	Ssm	5	24	20.8%	cbioportal
18	LRP1B	Ssm	5	24	20.8%	cbioportal
20	MUC5B	Ssm	5	24	20.8%	cbioportal
19	MACF1	Ssm	5	24	20.8%	cbioportal
2	FOXA1	Ssm	8	47	17%	cbioportal
74	SYNE3	Ssm	4	24	16.7%	cbioportal
68	RYR1	Ssm	4	24	16.7%	cbioportal
66	RNF213	Ssm	4	24	16.7%	cbioportal
29	ANK2	Ssm	4	24	16.7%	cbioportal
28	AHNAK	Ssm	4	24	16.7%	cbioportal
48	ITPRID1	Ssm	4	24	16.7%	cbioportal
47	ITGA10	Ssm	4	24	16.7%	cbioportal
52	MUC6	Ssm	4	24	16.7%	cbioportal
53	MYO10	Ssm	4	24	16.7%	cbioportal
75	TRIM67	Ssm	4	24	16.7%	cbioportal
70	RYR3	Ssm	4	24	16.7%	cbioportal
71	SPATA31D1	Ssm	4	24	16.7%	cbioportal
51	MCF2L2	Ssm	4	24	16.7%	cbioportal
50	LAMA3	Ssm	4	24	16.7%	cbioportal
49	KCNQ5	Ssm	4	24	16.7%	cbioportal
69	RYR2	Ssm	4	24	16.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Race Differences in Prostate Cancer (MSK, 2021) prad_msk_stopsack_2021MSK

2,069 cases with simple somatic mutation data · 2,069 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	551	2,069	26.6%	cbioportal
2	FOXA1	Ssm	273	2,069	13.2%	cbioportal
3	SPOP	Ssm	260	2,069	12.6%	cbioportal
4	PTEN	Ssm	155	2,069	7.5%	cbioportal
5	KMT2C	Ssm	140	2,069	6.8%	cbioportal
6	APC	Ssm	138	2,069	6.7%	cbioportal
7	KMT2D	Ssm	133	2,069	6.4%	cbioportal
9	ZFHX3	Ssm	110	1,924	5.7%	cbioportal
8	CDK12	Ssm	118	2,069	5.7%	cbioportal
10	PIK3CA	Ssm	92	2,069	4.4%	cbioportal
11	ATM	Ssm	86	2,069	4.2%	cbioportal
12	AR	Ssm	80	2,069	3.9%	cbioportal
13	CTNNB1	Ssm	78	2,069	3.8%	cbioportal
14	BRCA2	Ssm	74	2,069	3.6%	cbioportal
15	SPEN	Ssm	70	2,069	3.4%	cbioportal
27	ERF	Ssm	47	1,402	3.4%	cbioportal
16	KDM6A	Ssm	69	2,069	3.3%	cbioportal
20	MGA	Ssm	61	1,924	3.2%	cbioportal
17	JAK1	Ssm	64	2,069	3.1%	cbioportal
18	RB1	Ssm	63	2,069	3%	cbioportal
19	GRIN2A	Ssm	61	2,069	2.9%	cbioportal
21	FAT1	Ssm	56	2,069	2.7%	cbioportal
23	MED12	Ssm	52	2,069	2.5%	cbioportal
22	KMT2A	Ssm	52	2,069	2.5%	cbioportal
25	NCOR1	Ssm	50	2,069	2.4%	cbioportal
24	ASXL1	Ssm	50	2,069	2.4%	cbioportal
26	PTPRD	Ssm	49	2,069	2.4%	cbioportal
44	KMT2B	Ssm	32	1,402	2.3%	cbioportal
28	ARID1A	Ssm	43	2,069	2.1%	cbioportal
29	PIK3R1	Ssm	41	2,069	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Renal Cell Carcinoma (CPTAC GDC, 2025) rcc_cptac_gdcCPTAC GDC

352 cases with simple somatic mutation data · 354 cases total · 2026-01-14 · mapped to Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	237	352	67.3%	cbioportal
2	PBRM1	Ssm	114	352	32.4%	cbioportal
3	BAP1	Ssm	48	352	13.6%	cbioportal
4	TTN	Ssm	44	352	12.5%	cbioportal
5	KDM5C	Ssm	43	352	12.2%	cbioportal
6	SETD2	Ssm	39	352	11.1%	cbioportal
7	CSMD3	Ssm	34	352	9.7%	cbioportal
8	MTOR	Ssm	23	352	6.5%	cbioportal
9	LRP2	Ssm	20	352	5.7%	cbioportal
10	MUC16	Ssm	20	352	5.7%	cbioportal
11	RYR2	Ssm	19	352	5.4%	cbioportal
12	USH2A	Ssm	19	352	5.4%	cbioportal
13	CUBN	Ssm	18	352	5.1%	cbioportal
15	YLPM1	Ssm	17	352	4.8%	cbioportal
14	MUC17	Ssm	17	352	4.8%	cbioportal
18	SYNE2	Ssm	16	352	4.5%	cbioportal
16	HMCN1	Ssm	16	352	4.5%	cbioportal
17	SYNE1	Ssm	16	352	4.5%	cbioportal
19	ZNF292	Ssm	16	352	4.5%	cbioportal
22	MACF1	Ssm	15	352	4.3%	cbioportal
20	DST	Ssm	15	352	4.3%	cbioportal
21	FSIP2	Ssm	15	352	4.3%	cbioportal
23	SI	Ssm	15	352	4.3%	cbioportal
26	DNAH5	Ssm	14	352	4%	cbioportal
24	APOB	Ssm	14	352	4%	cbioportal
25	BIRC6	Ssm	14	352	4%	cbioportal
27	PKD1	Ssm	14	352	4%	cbioportal
29	LRTM3	Ssm	13	352	3.7%	cbioportal
28	GOLGB1	Ssm	13	352	3.7%	cbioportal
30	MAP1A	Ssm	13	352	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Renal Cell Carcinoma (IMmotion150 Clinical Trial, Nat Med. 2018) - iAtlas Harmonized rcc_iatlas_immotion150_2018

158 cases with simple somatic mutation data · 263 cases total · 2026-02-11 · mapped to Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	106	158	67.1%	cbioportal
2	PBRM1	Ssm	79	158	50%	cbioportal
3	TTN	Ssm	67	158	42.4%	cbioportal
4	MUC16	Ssm	60	158	38%	cbioportal
5	AHNAK2	Ssm	56	158	35.4%	cbioportal
6	SETD2	Ssm	52	158	32.9%	cbioportal
7	OBSCN	Ssm	51	158	32.3%	cbioportal
8	HSPG2	Ssm	48	158	30.4%	cbioportal
9	KMT2D	Ssm	46	158	29.1%	cbioportal
10	LRP1	Ssm	45	158	28.5%	cbioportal
11	BSN	Ssm	44	158	27.8%	cbioportal
12	MUC5B	Ssm	44	158	27.8%	cbioportal
13	ZNF469	Ssm	41	158	25.9%	cbioportal
14	ZNF594	Ssm	40	158	25.3%	cbioportal
15	COL7A1	Ssm	39	158	24.7%	cbioportal
16	LAMA5	Ssm	39	158	24.7%	cbioportal
20	OTOG	Ssm	38	158	24.1%	cbioportal
17	AHNAK	Ssm	38	158	24.1%	cbioportal
18	FLNA	Ssm	38	158	24.1%	cbioportal
19	MUC5AC	Ssm	38	158	24.1%	cbioportal
21	PLEC	Ssm	38	158	24.1%	cbioportal
22	DNAH1	Ssm	37	158	23.4%	cbioportal
23	RYR1	Ssm	37	158	23.4%	cbioportal
24	SYNE1	Ssm	37	158	23.4%	cbioportal
25	IRF2BPL	Ssm	36	158	22.8%	cbioportal
26	KIF1A	Ssm	36	158	22.8%	cbioportal
27	PLXNB3	Ssm	36	158	22.8%	cbioportal
28	SPEG	Ssm	35	158	22.2%	cbioportal
30	CACNA1H	Ssm	34	158	21.5%	cbioportal
29	ADGRV1	Ssm	34	158	21.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-11

Renal Cell Carcinoma (St. James, Clin Cancer Res 2023) ccrcc_sjuh_2023St. James

943 cases with simple somatic mutation data · 943 cases total · 2026-03-09 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved12 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	642	943	68.1%	cbioportal
2	PBRM1	Ssm	325	943	34.5%	cbioportal
3	SETD2	Ssm	151	943	16%	cbioportal
4	BAP1	Ssm	119	943	12.6%	cbioportal
5	KDM5C	Ssm	67	943	7.1%	cbioportal
6	ATM	Ssm	31	943	3.3%	cbioportal
7	DMD	Ssm	29	943	3.1%	cbioportal
8	TP53	Ssm	29	943	3.1%	cbioportal
9	COL11A1	Ssm	21	943	2.2%	cbioportal
10	TRRAP	Ssm	12	943	1.3%	cbioportal
11	PTK7	Ssm	6	943	0.6%	cbioportal
12	ATP9B	Ssm	5	943	0.5%	cbioportal

Data updated 22 days agoSource updated 2026-03-09

Renal Clear Cell Carcinoma (TCGA GDC, 2025) ccrcc_tcga_gdcTCGA GDC

375 cases with simple somatic mutation data · 537 cases total · 2026-01-13 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	172	375	45.9%	cbioportal
2	PBRM1	Ssm	147	375	39.2%	cbioportal
3	TTN	Ssm	63	375	16.8%	cbioportal
4	SETD2	Ssm	46	375	12.3%	cbioportal
5	BAP1	Ssm	40	375	10.7%	cbioportal
6	MUC16	Ssm	29	375	7.7%	cbioportal
7	MTOR	Ssm	27	375	7.2%	cbioportal
8	KDM5C	Ssm	20	375	5.3%	cbioportal
10	DST	Ssm	19	375	5.1%	cbioportal
9	DNAH9	Ssm	19	375	5.1%	cbioportal
12	CSMD3	Ssm	17	375	4.5%	cbioportal
11	ATM	Ssm	17	375	4.5%	cbioportal
13	FBN2	Ssm	16	375	4.3%	cbioportal
16	LRP2	Ssm	16	375	4.3%	cbioportal
14	HMCN1	Ssm	16	375	4.3%	cbioportal
15	KMT2C	Ssm	16	375	4.3%	cbioportal
17	AHNAK2	Ssm	15	375	4%	cbioportal
20	SYNE1	Ssm	14	375	3.7%	cbioportal
18	ANK3	Ssm	14	375	3.7%	cbioportal
19	SPEN	Ssm	14	375	3.7%	cbioportal
21	USH2A	Ssm	14	375	3.7%	cbioportal
24	PCLO	Ssm	13	375	3.5%	cbioportal
22	DNAH2	Ssm	13	375	3.5%	cbioportal
23	MUC17	Ssm	13	375	3.5%	cbioportal
25	PTEN	Ssm	13	375	3.5%	cbioportal
29	PKHD1L1	Ssm	12	375	3.2%	cbioportal
26	ARID1A	Ssm	12	375	3.2%	cbioportal
27	FLG	Ssm	12	375	3.2%	cbioportal
28	LRP1B	Ssm	12	375	3.2%	cbioportal
30	XIRP2	Ssm	12	375	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Renal Clear Cell Carcinoma (UTokyo, Nat Genet 2013) ccrcc_utokyo_2013UTokyo

106 cases with simple somatic mutation data · 106 cases total · 2026-01-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	43	106	40.6%	cbioportal
2	PBRM1	Ssm	31	106	29.2%	cbioportal
3	TTN	Ssm	21	106	19.8%	cbioportal
4	MUC16	Ssm	15	106	14.2%	cbioportal
5	SETD2	Ssm	12	106	11.3%	cbioportal
6	BAP1	Ssm	9	106	8.5%	cbioportal
7	CSMD3	Ssm	8	106	7.5%	cbioportal
8	AHNAK2	Ssm	7	106	6.6%	cbioportal
11	KMT2C	Ssm	6	106	5.7%	cbioportal
14	TET2	Ssm	6	106	5.7%	cbioportal
13	MUC4	Ssm	6	106	5.7%	cbioportal
12	MTOR	Ssm	6	106	5.7%	cbioportal
10	HMCN1	Ssm	6	106	5.7%	cbioportal
9	FRYL	Ssm	6	106	5.7%	cbioportal
18	PIK3CA	Ssm	5	106	4.7%	cbioportal
19	PKHD1	Ssm	5	106	4.7%	cbioportal
20	ZNF536	Ssm	5	106	4.7%	cbioportal
15	ELOC	Ssm	5	106	4.7%	cbioportal
16	KCNMA1	Ssm	5	106	4.7%	cbioportal
17	KEAP1	Ssm	5	106	4.7%	cbioportal
26	DNAH3	Ssm	4	106	3.8%	cbioportal
27	EP300	Ssm	4	106	3.8%	cbioportal
28	GRB7	Ssm	4	106	3.8%	cbioportal
30	IQGAP2	Ssm	4	106	3.8%	cbioportal
29	HYDIN	Ssm	4	106	3.8%	cbioportal
21	ARHGEF28	Ssm	4	106	3.8%	cbioportal
22	BCL11A	Ssm	4	106	3.8%	cbioportal
23	CACNA1G	Ssm	4	106	3.8%	cbioportal
24	CUBN	Ssm	4	106	3.8%	cbioportal
25	DNAH11	Ssm	4	106	3.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Renal Non-Clear Cell Carcinoma (Genentech, Nat Genet 2014) nccrcc_genentech_2014Genentech

146 cases with simple somatic mutation data · 146 cases total · 2026-01-08 · mapped to Renal Non-Clear Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	17	146	11.6%	cbioportal
2	TP53	Ssm	11	146	7.5%	cbioportal
3	MET	Ssm	10	146	6.8%	cbioportal
4	MUC4	Ssm	9	146	6.2%	cbioportal
5	MACF1	Ssm	7	146	4.8%	cbioportal
6	PCLO	Ssm	7	146	4.8%	cbioportal
8	LRP2	Ssm	6	146	4.1%	cbioportal
7	ARID1A	Ssm	6	146	4.1%	cbioportal
9	SPEN	Ssm	6	146	4.1%	cbioportal
13	MUC6	Ssm	5	146	3.4%	cbioportal
10	FREM2	Ssm	5	146	3.4%	cbioportal
11	KMT2C	Ssm	5	146	3.4%	cbioportal
12	MUC16	Ssm	5	146	3.4%	cbioportal
14	OBSCN	Ssm	5	146	3.4%	cbioportal
15	PTEN	Ssm	5	146	3.4%	cbioportal
16	SETD2	Ssm	5	146	3.4%	cbioportal
17	STARD9	Ssm	5	146	3.4%	cbioportal
30	FAT2	Ssm	4	146	2.7%	cbioportal
18	ADGRV1	Ssm	4	146	2.7%	cbioportal
19	AHNAK	Ssm	4	146	2.7%	cbioportal
20	ANK3	Ssm	4	146	2.7%	cbioportal
21	APC	Ssm	4	146	2.7%	cbioportal
22	ARID1B	Ssm	4	146	2.7%	cbioportal
23	BIRC6	Ssm	4	146	2.7%	cbioportal
24	BLTP1	Ssm	4	146	2.7%	cbioportal
25	CACNA1C	Ssm	4	146	2.7%	cbioportal
26	CEP295	Ssm	4	146	2.7%	cbioportal
27	CUBN	Ssm	4	146	2.7%	cbioportal
28	DNAH5	Ssm	4	146	2.7%	cbioportal
29	ERCC2	Ssm	4	146	2.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Small Cell Carcinoma of the Ovary (MSK, Nat Genet 2014) scco_mskccMSK

12 cases with simple somatic mutation data · 12 cases total · 2026-01-13 · mapped to Ovarian Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved5 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMARCA4	Ssm	11	12	91.7%	cbioportal
2	ASXL1	Ssm	1	12	8.3%	cbioportal
3	JAK3	Ssm	1	12	8.3%	cbioportal
4	NOTCH2	Ssm	1	12	8.3%	cbioportal
5	WT1	Ssm	1	12	8.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Squamous Cell Carcinoma of the Vulva (CUK, Exp Mol Med 2018) vsc_cuk_2018CUK

15 cases with simple somatic mutation data · 15 cases total · 2026-01-16 · mapped to Vaginal Squamous Cell Carcinoma, Not Otherwise Specified EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MAML2	Ssm	6	15	40%	cbioportal
4	SYNE1	Ssm	5	15	33.3%	cbioportal
5	TP53	Ssm	5	15	33.3%	cbioportal
2	ODF1	Ssm	5	15	33.3%	cbioportal
3	SPTBN1	Ssm	5	15	33.3%	cbioportal
6	FAT2	Ssm	4	15	26.7%	cbioportal
7	NRG3	Ssm	4	15	26.7%	cbioportal
25	MDN1	Ssm	3	15	20%	cbioportal
31	SLC12A3	Ssm	3	15	20%	cbioportal
32	ZBTB41	Ssm	3	15	20%	cbioportal
33	ZFHX3	Ssm	3	15	20%	cbioportal
34	ZNF385B	Ssm	3	15	20%	cbioportal
35	ZNF518B	Ssm	3	15	20%	cbioportal
8	AHNAK	Ssm	3	15	20%	cbioportal
9	ALMS1	Ssm	3	15	20%	cbioportal
10	AMOTL2	Ssm	3	15	20%	cbioportal
11	ANP32E	Ssm	3	15	20%	cbioportal
12	APC	Ssm	3	15	20%	cbioportal
13	CACNA1B	Ssm	3	15	20%	cbioportal
14	CASP8	Ssm	3	15	20%	cbioportal
15	CREBBP	Ssm	3	15	20%	cbioportal
16	CSMD1	Ssm	3	15	20%	cbioportal
17	DCHS1	Ssm	3	15	20%	cbioportal
18	F5	Ssm	3	15	20%	cbioportal
19	FAM193A	Ssm	3	15	20%	cbioportal
20	FAT1	Ssm	3	15	20%	cbioportal
21	KMT2B	Ssm	3	15	20%	cbioportal
22	KMT2C	Ssm	3	15	20%	cbioportal
24	MAML3	Ssm	3	15	20%	cbioportal
23	LAMA5	Ssm	3	15	20%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Unclassified Renal Cell Carcinoma (MSK, Nature 2016) urcc_mskcc_2016MSK

62 cases with simple somatic mutation data · 62 cases total · 2026-01-16 · mapped to Unclassified Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	SETD2	Ssm	11	62	17.7%	cbioportal
1	NF2	Ssm	11	62	17.7%	cbioportal
3	BAP1	Ssm	8	62	12.9%	cbioportal
4	KMT2C	Ssm	6	62	9.7%	cbioportal
5	MTOR	Ssm	5	62	8.1%	cbioportal
6	ATRX	Ssm	4	62	6.5%	cbioportal
7	PTEN	Ssm	4	62	6.5%	cbioportal
8	TSC1	Ssm	4	62	6.5%	cbioportal
16	TSC2	Ssm	3	62	4.8%	cbioportal
9	DNMT3A	Ssm	3	62	4.8%	cbioportal
10	FH	Ssm	3	62	4.8%	cbioportal
11	KLF6	Ssm	3	62	4.8%	cbioportal
12	KMT2D	Ssm	3	62	4.8%	cbioportal
13	NOTCH2	Ssm	3	62	4.8%	cbioportal
14	SMARCB1	Ssm	3	62	4.8%	cbioportal
15	TP53	Ssm	3	62	4.8%	cbioportal
19	GNAS	Ssm	2	62	3.2%	cbioportal
17	CHEK2	Ssm	2	62	3.2%	cbioportal
18	EPHA6	Ssm	2	62	3.2%	cbioportal
20	IRS1	Ssm	2	62	3.2%	cbioportal
21	KDM6A	Ssm	2	62	3.2%	cbioportal
22	KMT2A	Ssm	2	62	3.2%	cbioportal
23	MLST8	Ssm	2	62	3.2%	cbioportal
24	PBRM1	Ssm	2	62	3.2%	cbioportal
25	PRKN	Ssm	2	62	3.2%	cbioportal
26	RICTOR	Ssm	2	62	3.2%	cbioportal
27	RPTOR	Ssm	2	62	3.2%	cbioportal
28	SUFU	Ssm	2	62	3.2%	cbioportal
29	ABL1	Ssm	1	62	1.6%	cbioportal
30	ABL2	Ssm	1	62	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Upper Tract Urothelial Cancer (MSK, Eur Urol 2015) utuc_mskcc_2015MSK

85 cases with simple somatic mutation data · 85 cases total · 2026-01-16 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FGFR3	Ssm	41	85	48.2%	cbioportal
2	KMT2D	Ssm	30	85	35.3%	cbioportal
3	KDM6A	Ssm	29	85	34.1%	cbioportal
4	KMT2C	Ssm	22	85	25.9%	cbioportal
5	STAG2	Ssm	19	85	22.4%	cbioportal
7	TP53	Ssm	15	85	17.6%	cbioportal
6	CREBBP	Ssm	15	85	17.6%	cbioportal
8	TSC1	Ssm	14	85	16.5%	cbioportal
9	PIK3CA	Ssm	13	85	15.3%	cbioportal
10	ARID1A	Ssm	11	85	12.9%	cbioportal
11	ATM	Ssm	10	85	11.8%	cbioportal
12	TERT	Ssm	10	85	11.8%	cbioportal
14	SMARCA4	Ssm	9	85	10.6%	cbioportal
13	HRAS	Ssm	9	85	10.6%	cbioportal
16	FAT1	Ssm	8	85	9.4%	cbioportal
15	EP300	Ssm	8	85	9.4%	cbioportal
18	EPHA5	Ssm	7	85	8.2%	cbioportal
17	ARID2	Ssm	7	85	8.2%	cbioportal
20	FBXW7	Ssm	6	85	7.1%	cbioportal
22	PBRM1	Ssm	6	85	7.1%	cbioportal
21	NF1	Ssm	6	85	7.1%	cbioportal
19	ERBB2	Ssm	6	85	7.1%	cbioportal
26	GRIN2A	Ssm	5	85	5.9%	cbioportal
27	INPP4A	Ssm	5	85	5.9%	cbioportal
30	NOTCH1	Ssm	5	85	5.9%	cbioportal
29	MTOR	Ssm	5	85	5.9%	cbioportal
28	MET	Ssm	5	85	5.9%	cbioportal
23	ARID1B	Ssm	5	85	5.9%	cbioportal
24	CDKN1A	Ssm	5	85	5.9%	cbioportal
25	CDKN2A	Ssm	5	85	5.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Upper Tract Urothelial Carcinoma (Cornell/Baylor/MDACC, Nat Commun 2019) utuc_cornell_baylor_mdacc_2019Cornell/Baylor/MDACC

37 cases with simple somatic mutation data · 47 cases total · 2026-01-19 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	13	37	35.1%	cbioportal
2	TP53	Ssm	12	37	32.4%	cbioportal
3	FGFR3	Ssm	11	37	29.7%	cbioportal
4	PIK3CA	Ssm	8	37	21.6%	cbioportal
5	ATM	Ssm	7	37	18.9%	cbioportal
8	EYS	Ssm	5	37	13.5%	cbioportal
7	CDKN1A	Ssm	5	37	13.5%	cbioportal
6	ADGRV1	Ssm	5	37	13.5%	cbioportal
9	OBSCN	Ssm	5	37	13.5%	cbioportal
18	TTN	Ssm	4	37	10.8%	cbioportal
20	ZFHX4	Ssm	4	37	10.8%	cbioportal
10	AFF1	Ssm	4	37	10.8%	cbioportal
11	ARID1A	Ssm	4	37	10.8%	cbioportal
12	KDM6A	Ssm	4	37	10.8%	cbioportal
13	MACF1	Ssm	4	37	10.8%	cbioportal
14	MUC17	Ssm	4	37	10.8%	cbioportal
15	PLXNA2	Ssm	4	37	10.8%	cbioportal
16	RNF213	Ssm	4	37	10.8%	cbioportal
17	SPTAN1	Ssm	4	37	10.8%	cbioportal
19	UTRN	Ssm	4	37	10.8%	cbioportal
25	ATG2A	Ssm	3	37	8.1%	cbioportal
24	ARK2N	Ssm	3	37	8.1%	cbioportal
23	AHNAK	Ssm	3	37	8.1%	cbioportal
21	ABCC1	Ssm	3	37	8.1%	cbioportal
22	AHCTF1	Ssm	3	37	8.1%	cbioportal
26	ATP2B2	Ssm	3	37	8.1%	cbioportal
30	BIRC6	Ssm	3	37	8.1%	cbioportal
29	BICD2	Ssm	3	37	8.1%	cbioportal
28	BAP1	Ssm	3	37	8.1%	cbioportal
27	ATR	Ssm	3	37	8.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Upper Tract Urothelial Carcinoma (IGBMC, Genome Biology 2021) utuc_igbmc_2021IGBMC

30 cases with simple somatic mutation data · 30 cases total · 2026-01-19 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FGFR3	Ssm	15	30	50%	cbioportal
2	TTN	Ssm	9	30	30%	cbioportal
3	KDM6A	Ssm	8	30	26.7%	cbioportal
4	KMT2D	Ssm	8	30	26.7%	cbioportal
5	KMT2C	Ssm	7	30	23.3%	cbioportal
6	MUC4	Ssm	7	30	23.3%	cbioportal
8	ZFP36L1	Ssm	6	30	20%	cbioportal
7	HYDIN	Ssm	6	30	20%	cbioportal
11	STAG2	Ssm	5	30	16.7%	cbioportal
9	ARID1A	Ssm	5	30	16.7%	cbioportal
10	CELSR1	Ssm	5	30	16.7%	cbioportal
12	TP53	Ssm	5	30	16.7%	cbioportal
18	MUC16	Ssm	4	30	13.3%	cbioportal
19	ZNF469	Ssm	4	30	13.3%	cbioportal
17	HECTD4	Ssm	4	30	13.3%	cbioportal
16	GANAB	Ssm	4	30	13.3%	cbioportal
15	EP300	Ssm	4	30	13.3%	cbioportal
14	CRIPAK	Ssm	4	30	13.3%	cbioportal
13	ACACA	Ssm	4	30	13.3%	cbioportal
29	DNAH17	Ssm	3	30	10%	cbioportal
30	DOCK4	Ssm	3	30	10%	cbioportal
22	BSN	Ssm	3	30	10%	cbioportal
21	BRWD1	Ssm	3	30	10%	cbioportal
20	ADCY10	Ssm	3	30	10%	cbioportal
28	DNAH11	Ssm	3	30	10%	cbioportal
24	CDK13	Ssm	3	30	10%	cbioportal
25	CNTNAP4	Ssm	3	30	10%	cbioportal
26	COG2	Ssm	3	30	10%	cbioportal
27	CSMD3	Ssm	3	30	10%	cbioportal
23	CDK12	Ssm	3	30	10%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Upper Tract Urothelial Carcinoma (MSK, Nat Commun 2020) utuc_msk_2019MSK

119 cases with simple somatic mutation data · 119 cases total · 2026-01-16 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FGFR3	Ssm	55	119	46.2%	cbioportal
2	KMT2D	Ssm	41	119	34.5%	cbioportal
3	KDM6A	Ssm	39	119	32.8%	cbioportal
4	TERT	Ssm	32	119	26.9%	cbioportal
5	KMT2C	Ssm	27	119	22.7%	cbioportal
7	TP53	Ssm	26	119	21.8%	cbioportal
6	ARID1A	Ssm	26	119	21.8%	cbioportal
8	STAG2	Ssm	24	119	20.2%	cbioportal
9	CREBBP	Ssm	21	119	17.6%	cbioportal
10	ATM	Ssm	19	119	16%	cbioportal
11	PIK3CA	Ssm	19	119	16%	cbioportal
12	TSC1	Ssm	16	119	13.4%	cbioportal
13	HRAS	Ssm	14	119	11.8%	cbioportal
45	ZFHX3	Ssm	7	60	11.7%	cbioportal
14	SMARCA4	Ssm	13	119	10.9%	cbioportal
15	ARID1B	Ssm	11	119	9.2%	cbioportal
19	FBXW7	Ssm	11	119	9.2%	cbioportal
18	FAT1	Ssm	11	119	9.2%	cbioportal
16	EP300	Ssm	11	119	9.2%	cbioportal
17	ERBB2	Ssm	11	119	9.2%	cbioportal
21	PBRM1	Ssm	10	119	8.4%	cbioportal
20	NF1	Ssm	10	119	8.4%	cbioportal
81	SPEN	Ssm	5	61	8.2%	cbioportal
22	CDKN1A	Ssm	9	119	7.6%	cbioportal
25	MTOR	Ssm	9	119	7.6%	cbioportal
24	MET	Ssm	9	119	7.6%	cbioportal
23	EPHA5	Ssm	9	119	7.6%	cbioportal
26	ARID2	Ssm	8	119	6.7%	cbioportal
28	CTCF	Ssm	8	119	6.7%	cbioportal
29	KRAS	Ssm	8	119	6.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Upper Tract Urothelial Carcinoma PDX (MSK, Nat Commun 2020) utuc_pdx_msk_2019MSK

78 cases with simple somatic mutation data · 78 cases total · 2026-01-16 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	37	78	47.4%	cbioportal
2	ARID1A	Ssm	29	78	37.2%	cbioportal
3	FGFR3	Ssm	28	78	35.9%	cbioportal
4	TP53	Ssm	27	78	34.6%	cbioportal
5	KMT2D	Ssm	25	78	32.1%	cbioportal
6	KDM6A	Ssm	24	78	30.8%	cbioportal
7	ATM	Ssm	19	78	24.4%	cbioportal
8	CREBBP	Ssm	17	78	21.8%	cbioportal
9	ZFHX3	Ssm	15	70	21.4%	cbioportal
10	SMARCA4	Ssm	14	78	17.9%	cbioportal
13	MDC1	Ssm	13	76	17.1%	cbioportal
99	MSH3	Ssm	5	30	16.7%	cbioportal
12	EP300	Ssm	13	78	16.7%	cbioportal
11	ASXL1	Ssm	13	78	16.7%	cbioportal
16	PIK3CA	Ssm	12	78	15.4%	cbioportal
15	MSH2	Ssm	12	78	15.4%	cbioportal
17	SETD2	Ssm	12	78	15.4%	cbioportal
14	BRCA1	Ssm	12	78	15.4%	cbioportal
18	NOTCH2	Ssm	11	78	14.1%	cbioportal
29	RECQL4	Ssm	10	76	13.2%	cbioportal
24	DNMT3A	Ssm	10	78	12.8%	cbioportal
23	DNMT1	Ssm	10	78	12.8%	cbioportal
21	CDKN1A	Ssm	10	78	12.8%	cbioportal
25	FAT1	Ssm	10	78	12.8%	cbioportal
26	HRAS	Ssm	10	78	12.8%	cbioportal
27	MET	Ssm	10	78	12.8%	cbioportal
28	PIK3CB	Ssm	10	78	12.8%	cbioportal
22	CTCF	Ssm	10	78	12.8%	cbioportal
20	BCOR	Ssm	10	78	12.8%	cbioportal
19	ARID1B	Ssm	10	78	12.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Urothelial Cancer Patient Derived Organoids (MSK, 2025) blca_pdx_msk_2025MSK

90 cases with simple somatic mutation data · 90 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	71	90	78.9%	cbioportal
3	KDM6A	Ssm	35	90	38.9%	cbioportal
2	FGFR3	Ssm	35	90	38.9%	cbioportal
4	TP53	Ssm	34	90	37.8%	cbioportal
24	USP8	Ssm	12	34	35.3%	cbioportal
5	KMT2D	Ssm	31	90	34.4%	cbioportal
28	HLA-B	Ssm	11	46	23.9%	cbioportal
58	SERPINB3	Ssm	8	34	23.5%	cbioportal
6	MDC1	Ssm	21	90	23.3%	cbioportal
7	ARID1A	Ssm	20	90	22.2%	cbioportal
8	KMT2C	Ssm	19	90	21.1%	cbioportal
9	CREBBP	Ssm	18	90	20%	cbioportal
11	TSC1	Ssm	18	90	20%	cbioportal
10	PIK3CA	Ssm	18	90	20%	cbioportal
12	ZFHX3	Ssm	17	88	19.3%	cbioportal
13	ATM	Ssm	16	90	17.8%	cbioportal
102	SERPINB4	Ssm	6	34	17.6%	cbioportal
74	ATXN7	Ssm	6	34	17.6%	cbioportal
14	BRCA2	Ssm	15	90	16.7%	cbioportal
16	SPEN	Ssm	14	90	15.6%	cbioportal
15	ATR	Ssm	14	90	15.6%	cbioportal
71	PREX2	Ssm	7	46	15.2%	cbioportal
112	HLA-C	Ssm	5	34	14.7%	cbioportal
126	SMARCA2	Ssm	5	34	14.7%	cbioportal
17	STAG2	Ssm	13	90	14.4%	cbioportal
23	ROS1	Ssm	12	90	13.3%	cbioportal
22	PALB2	Ssm	12	90	13.3%	cbioportal
21	NOTCH3	Ssm	12	90	13.3%	cbioportal
20	NF1	Ssm	12	90	13.3%	cbioportal
19	FAT1	Ssm	12	90	13.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Urothelial Carcinoma (BCAN/HCRN, Nat Commun 2022) blca_bcan_hcrn_2022BCAN/HCRN

192 cases with simple somatic mutation data · 192 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	108	192	56.3%	cbioportal
2	KMT2D	Ssm	62	192	32.3%	cbioportal
3	ARID1A	Ssm	55	192	28.6%	cbioportal
4	RNF213	Ssm	54	192	28.1%	cbioportal
5	KDM6A	Ssm	48	192	25%	cbioportal
6	LRP1B	Ssm	47	192	24.5%	cbioportal
7	AKAP9	Ssm	39	192	20.3%	cbioportal
8	SPEN	Ssm	38	192	19.8%	cbioportal
9	BRCA2	Ssm	37	192	19.3%	cbioportal
10	KMT2C	Ssm	35	192	18.2%	cbioportal
11	EP300	Ssm	34	192	17.7%	cbioportal
12	FGFR3	Ssm	34	192	17.7%	cbioportal
13	RB1	Ssm	32	192	16.7%	cbioportal
15	PRKDC	Ssm	31	192	16.1%	cbioportal
14	ATM	Ssm	31	192	16.1%	cbioportal
16	KMT2A	Ssm	30	192	15.6%	cbioportal
18	PDE4DIP	Ssm	29	192	15.1%	cbioportal
19	PIK3CA	Ssm	29	192	15.1%	cbioportal
17	CREBBP	Ssm	29	192	15.1%	cbioportal
21	PCM1	Ssm	26	192	13.5%	cbioportal
20	KIAA1549	Ssm	26	192	13.5%	cbioportal
26	RECQL4	Ssm	25	192	13%	cbioportal
25	NOTCH1	Ssm	25	192	13%	cbioportal
24	MYH9	Ssm	25	192	13%	cbioportal
23	KNL1	Ssm	25	192	13%	cbioportal
22	FANCA	Ssm	25	192	13%	cbioportal
27	ERBB3	Ssm	24	192	12.5%	cbioportal
28	ERCC2	Ssm	23	192	12%	cbioportal
29	CNTRL	Ssm	22	192	11.5%	cbioportal
30	TRIP11	Ssm	22	192	11.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Urothelial Carcinoma (Cornell/Trento, Nat Gen 2016) blca_cornell_2016Cornell/Trento

72 cases with simple somatic mutation data · 72 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	41	72	56.9%	cbioportal
2	TTN	Ssm	26	72	36.1%	cbioportal
4	RYR2	Ssm	19	72	26.4%	cbioportal
3	MUC16	Ssm	19	72	26.4%	cbioportal
5	KMT2D	Ssm	17	72	23.6%	cbioportal
6	MDC1	Ssm	17	72	23.6%	cbioportal
7	MYLK	Ssm	17	72	23.6%	cbioportal
8	ZNF729	Ssm	17	72	23.6%	cbioportal
9	DLG2	Ssm	16	72	22.2%	cbioportal
10	MBD4	Ssm	16	72	22.2%	cbioportal
11	MTCL2	Ssm	16	72	22.2%	cbioportal
12	NIN	Ssm	16	72	22.2%	cbioportal
13	PEAK1	Ssm	16	72	22.2%	cbioportal
14	CTCF	Ssm	15	72	20.8%	cbioportal
15	DYNC1H1	Ssm	15	72	20.8%	cbioportal
16	NOM1	Ssm	15	72	20.8%	cbioportal
17	PCF11	Ssm	15	72	20.8%	cbioportal
18	TCHH	Ssm	15	72	20.8%	cbioportal
19	USP48	Ssm	15	72	20.8%	cbioportal
20	BICRA	Ssm	14	72	19.4%	cbioportal
21	IFIH1	Ssm	14	72	19.4%	cbioportal
22	LATS1	Ssm	14	72	19.4%	cbioportal
23	LRWD1	Ssm	14	72	19.4%	cbioportal
24	MLXIPL	Ssm	14	72	19.4%	cbioportal
25	NCOA3	Ssm	14	72	19.4%	cbioportal
26	PDCL	Ssm	14	72	19.4%	cbioportal
27	PXDN	Ssm	14	72	19.4%	cbioportal
28	SPTAN1	Ssm	14	72	19.4%	cbioportal
29	SYNE2	Ssm	14	72	19.4%	cbioportal
30	ACE	Ssm	13	72	18.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Uterine Carcinosarcoma (Johns Hopkins, Nat Commun 2014) ucs_jhu_2014Johns Hopkins

22 cases with simple somatic mutation data · 22 cases total · 2026-01-16 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	16	22	72.7%	cbioportal
3	PTEN	Ssm	9	22	40.9%	cbioportal
2	PIK3CA	Ssm	9	22	40.9%	cbioportal
4	ARID1A	Ssm	8	22	36.4%	cbioportal
7	PXDNL	Ssm	6	22	27.3%	cbioportal
5	KMT2C	Ssm	6	22	27.3%	cbioportal
6	KRAS	Ssm	6	22	27.3%	cbioportal
8	TTN	Ssm	6	22	27.3%	cbioportal
13	CNTNAP2	Ssm	5	22	22.7%	cbioportal
9	APOB	Ssm	5	22	22.7%	cbioportal
10	BCOR	Ssm	5	22	22.7%	cbioportal
11	BLTP1	Ssm	5	22	22.7%	cbioportal
12	CDHR3	Ssm	5	22	22.7%	cbioportal
24	URB1	Ssm	5	22	22.7%	cbioportal
14	FAM135B	Ssm	5	22	22.7%	cbioportal
16	HMCN1	Ssm	5	22	22.7%	cbioportal
15	FBXW7	Ssm	5	22	22.7%	cbioportal
17	LRP2	Ssm	5	22	22.7%	cbioportal
18	LTBP2	Ssm	5	22	22.7%	cbioportal
19	MDN1	Ssm	5	22	22.7%	cbioportal
20	PLEC	Ssm	5	22	22.7%	cbioportal
21	SPEG	Ssm	5	22	22.7%	cbioportal
22	SPTBN5	Ssm	5	22	22.7%	cbioportal
23	TRRAP	Ssm	5	22	22.7%	cbioportal
85	FNDC1	Ssm	4	22	18.2%	cbioportal
84	FLNA	Ssm	4	22	18.2%	cbioportal
83	FGA	Ssm	4	22	18.2%	cbioportal
82	FAT4	Ssm	4	22	18.2%	cbioportal
81	FAT1	Ssm	4	22	18.2%	cbioportal
86	FRMPD1	Ssm	4	22	18.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Uterine Carcinosarcoma (TCGA, Firehose Legacy) ucs_tcgaTCGA

57 cases with simple somatic mutation data · 57 cases total · 2026-01-13 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	FRG1BP	Ssm	21	57	36.8%	cbioportal
4	PIK3CA	Ssm	20	57	35.1%	cbioportal
5	PPP2R1A	Ssm	16	57	28.1%	cbioportal
6	MUC4	Ssm	13	57	22.8%	cbioportal
7	PTEN	Ssm	11	57	19.3%	cbioportal
9	TTN	Ssm	10	57	17.5%	cbioportal
8	CHD4	Ssm	10	57	17.5%	cbioportal
10	ARID1A	Ssm	8	57	14%	cbioportal
13	MUC17	Ssm	7	57	12.3%	cbioportal
12	LRP1B	Ssm	7	57	12.3%	cbioportal
11	KRAS	Ssm	7	57	12.3%	cbioportal
23	ZBTB7B	Ssm	6	57	10.5%	cbioportal
14	ARHGAP35	Ssm	6	57	10.5%	cbioportal
15	FLNA	Ssm	6	57	10.5%	cbioportal
16	KMT2D	Ssm	6	57	10.5%	cbioportal
17	MGAM	Ssm	6	57	10.5%	cbioportal
18	MUC16	Ssm	6	57	10.5%	cbioportal
19	PIK3R1	Ssm	6	57	10.5%	cbioportal
20	RB1	Ssm	6	57	10.5%	cbioportal
21	SYNE1	Ssm	6	57	10.5%	cbioportal
22	VPS13B	Ssm	6	57	10.5%	cbioportal
24	ZNF814	Ssm	6	57	10.5%	cbioportal
26	DOP1A	Ssm	5	57	8.8%	cbioportal
29	FLG	Ssm	5	57	8.8%	cbioportal
25	ATP4A	Ssm	5	57	8.8%	cbioportal
30	LRP2	Ssm	5	57	8.8%	cbioportal
27	FCGBP	Ssm	5	57	8.8%	cbioportal
28	FER1L6	Ssm	5	57	8.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Carcinosarcoma (TCGA, PanCancer Atlas) ucs_tcga_pan_can_atlas_2018TCGA

57 cases with simple somatic mutation data · 57 cases total · 2026-06-05 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	52	57	91.2%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	PIK3CA	Ssm	20	57	35.1%	cbioportal
4	PPP2R1A	Ssm	16	57	28.1%	cbioportal
5	PTEN	Ssm	11	57	19.3%	cbioportal
6	TTN	Ssm	11	57	19.3%	cbioportal
7	CHD4	Ssm	10	57	17.5%	cbioportal
9	KRAS	Ssm	7	57	12.3%	cbioportal
8	ARID1A	Ssm	7	57	12.3%	cbioportal
16	PIK3R1	Ssm	6	57	10.5%	cbioportal
14	MGAM	Ssm	6	57	10.5%	cbioportal
13	KMT2D	Ssm	6	57	10.5%	cbioportal
12	FLNA	Ssm	6	57	10.5%	cbioportal
11	ARHGAP35	Ssm	6	57	10.5%	cbioportal
10	AHNAK	Ssm	6	57	10.5%	cbioportal
19	ZBTB7B	Ssm	6	57	10.5%	cbioportal
18	VPS13B	Ssm	6	57	10.5%	cbioportal
17	SYNE1	Ssm	6	57	10.5%	cbioportal
15	MUC16	Ssm	6	57	10.5%	cbioportal
21	FER1L6	Ssm	5	57	8.8%	cbioportal
20	DOP1A	Ssm	5	57	8.8%	cbioportal
22	FLG	Ssm	5	57	8.8%	cbioportal
23	LRP1B	Ssm	5	57	8.8%	cbioportal
24	LRP2	Ssm	5	57	8.8%	cbioportal
25	MUC17	Ssm	5	57	8.8%	cbioportal
26	RB1	Ssm	5	57	8.8%	cbioportal
29	BRWD1	Ssm	4	57	7%	cbioportal
28	ADAMTSL1	Ssm	4	57	7%	cbioportal
27	ABCA12	Ssm	4	57	7%	cbioportal
46	MED12	Ssm	4	57	7%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Uterine Carcinosarcoma/Uterine Malignant Mixed Mullerian Tumor (TCGA GDC, 2025) ucs_tcga_gdcTCGA GDC

57 cases with simple somatic mutation data · 57 cases total · 2026-01-14 · mapped to Uterine Malignant Mixed Mesodermal (Mullerian) Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	49	57	86%	cbioportal
2	FBXW7	Ssm	22	57	38.6%	cbioportal
3	PIK3CA	Ssm	20	57	35.1%	cbioportal
4	PPP2R1A	Ssm	16	57	28.1%	cbioportal
5	PTEN	Ssm	11	57	19.3%	cbioportal
6	CHD4	Ssm	10	57	17.5%	cbioportal
7	PIK3R1	Ssm	9	57	15.8%	cbioportal
8	ARID1A	Ssm	7	57	12.3%	cbioportal
10	TTN	Ssm	7	57	12.3%	cbioportal
9	KRAS	Ssm	7	57	12.3%	cbioportal
12	ARHGAP35	Ssm	6	57	10.5%	cbioportal
11	AHNAK	Ssm	6	57	10.5%	cbioportal
18	ZBTB7B	Ssm	6	57	10.5%	cbioportal
17	SYNE1	Ssm	6	57	10.5%	cbioportal
16	MGAM	Ssm	6	57	10.5%	cbioportal
15	LRP2	Ssm	6	57	10.5%	cbioportal
14	KMT2D	Ssm	6	57	10.5%	cbioportal
13	FLNA	Ssm	6	57	10.5%	cbioportal
21	MUC17	Ssm	5	57	8.8%	cbioportal
19	DOP1A	Ssm	5	57	8.8%	cbioportal
23	VPS13B	Ssm	5	57	8.8%	cbioportal
22	RB1	Ssm	5	57	8.8%	cbioportal
20	MUC16	Ssm	5	57	8.8%	cbioportal
24	ABCA12	Ssm	4	57	7%	cbioportal
30	DPP10	Ssm	4	57	7%	cbioportal
29	DNAH2	Ssm	4	57	7%	cbioportal
28	CUBN	Ssm	4	57	7%	cbioportal
27	COPB1	Ssm	4	57	7%	cbioportal
26	BRWD1	Ssm	4	57	7%	cbioportal
25	ADAMTSL1	Ssm	4	57	7%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Uterine Clear Cell Carcinoma (NIH, Cancer 2017) uccc_nih_2017NIH

16 cases with simple somatic mutation data · 16 cases total · 2026-01-13 · mapped to Human Papillomavirus-Independent Cervical Adenocarcinoma, Clear Cell-Type EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	7	16	43.8%	cbioportal
2	KMT2C	Ssm	5	16	31.3%	cbioportal
3	TAF1	Ssm	4	16	25%	cbioportal
4	ZNF717	Ssm	4	16	25%	cbioportal
6	FAM136A	Ssm	3	16	18.8%	cbioportal
5	AGAP4	Ssm	3	16	18.8%	cbioportal
7	PIK3CA	Ssm	3	16	18.8%	cbioportal
23	DYSF	Ssm	2	16	12.5%	cbioportal
25	ERBB3	Ssm	2	16	12.5%	cbioportal
9	AHNAK2	Ssm	2	16	12.5%	cbioportal
10	AP3D1	Ssm	2	16	12.5%	cbioportal
11	ARID1A	Ssm	2	16	12.5%	cbioportal
12	ASTE1	Ssm	2	16	12.5%	cbioportal
13	CCDC178	Ssm	2	16	12.5%	cbioportal
14	CHL1	Ssm	2	16	12.5%	cbioportal
15	CHRM5	Ssm	2	16	12.5%	cbioportal
16	COIL	Ssm	2	16	12.5%	cbioportal
17	COL5A1	Ssm	2	16	12.5%	cbioportal
18	DENND4A	Ssm	2	16	12.5%	cbioportal
19	DMAP1	Ssm	2	16	12.5%	cbioportal
20	DNAH11	Ssm	2	16	12.5%	cbioportal
21	DNAH3	Ssm	2	16	12.5%	cbioportal
22	DST	Ssm	2	16	12.5%	cbioportal
27	FOXA2	Ssm	2	16	12.5%	cbioportal
28	FRG1	Ssm	2	16	12.5%	cbioportal
29	FRG2C	Ssm	2	16	12.5%	cbioportal
30	GART	Ssm	2	16	12.5%	cbioportal
8	ABCD1	Ssm	2	16	12.5%	cbioportal
24	EPC2	Ssm	2	16	12.5%	cbioportal
26	FAT3	Ssm	2	16	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Corpus Endometrial Carcinoma TCGA-UCECTCGA

559 cases with simple somatic mutation data · 560 cases total · Data Release 46.0 · mapped to Endometrial Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	418	559	74.8%	gdc
2	PIK3CA	Ssm	349	559	62.4%	gdc
3	ARID1A	Ssm	319	559	57.1%	gdc
4	TTN	Ssm	297	559	53.1%	gdc
5	OBSCN	Ssm	296	559	53%	gdc
6	RYR2	Ssm	291	559	52.1%	gdc
7	ASH1L	Ssm	289	559	51.7%	gdc
8	USH2A	Ssm	286	559	51.2%	gdc
9	FLG	Ssm	283	559	50.6%	gdc
10	CACNA1E	Ssm	281	559	50.3%	gdc
11	HMCN1	Ssm	278	559	49.7%	gdc
13	HRNR	Ssm	277	559	49.6%	gdc
14	CEP350	Ssm	277	559	49.6%	gdc
12	CSMD3	Ssm	277	559	49.6%	gdc
15	CTCF	Ssm	276	559	49.4%	gdc
16	GON4L	Ssm	275	559	49.2%	gdc
18	ZFHX3	Ssm	275	559	49.2%	gdc
17	ASPM	Ssm	275	559	49.2%	gdc
19	NFASC	Ssm	271	559	48.5%	gdc
20	CSMD1	Ssm	270	559	48.3%	gdc
21	PDE4DIP	Ssm	269	559	48.1%	gdc
22	SPTA1	Ssm	269	559	48.1%	gdc
23	INSRR	Ssm	269	559	48.1%	gdc
24	SETDB1	Ssm	267	559	47.8%	gdc
25	F5	Ssm	266	559	47.6%	gdc
26	MUC16	Ssm	266	559	47.6%	gdc
27	COPA	Ssm	266	559	47.6%	gdc
28	PRRC2C	Ssm	265	559	47.4%	gdc
29	ARHGEF2	Ssm	265	559	47.4%	gdc
30	LYST	Ssm	264	559	47.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Uterine Corpus Endometrial Carcinoma (TCGA, Firehose Legacy) ucec_tcgaTCGA

248 cases with simple somatic mutation data · 549 cases total · 2026-01-13 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	161	248	64.9%	cbioportal
2	PIK3CA	Ssm	132	248	53.2%	cbioportal
3	ARID1A	Ssm	83	248	33.5%	cbioportal
4	PIK3R1	Ssm	82	248	33.1%	cbioportal
5	TTN	Ssm	79	248	31.9%	cbioportal
6	CTNNB1	Ssm	74	248	29.8%	cbioportal
7	TP53	Ssm	69	248	27.8%	cbioportal
8	KRAS	Ssm	52	248	21%	cbioportal
9	MUC16	Ssm	48	248	19.4%	cbioportal
10	CSMD3	Ssm	47	248	19%	cbioportal
11	CTCF	Ssm	45	248	18.1%	cbioportal
12	ZFHX3	Ssm	44	248	17.7%	cbioportal
13	MUC5B	Ssm	43	248	17.3%	cbioportal
14	RYR2	Ssm	41	248	16.5%	cbioportal
16	FAT4	Ssm	40	248	16.1%	cbioportal
15	FAT1	Ssm	40	248	16.1%	cbioportal
17	OBSCN	Ssm	39	248	15.7%	cbioportal
18	DMD	Ssm	38	248	15.3%	cbioportal
19	FBXW7	Ssm	38	248	15.3%	cbioportal
20	NEB	Ssm	37	248	14.9%	cbioportal
23	ZFHX4	Ssm	36	248	14.5%	cbioportal
21	ARHGAP35	Ssm	36	248	14.5%	cbioportal
22	FAT3	Ssm	36	248	14.5%	cbioportal
25	DNAH5	Ssm	35	248	14.1%	cbioportal
24	CHD4	Ssm	35	248	14.1%	cbioportal
27	USH2A	Ssm	35	248	14.1%	cbioportal
26	TAF1	Ssm	35	248	14.1%	cbioportal
28	RYR3	Ssm	34	248	13.7%	cbioportal
29	ANK3	Ssm	33	248	13.3%	cbioportal
30	DNAH10	Ssm	33	248	13.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Uterine Corpus Endometrial Carcinoma (TCGA, Nature 2013) ucec_tcga_pubTCGA

248 cases with simple somatic mutation data · 373 cases total · 2026-01-16 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	161	248	64.9%	cbioportal
2	PIK3CA	Ssm	132	248	53.2%	cbioportal
3	ARID1A	Ssm	83	248	33.5%	cbioportal
4	PIK3R1	Ssm	81	248	32.7%	cbioportal
5	TTN	Ssm	79	248	31.9%	cbioportal
6	CTNNB1	Ssm	74	248	29.8%	cbioportal
7	TP53	Ssm	69	248	27.8%	cbioportal
8	KRAS	Ssm	52	248	21%	cbioportal
9	MUC16	Ssm	48	248	19.4%	cbioportal
10	CSMD3	Ssm	47	248	19%	cbioportal
11	CTCF	Ssm	45	248	18.1%	cbioportal
12	ZFHX3	Ssm	44	248	17.7%	cbioportal
13	MUC5B	Ssm	43	248	17.3%	cbioportal
14	RYR2	Ssm	41	248	16.5%	cbioportal
15	FAT1	Ssm	40	248	16.1%	cbioportal
16	FAT4	Ssm	40	248	16.1%	cbioportal
17	OBSCN	Ssm	39	248	15.7%	cbioportal
19	FBXW7	Ssm	38	248	15.3%	cbioportal
18	DMD	Ssm	38	248	15.3%	cbioportal
20	NEB	Ssm	37	248	14.9%	cbioportal
21	ARHGAP35	Ssm	36	248	14.5%	cbioportal
22	FAT3	Ssm	36	248	14.5%	cbioportal
23	ZFHX4	Ssm	36	248	14.5%	cbioportal
24	CHD4	Ssm	35	248	14.1%	cbioportal
25	DNAH5	Ssm	35	248	14.1%	cbioportal
26	TAF1	Ssm	35	248	14.1%	cbioportal
27	USH2A	Ssm	35	248	14.1%	cbioportal
28	RYR3	Ssm	34	248	13.7%	cbioportal
30	DNAH10	Ssm	33	248	13.3%	cbioportal
29	ANK3	Ssm	33	248	13.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Uterine Corpus Endometrial Carcinoma (TCGA, PanCancer Atlas) ucec_tcga_pan_can_atlas_2018TCGA

517 cases with simple somatic mutation data · 529 cases total · 2026-06-04 · mapped to Endometrial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	337	517	65.2%	cbioportal
2	PIK3CA	Ssm	259	517	50.1%	cbioportal
3	ARID1A	Ssm	227	517	43.9%	cbioportal
4	TTN	Ssm	206	517	39.8%	cbioportal
5	TP53	Ssm	193	517	37.3%	cbioportal
6	PIK3R1	Ssm	159	517	30.8%	cbioportal
7	KMT2D	Ssm	143	517	27.7%	cbioportal
8	MUC16	Ssm	142	517	27.5%	cbioportal
9	CTNNB1	Ssm	133	517	25.7%	cbioportal
10	CTCF	Ssm	127	517	24.6%	cbioportal
11	RYR2	Ssm	125	517	24.2%	cbioportal
12	ZFHX3	Ssm	123	517	23.8%	cbioportal
13	CSMD3	Ssm	122	517	23.6%	cbioportal
14	MUC5B	Ssm	117	517	22.6%	cbioportal
15	OBSCN	Ssm	117	517	22.6%	cbioportal
16	SYNE1	Ssm	114	517	22.1%	cbioportal
17	CHD4	Ssm	113	517	21.9%	cbioportal
18	KMT2B	Ssm	113	517	21.9%	cbioportal
19	FLG	Ssm	112	517	21.7%	cbioportal
20	MACF1	Ssm	109	517	21.1%	cbioportal
21	ZFHX4	Ssm	109	517	21.1%	cbioportal
22	FAT4	Ssm	108	517	20.9%	cbioportal
23	NEB	Ssm	106	517	20.5%	cbioportal
24	USH2A	Ssm	105	517	20.3%	cbioportal
25	TAF1	Ssm	104	517	20.1%	cbioportal
26	ARHGAP35	Ssm	103	517	19.9%	cbioportal
27	DMD	Ssm	103	517	19.9%	cbioportal
28	DNAH7	Ssm	103	517	19.9%	cbioportal
29	FAT1	Ssm	103	517	19.9%	cbioportal
30	PCLO	Ssm	102	517	19.7%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Uterine Endometrioid Carcinoma (CPTAC GDC, 2025) uec_cptac_gdcCPTAC GDC

247 cases with simple somatic mutation data · 442 cases total · 2026-01-14 · mapped to Endometrial Endometrioid Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PTEN	Ssm	194	247	78.5%	cbioportal
2	ARID1A	Ssm	136	247	55.1%	cbioportal
3	PIK3CA	Ssm	105	247	42.5%	cbioportal
4	PIK3R1	Ssm	91	247	36.8%	cbioportal
5	TTN	Ssm	89	247	36%	cbioportal
6	CTNNB1	Ssm	71	247	28.7%	cbioportal
7	KRAS	Ssm	67	247	27.1%	cbioportal
8	OBSCN	Ssm	65	247	26.3%	cbioportal
9	KMT2B	Ssm	62	247	25.1%	cbioportal
10	INPPL1	Ssm	61	247	24.7%	cbioportal
11	KMT2D	Ssm	61	247	24.7%	cbioportal
12	TP53	Ssm	61	247	24.7%	cbioportal
13	CTCF	Ssm	56	247	22.7%	cbioportal
14	SYNE1	Ssm	54	247	21.9%	cbioportal
15	ZFHX3	Ssm	54	247	21.9%	cbioportal
16	PCLO	Ssm	51	247	20.6%	cbioportal
17	MUC16	Ssm	49	247	19.8%	cbioportal
18	MUC5B	Ssm	48	247	19.4%	cbioportal
19	FSIP2	Ssm	47	247	19%	cbioportal
20	CSMD3	Ssm	46	247	18.6%	cbioportal
21	RYR1	Ssm	45	247	18.2%	cbioportal
22	ZFHX4	Ssm	45	247	18.2%	cbioportal
23	JAK1	Ssm	43	247	17.4%	cbioportal
24	RYR2	Ssm	43	247	17.4%	cbioportal
25	DNAH5	Ssm	42	247	17%	cbioportal
26	CHD4	Ssm	41	247	16.6%	cbioportal
27	FAT3	Ssm	41	247	16.6%	cbioportal
28	HERC2	Ssm	41	247	16.6%	cbioportal
29	DNAH17	Ssm	40	247	16.2%	cbioportal
30	FBXW7	Ssm	40	247	16.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-14