Gene

AFDN

afadin, adherens junction formation factor

Explore in graph →CI-GENE-00000632HGNC:7137 ENSG00000130396 NCBI 4301 Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
AFDN Fusion2
(prognostic)	Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	5	submitted	EID9748 In this study of pediatric cases of acute myeloid leukemia (AML) comparing the prognosis of several recurrent translocation partners for the KMT2A/MLL gene at 11q23, the specific MLL-AF6 fusion gene (… (full text at CIViC) PMID 19528532 · Balgobind et al., 2009 · Open in CIViC	civic
〃	Childhood Acute Myeloid LeukemiaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	4	submitted	EID8515 This is a large international retrospective study of the association between fusion partner and outcome in 756 children with KMT2A-rearranged (also known as MLL-rearranged) AML from 11 study group inc… (full text at CIViC)

Cohorts

Alteration frequency by cohort (45)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved45 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
NCI-60 Cell Lines (NCI, Cancer Res 2012) cellline_nci60	unmapped	Ssm	18	60	30%

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.