Gene

EIF1AX

eukaryotic translation initiation factor 1A X-linked

Explore in graph →CI-GENE-00044417HGNC:3250 ENSG00000173674 NCBI 1964 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
EIF1AX MUTATION1
(prognostic)	Uveal Melanoma	Prognostic	C	Supports Better Outcome	4	accepted	EID1712 EIF1AX was identified as a uveal melanoma (UM) driver gene by whole-exome sequencing. Approximately 14%–20% of UM carry a mutation in EIF1AX, with most mutations found in exons 1 and 2. EIF1AX mutatio… (full text at CIViC) PMID 23793026 · Martin et al., 2013 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (35)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved35 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Uveal Melanoma (QIMR, Oncotarget 2016) um_qimr_2016	Uveal Melanoma	Ssm	4	26	15.4%

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Exome sequencing identifies recurrent somatic mutations in EIF1AX and SF3B1 in uveal melanoma with disomy 3.
· Nat Genet · 2013 · PMID 23793026 · validated civic_curation pubmed