MAML2 — gene · CancerIndex

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MAML2 Fusion3
(diagnostic)	Salivary Gland Mucoepidermoid Carcinoma	Diagnostic	B	Supports Positive	4	accepted	EID11591 In this 2010 study, the authors included 55 salivary gland mucoepidermoid carcinomas (MEC) and a control group of 36 potential MEC mimics, including Warthin tumors, oncocytomas, squamous cell carcinom… (full text at CIViC) PMID 20588178 · Seethala et al., 2010 · Open in CIViC	civic
〃	Salivary Gland Mucoepidermoid Carcinoma	Diagnostic	B	Supports Positive	3	accepted	EID11592 In this 2013 study, the authors investigated 95 salivary gland mucoepidermoid carcinomas (MEC) using FFPE material. RT-PCR and FISH were utilized to detect CRTC1::MAML2 and CRTC3::MAML2 fusions, as we… (full text at CIViC) PMID 23035786 · Noda et al., 2013 · Open in CIViC

Cohorts

Alteration frequency by cohort (4)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved4 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Squamous Cell Carcinoma of the Vulva (CUK, Exp Mol Med 2018) vsc_cuk_2018	Vaginal Squamous Cell Carcinoma, Not Otherwise Specified	Ssm

Literature

Linked publications (4)

25 per page, newest first.

pubmedPublishedShowing 1–4 of 4 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

A reappraisal of the MECT1/MAML2 translocation in salivary mucoepidermoid carcinomas.
· Am J Surg Pathol · 2010 · PMID 20588178 · validated civic_curation pubmed
Clinicopathological significance of MAML2 gene split in mucoepidermoid carcinoma.
· Cancer Sci · 2013 · PMID 23035786 · validated civic_curation pubmed
Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma.
· Mod Pathol · 2009 · PMID 19749740 · validated civic_curation pubmed
Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions.
· Acta Neuropathol Commun · 2021 · PMID 34389065 · validated civic_curation