Gene
STAT1
signal transducer and activator of transcription 1
Explore in graph →CI-GENE-00034017HGNC:11362 ENSG00000115415 NCBI 6772 CIViC Approved
Curated evidence
Clinical evidence (2)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 15668815
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| STAT1 Expression1 | ||||||||
| (prognostic) | Melanoma | Prognostic | B | Does Not Support N/A | 3 | submitted | EID10316A cohort of 28 patients with malignant melanoma, with previously excised high-risk lesions were evaluated for STAT1 and STAT2 expression prior to treatment with v. interferon-alpha 2b (IFN-a2b). Stain… (full text at CIViC) PMID 15668815 · Lesinski et al., 2005 · Open in CIViC | civic |
| STAT1 Overexpression1 | ||||||||
| Cisplatin + PicoplatinSubstitutes | Malignant Ovarian Neoplasm | Predictive | D | Supports Resistance | 3 | submitted | EID7951Researchers calculated Spearman rank correlation coefficients for each gene vs proliferation rate and platinum drug sensitivity in 14 ovarian cancer cell lines. STAT1 expression was found to be highly… | |
Cohorts
Alteration frequency by cohort (2)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 20579941
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Prostate Adenocarcinoma (MSK, Cancer Cell 2010) prad_mskcc | Prostate Adenocarcinoma | Ssm | 1 | 9 |
Literature
Linked publications (0)
Data not yet available