Gene

STAT5B

signal transducer and activator of transcription 5B

Explore in graph →CI-GENE-00034023HGNC:11367 ENSG00000173757 NCBI 6777 CIViC Approved

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
STAT5B Overexpression1
Multi-subtype Natural Human Leukocyte Interferon Alpha	Melanoma	Predictive	A	Supports Resistance	3	submitted	EID9777 The examination of interferon-resistant melanoma cell lines in relation to STAT5 expression, indicated a correlation between overexpression and resistance to interferon α (IFNα) immunotherapy. From an… (full text at CIViC) PMID 16169484 · Wellbrock et al., 2005 · Open in CIViC	civic
STAT5B Y665F1
(prognostic)	Prolymphocytic Leukemia	Prognostic	B	Supports Poor Outcome	2	submitted	EID8029 Meta-analysis of 275 T-cell prolymphocytic leukemia (T-PLL) patients from 10 different studies. Sequencing data from each study (Sanger sequencing, targeted amplicon sequencing, whole exome sequencing…

Cohorts

Alteration frequency by cohort (28)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved28 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	7

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.