RRAS2

RAS related 2

Explore in graph →CI-GENE-00029525HGNC:17271 ENSG00000133818 NCBI 22800 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
RRAS2 Q72L1
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	2	submitted	EID9528 Functional effects of the RRAS2 (TC21) Q72L mutation was assessed in NIH3T3 and 293T cells. RRAS2 Q72L expressed in NIH3T3 cells caused strong activation of AKT by Western blot, higher even than the a… (full text at CIViC) PMID 11850823 · Rong et al., 2002 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (11)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved11 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Germ Cell Tumors and Shared Leukemias (MSK, J Clin Invest 2020) gct_msk_2020	unmapped	Ssm	4	13	30.8%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.