Gene

PTPRF

protein tyrosine phosphatase receptor type F

Explore in graph →CI-GENE-00022535HGNC:9670 ENSG00000142949 NCBI 5792 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PTPRF EXPRESSION2
(prognostic)	Lung Non-Small Cell CarcinomaCURATED_BROADER	Prognostic	B	Supports Poor Outcome	3	submitted	EID2910 PTPRF expression was found to be prognostic for shorter overall survival but was also significantly predictive of improved survival with erlotinib versus placebo in SATURN even in the EGFR wild-type … (full text at CIViC) PMID 26291013 · Soulières et al., 2015 · Open in CIViC	civic
Erlotinib Hydrochloride	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	submitted	EID2909 PTPRF expression was found to be prognostic for shorter overall survival but was also significantly predictive of improved survival with erlotinib versus placebo in SATURN even in the EGFR wild-type s…

Cohorts

Alteration frequency by cohort (13)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved13 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Renal Cell Carcinoma (IMmotion150 Clinical Trial, Nat Med. 2018) - iAtlas Harmonized rcc_iatlas_immotion150_2018	Renal Cell Carcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.