Gene
SESN1
sestrin 1
Explore in graph →CI-GENE-00030386HGNC:21595 ENSG00000080546 NCBI 27244 Approved
Curated evidence
Clinical evidence (0)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
Data not yet available
No curated evidence item involves this gene yet.
Cohorts
Alteration frequency by cohort (6)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
cbioportalProvenance
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 36355783
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022 | Colorectal Adenocarcinoma | Ssm | 8 | 22 | 36.4% | 137 | cbioportal |
| Urothelial Cancer Patient Derived Organoids (MSK, 2025) blca_pdx_msk_2025 | Bladder Urothelial Carcinoma | Ssm | 4 | 46 | 8.7% | 169 | cbioportal |
| High-Grade Serous Ovarian Cancer (MSK, NPJ Genome Med 2021) hgsoc_msk_2021 | High-Grade Serous Ovarian Cancer | Ssm | 1 | 28 | 3.6% | 93 | cbioportal |
| Pancreatic Acinar Cell Carcinoma (MSK, JCO 2023) paac_msk_jco_2023 | Pancreatic Acinar Cell Carcinoma | Ssm | 1 | 33 | 3% | 153 |
Literature
Linked publications (0)
Data not yet available
No publication linked to this gene yet.