Gene

BRD4

bromodomain containing 4

Explore in graph →CI-GENE-00022052HGNC:13575 ENSG00000141867 NCBI 23476 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
BRD4 Overexpression3
Unspecified therapy	Melanoma	Predictive	D	Supports Sensitivity Response	3	submitted	EID9315 BET inhibitor JQ-1 induced a decrease in viability to NRAS mutant melanoma cells with an increase in sensitivity in those highly expressing BRD4 in comparison to BRD2 and BRD3 expression (P = 0.018); … (full text at CIViC) PMID 29650805 · Echevarría-Vargas et al., 2018 · Open in CIViC	civic
JQ1	Clear Cell Renal Cell Carcinoma	Predictive	D	Supports Sensitivity Response	2	submitted	EID2957 Renal cell carcinoma (RCC) remains an intractable genitourinary malignancy. Resistance to chemotherapy or targeted therapies in RCC is presumably due to the complicated underlying molecular mechanisms… (full text at CIViC) PMID 28391274 · Wu et al., 2017 · Open in CIViC

Cohorts

Alteration frequency by cohort (137)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved137 cohort rows (showing 50, sorted by frequency) · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.