Gene

PIK3R2

phosphoinositide-3-kinase regulatory subunit 2

Explore in graph →CI-GENE-00019758HGNC:8980 ENSG00000105647 NCBI 5296 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
BRAF V600E + PIK3R2 N561DBRAF PIK3R21
Vemurafenib	Melanoma	Predictive	D	Supports Resistance	3	accepted	EID4783 An in vitro study of WM2664 (a human melanoma cell line) endogenously expressing wildtype PIK3R2 and BRAF V600D (a known BRAF inhibitor sensitizing mutation) found that cells virally induced to stably… (full text at CIViC) PMID 24265155 · Shi et al., 2014 · Open in CIViC	civic
PIK3R2 G373R1
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	1	accepted	EID9420 Lymphoblastoid cell lines were derived from patients with megalencephaly syndromes, who had the PIK3R2 p.G373R mutation. PIP3 immunostaining was used to compared PI3K activity among mutant and control…

Cohorts

Alteration frequency by cohort (85)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved85 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Endometrial and Ovarian Cancer (MSK, Nature Medicine 2024) ucec_msk_2024	unmapped	Ssm	6	33

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy.
· Cancer Discov · 2014 · PMID 24265155 · validated civic_curation pubmed
De novo germline and postzygotic mutations in AKT3, PIK3R2 and PIK3CA cause a spectrum of related megalencephaly syndromes.
· Nat Genet · 2012 · PMID 22729224 · validated civic_curation pubmed