Gene

MTAP

methylthioadenosine phosphorylase

Explore in graph →CI-GENE-00015282HGNC:7413 ENSG00000099810 NCBI 4507 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MTAP Deletion2
Anvumetostat	Solid NeoplasmCURATED_BROADER	Predictive	B	Supports Sensitivity Response	3	accepted

Cohorts

Alteration frequency by cohort (9)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved9 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Skin Cutaneous Melanoma TCGA-SKCM	Cutaneous Melanoma	Ssm

Literature

Linked publications (2)

25 per page, newest first.

pubmedPublishedShowing 1–2 of 2 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

First-in-human study of AMG 193, an MTA-cooperative PRMT5 inhibitor, in patients with MTAP-deleted solid tumors: results from phase 1 dose exploration.
· Ann Oncol · 2024 · PMID 39293516 · validated civic_curation pubmed
Characterization of MTAP Gene Expression in Breast Cancer Patients and Cell Lines.
· PLoS One · 2016 · PMID 26751376 · validated civic_curation pubmed

MTAP Underexpression1
Pyrimidine Antagonist	Malignant Breast Neoplasm	Predictive	D	Supports Sensitivity Response	1	accepted	EID1980 MTAP and CDKN2A gene (RT-qPCR) and protein (western-blotting) expression as well as promoter methylation status were analyzed in breast cancer patients and seven breast cancer cell lines. Knockdown of… (full text at CIViC) PMID 26751376 · de Oliveira et al., 2016 · Open in CIViC	civic

MTAP Underexpression1

Pyrimidine Antagonist

Malignant Breast Neoplasm

Predictive

Supports Sensitivity Response

accepted

EID1980

MTAP and CDKN2A gene (RT-qPCR) and protein (western-blotting) expression as well as promoter methylation status were analyzed in breast cancer patients and seven breast cancer cell lines. Knockdown of… (full text at CIViC)

PMID 26751376 · de Oliveira et al., 2016 · Open in CIViC

civic

CDKN2A Underexpression + MTAP UnderexpressionMTAP CDKN2A1
Pemetrexed	Lung Adenocarcinoma	Predictive	B	Supports Sensitivity Response	2	submitted	EID12723 In a retrospective cohort of metastatic lung adenocarcinoma from the BATTLE-2 trial (n = 72), patients with CDKN2A and MTAP co-underexpression tumors (n = 26; representative for 9p21 loss) demonstrate… (full text at CIViC) PMID 35379845 · Alhalabi et al., 2022 · Open in CIViC	civic

CDKN2A Underexpression + MTAP UnderexpressionMTAP CDKN2A1

Pemetrexed

Lung Adenocarcinoma

Predictive

Supports Sensitivity Response

submitted

EID12723

In a retrospective cohort of metastatic lung adenocarcinoma from the BATTLE-2 trial (n = 72), patients with CDKN2A and MTAP co-underexpression tumors (n = 26; representative for 9p21 loss) demonstrate… (full text at CIViC)

PMID 35379845 · Alhalabi et al., 2022 · Open in CIViC

civic