Gene
AFF1
ALF transcription elongation factor 1
Explore in graph →CI-GENE-00000634HGNC:7135 ENSG00000172493 NCBI 4299 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (16)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 22561520
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Cholangiocarcinoma (National University of Singapore, Nat Genet 2012) chol_nus_2012 | Cholangiocarcinoma | Ssm | 1 | 8 | 12.5% | 15 | cbioportal |
| Upper Tract Urothelial Carcinoma (Cornell/Baylor/MDACC, Nat Commun 2019) utuc_cornell_baylor_mdacc_2019 | Renal Pelvis and Ureter Urothelial Carcinoma | Ssm | 4 | 37 | 10.8% | 10 | cbioportal |
| Cutaneous Squamous Cell Carcinoma (DFCI, Clin Cancer Res 2015) cscc_dfarber_2015 | Skin Squamous Cell Carcinoma | Ssm | 3 | 29 | 10.3% | 139 | cbioportal |
| Bladder Urothelial Carcinoma (DFCI/MSK, Cancer Discov 2014) blca_dfarber_mskcc_2014 | Bladder Urothelial Carcinoma | Ssm | 4 | 50 | 8% |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.