BLK

BLK proto-oncogene, Src family tyrosine kinase

Explore in graph →CI-GENE-00021841HGNC:1057 ENSG00000136573 NCBI 640 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
BLK Expression1
Ibrutinib	B Acute Lymphoblastic LeukemiaALIAS	Predictive	D	Supports Sensitivity Response	3	submitted	EID9288 A preclinical study investigated BTK inhibitor ibrutinib as a potential inhibitor for patients with pre-BCR + B cell acute lymphoblastic leukemia (B-ALL). In validating the significance of BTK and BLK… (full text at CIViC) PMID 28031181 · Kim et al., 2017 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (4)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved4 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Melanoma (Broad/Dana Farber, Nature 2012) skcm_broad_dfarber	Cutaneous Melanoma	Ssm	4	26

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.