SUFU

SUFU negative regulator of hedgehog signaling

Explore in graph →CI-GENE-00034197HGNC:16466 ENSG00000107882 NCBI 51684 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
SUFU Deletion1
Sonidegib	MedulloblastomaCURATED_BROADER	Predictive	D	Supports Resistance	3	submitted	EID5324 In a sonic hedgehog driven medulloblastoma patient derived xenograft harbouring a SUFU deletion, SMO inhibition with LDE225 (Sonidegib) did not affect cell proliferation. PMID 24651015 · Kool et al., 2014 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (30)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved30 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, JCO Precis Oncol 2022) crc_dd_2022	Colorectal Adenocarcinoma	Ssm	5	47

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.