RUNX1T1 — gene · CancerIndex

Curated evidence

Clinical evidence (6)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–6 of 6 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RUNX1T1 Fusion6
(prognostic)	Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	A	Supports Better Outcome	5	submitted	EID8558 In the current update of The WHO classification for myeloid malignancies, AML with t(8;21)(q22;q22.1); RUNX1-RUNX1T1, defines a distinct subgroup of AML with recurrent genetic abnormalities. RUNX1-RUN… (full text at CIViC) PMID 27895058 · Döhner et al., 2017 · Open in CIViC	civic
〃	Acute Myeloid Leukemia with t(8;21)(q22;q22.1); RUNX1-RUNX1T1ALIAS	Prognostic	A	Supports Better Outcome	5	accepted	EID11881 This study evaluated the independent prognostic significance of pretreatment cytogenetics based on the large Medical Research Council (MRC) AML 10 trial which enrolled a total of 1,966 patients (364 c…

Cohorts

Alteration frequency by cohort (27)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved27 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cutaneous Squamous Cell Carcinoma (DFCI, Clin Cancer Res 2015) cscc_dfarber_2015	Skin Squamous Cell Carcinoma	Ssm	6

Literature

Linked publications (4)

25 per page, newest first.

pubmedPublishedShowing 1–4 of 4 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The importance of diagnostic cytogenetics on outcome in AML: analysis of 1,612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties.
· Blood · 1998 · PMID 9746770 · validated civic_curation pubmed
Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1/ETO, with similarity to Drosophila segmentation gene, runt.
· Blood · 1992 · PMID 1391946 · validated civic_curation pubmed
Distinctive immunophenotypic features of t(8;21)(q22;q22) acute myeloblastic leukemia in children.
· Blood · 1992 · PMID 1467524 · validated civic_curation pubmed
Morphological subtyping of acute myeloid leukemia with maturation (AML-M2): homogeneous pink-colored cytoplasm of mature neutrophils is most characteristic of AML-M2 with t(8;21).