Gene

LPP

LIM domain containing preferred translocation partner in lipoma

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
LPP Fusion1
(diagnostic)	Liposarcoma	Diagnostic	B	Supports Negative	4	rejected	EID7984 Both RT-PCR and PCR were used to detect and confirm the presence of fusion transcripts in RNA extracted from the surgical resections of 74 liposarcomas and 98 lipomas. HMGA2-LPP was found in 19/98 (19… (full text at CIViC) PMID 20332486 · Kubo et al., 2010 · Open in CIViC	civic
LPP Fusion + HMGA2 FusionHMGA2 LPP1
(diagnostic)	Liposarcoma	Diagnostic	B	Supports Negative	4	accepted	EID7983 Both RT-PCR and PCR were used to detect and confirm the presence of fusion transcripts in RNA extracted from the surgical resections of 74 liposarcomas and 98 lipomas. LPP-HMGA2 or HMGA2-LPP fusions w…

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved6 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma TCGA-CESC	Cervical CarcinomaCURATED_BROADER

Literature

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Specificity of fusion genes in adipocytic tumors.
· Anticancer Res · 2010 · PMID 20332486 · validated civic_curation pubmed