PTPN6

protein tyrosine phosphatase non-receptor type 6

Explore in graph →CI-GENE-00022504HGNC:9658 ENSG00000111679 NCBI 5777 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PTPN6 Underexpression1
(prognostic)	Hepatocellular Carcinoma	Prognostic	D	Supports Poor Outcome	4	submitted	EID6390 SHP-1 has been shown to be a tumor suppressor in hematopoietic cancers. Reduced SHP-1 expression in HCC correlates to aggressive tumor behavior resulting in a poor prognosis for patients. PMID 29776962 · Wen et al., 2018 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (6)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved6 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Prostate Adenocarcinoma (MSK, Cancer Cell 2010) prad_mskcc	Prostate Adenocarcinoma	Ssm	1	9

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.