Gene

PIK3CB

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta

Explore in graph →CI-GENE-00019749HGNC:8976 ENSG00000051382 NCBI 5291 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ATM Mutation + CSF2RB Mutation + NTRK1 Mutation + PIK3CB Mutation + PIK3R1 Mutation + TP53 MutationATM TP53 PIK3R1 PIK3CB NTRK1 CSF2RB1
Doxorubicin	Sarcoma	Predictive	D	Supports Sensitivity Response	3	submitted	EID12721 In primary soft tissue sarcoma cultures (UPS n = 25, SS n = 12), tumors with at least one mutation in apoptosis pathway genes (TP53, ATM, PIK3CB, PIK3R1, NTRK1 or CSF2RB; Mut+ n = 10, Mut− n = 27) wer… (full text at CIViC) PMID 35406568 · Kirilin et al., 2022 · Open in CIViC	civic
PIK3CB E1051K1
(functional)	—UNRESOLVED

Cohorts

Alteration frequency by cohort (85)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved85 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Juvenile Papillomatosis and Breast Cancer (MSK,J Pathol. 2015) brca_jup_msk_2020	Invasive Breast Carcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.