Gene
USP8
ubiquitin specific peptidase 8
Explore in graph →CI-GENE-00038120HGNC:12631 ENSG00000138592 NCBI 9101 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (14)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 36355783
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022 | Colorectal Adenocarcinoma | Ssm | 13 | 19 | 68.4% | 7 | cbioportal |
| Urothelial Cancer Patient Derived Organoids (MSK, 2025) blca_pdx_msk_2025 | Bladder Urothelial Carcinoma | Ssm | 12 | 34 | 35.3% | 24 | cbioportal |
| Acral Melanoma (TGEN, Genome Res 2017) mel_tsam_liang_2017 | Melanoma | Ssm | 8 | 38 | 21.1% | 6 | cbioportal |
| Non-Small Cell Lung Cancer (MSK, 2026) alk_msk_2026 | Lung Non-Small Cell Carcinoma | Ssm | 9 | 46 | 19.6% | 5 | cbioportal |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.